Diffusion MRI

1st Edition

From quantitative measurement to in-vivo neuroanatomy

Print ISBN: 9780123747099
eBook ISBN: 9780080878515
Imprint: Academic Press
Published Date: 20th April 2009
Page Count: 502
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Diffusion MRI is a magnetic resonance imaging (MRI) method that produces in vivo images of biological tissues weighted with the local microstructural characteristics of water diffusion, providing an effective means of visualizing functional connectivities in the nervous system. This book is the first comprehensive reference promoting the understanding of this rapidly evolving and powerful technology and providing the essential handbook for designing, analyzing or interpreting diffusion MR experiments. The book presents diffusion imaging in the context of well-established, classical experimental techniques, so that readers will be able to assess the scope and limitations of the new imaging technology with respect to techniques available previously. All chapters are written by leading international experts and cover methodology, validation of the imaging technology, application of diffusion imaging to the study of variation and development of normal brain anatomy, and disruption to the white matter in neurological disease or psychiatric disorder.

Key Features

• Discusses all aspects of a diffusion MRI study from acquisition, through analysis, to interpretation, providing an essential reference text for scientists designing or interpreting diffusion MR experiments • Practical advice on running an experiment • Full color throughout


Neuroscientists interested in the study of connections in the brain, brain imaging, within Cognitive Neuroscience, Neuroscience, Radiology, Medical Physics and adjacent areas.

Table of Contents

Section 1: Introduction to diffusion MRI 1 Introduction to Diffusion MR - Peter J. Basser and Evren Özarslan 2 Pulse sequences for diffusion-weighted MRI - James Pipe 3 Gaussian modelling of the diffusion signal - Derek K Jones 4 Multiple fibres: beyond the diffusion tensor - Kiran K Seunarine and Daniel C Alexander Section 2: Diffusion MRI for quantitative measurement 5 White matter structure: a microscopist’s view - Julia M. Edgar and Ian R. Griffiths 6 The biological basis of diffusion anisotropy - Christian Beaulieu 7 Inferring microstructural information of white matter from diffusion MRI - Yaniv Assaf and Yoram Cohen 8 Cross-Subject Comparison of Local Diffusion MRI Parameters - Steven Smith and Gordon Kindlmann 9 Diffusion MRI in neurological disorders - Benedetta Bodini and Olga Ciccarelli 10 DTI in development and aging - David Salat, Stephanie Y. Lee, Bindu Setty, H. Diana Rosas and P. Ellen Grant 11 Individual differences in white matter microstructure in the healthy brain - Jan Scholz, Heidi Johansen-Berg and Valentina Tomassini 12 Diffusion tensor imaging and its application to schizophrenia and related disorders - Martha Shenton Section 3: Diffusion MRI for in-vivo neuroanatomy 13 Classic and contemporary neural tract tracing techniques - Robert J. Morecraft, Gabriella Ugolini, José L. Lanciego, Floris G. Wouterlood and Deepak N. Pandya 14 The human connectome: linking structure and function in the human brain - Olaf Sporns 15 MR diffusion tractography - Timothy E.J. Behrens and Saad Jbabdi 16 Validation of tractography - Penny L. Hubbard and Geoffrey J. M. Parker 17 Connectivity fingerprinting of grey matter - Johannes C Klein, Timothy E.J. Behrens and Heidi Johansen-Berg 18 The connectional anat


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"A thorough and exciting review of the diffusion MRI techniques that are going to rewrite our knowledge of the long tract anatomy of the human brain. Extremely well written and illustrated." - Michael S. Gazzaniga, Director, Sage Center for the Study of Mind, University of California, Santa Barbara, USA

"25 years after its debut, diffusion MRI today provides us with beautiful, marvelous images of connecting wires within the human brain, and this is achieved just by placing healthy subjects or patients in the middle of a strong magnet. How is this miracle possible? What could we expect from the knowledge of the brain connectome? This beautifully illustrated book addresses these questions with great clarity. The book is highly recommendable to all those who are interested in the links between brain structure and function." - Denis Le Bihan, Member of the Institut de France, Academy of Sciences; Director, NeuroSpin; CEA-Saclay Center, Gif-sur-Yvette, France

"Unbelievable as it may seem, we know almost nothing about the real connectivity of the human cerebral cortex. What we think we know is mostly inferred from results obtained in the monkey. This book provides an exciting exploration of diffusion tensor imaging, a method that can start to close this gap. The editors, who are themselves pioneers in this field, have assembled authoritative chapters on the promises that lie ahead and the challenges that will be encountered." - Marsel Mesulam, Ruth and Evelyn Dunbar Professor of Neurology, Psychiatry and Psychology; Director, The Cognitive Neurology and Alzheimer's Disease Center (CNADC), Feinberg School of Medicine, Northwestern University, Chicago, USA

"Diffusion MRI has tremendous potential for elucidating brain structure and circuitry in health and disease, but the approach is fraught with methodological and interpretational challenges. This excellent and authoritative book edited by Johansen-Berg and Beh