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Dietary Supplements - 1st Edition - ISBN: 9781782420767, 9781782420811

Dietary Supplements

1st Edition

Safety, Efficacy and Quality

Editors: Katja Berginc Samo Kreft
Hardcover ISBN: 9781782420767
eBook ISBN: 9781782420811
Imprint: Woodhead Publishing
Published Date: 7th November 2014
Page Count: 260
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Table of Contents

    <li>List of contributors</li> <li>Woodhead Publishing Series in Food Science, Technology and Nutrition</li> <li>Introduction</li> <li>Part One: General issues<ul><li>1: Dietary supplement labelling and health claims<ul><li>Abstract</li><li>1.1 Introduction: the regulatory situation in the European Union (EU)</li><li>1.2 Labelling requirements</li><li>1.3 Nutrition claims</li><li>1.4 Health claims</li><li>1.5 Borderline substances: between foods and medicine</li><li>1.6 Conclusions</li><li>Acknowledgements</li><li>Appendix: abbreviations</li></ul></li><li>2: Good manufacturing practice (GMP) in the production of dietary supplements<ul><li>Abstract</li><li>2.1 Introduction</li><li>2.2 Key issues related to good manufacturing practice/good hygienic practice (GMP/GHP) implementation</li><li>2.3 Documentation of GMP</li><li>2.4 Benefits and drawbacks of GMP use in organisations</li><li>2.5 Summary</li></ul></li><li>3: Analysing the composition of fortified foods and supplements: the case of vitamins<ul><li>Abstract</li><li>3.1 Introduction</li><li>3.2 Extraction and purification methods</li><li>3.3 High performance liquid chromatography (HPLC)</li><li>3.4 Gas chromatography (GC)</li><li>3.5 Capillary electrophoresis (CE)</li><li>3.6 Spectroscopic methods</li><li>3.7 Microbiological methods</li><li>3.8 Immunoassays</li><li>3.9 Other methods</li><li>3.10 Future trends</li></ul></li></ul></li> <li>Part Two: Drug&#x2013;supplement interactions<ul><li>4: Pharmacokinetic interactions between drugs and dietary supplements: herbal supplements<ul><li>Abstract</li><li>4.1 Introduction</li><li>4.2 Herbals: introduction</li><li>4.3 <i>Hypericum perforatum</i> (St John's Wort (SJW))</li><li>4.4 <i>Allium sativum</i> (garlic)</li><li>4.5 <i>Ginkgo biloba</i> (ginkgo)</li><li>4.6 <i>Panax ginseng</i> (ginseng), <i>Piper methysticum</i> (kava kava) and <i>Serenoa repens</i> (saw palmetto)</li><li>4.7 <i>Echinacea purpurea</i> (purple coneflower), <i>Vaccinium macrocarpon</i> (cranberry) and <i>Silybum marianum</i> (milk thistle)</li><li>4.8 <i>Hydrastis canadensis</i> (goldenseal), <i>Valeriana officinalis</i> (valerian) and <i>Cimicifuga racemosa</i> (black cohosh)</li><li>4.9 <i>Glycine max</i> (soy), <i>Camellia sinensis</i> (green tea) and <i>Zingiber officinale</i> (ginger)</li><li>4.10 <i>Morinda citrifolia</i> (noni), <i>Aloe vera</i> (aloe), <i>Vitis vinifera</i> (grape seed) and <i>Curcuma longa</i> (turmeric)</li><li>4.11 <i>Stevia rebaudiana</i> (stevia), <i>Lepidium meyenii</i> (maca) and <i>Garcinia mangostana</i> (mangosteen)</li><li>4.12 Summary</li></ul></li><li>5: Pharmacokinetic interactions between drugs and dietary supplements: probiotic and lipid supplements<ul><li>Abstract</li><li>5.1 Introduction</li><li>5.2 Probiotics and drug delivery in the colon</li><li>5.3 Probiotics: summary</li><li>5.4 Lipids and drug delivery</li><li>5.5 Lipidic excipients and drug release</li><li>5.6 Summary: pharmacokinetic drug&#x2013;lipid interactions</li></ul></li><li>6: Pharmacokinetic interactions between drugs and dietary supplements: carbohydrate, protein, vitamin and mineral supplements<ul><li>Abstract</li><li>6.1 Introduction</li><li>6.2 Carbohydrates as dietary supplements</li><li>6.3 Carbohydrates as pharmaceutical excipients and prodrugs</li><li>6.4 Carbohydrates: summary</li><li>6.5 Proteins, peptides, and amino acids</li><li>6.6 The impact of proteins on drug pharmacokinetics and their use as prodrugs</li><li>6.7 Proteins: summary</li><li>6.8 Vitamins</li><li>6.9 Vitamins: summary</li><li>6.10 Minerals and oligoelements</li><li>6.11 Minerals: summary</li></ul></li><li>7: Pharmacodynamic interactions between drugs and dietary supplements<ul><li>Abstract</li><li>7.1 Introduction</li><li>7.2 Vitamins</li><li>7.3 Minerals</li><li>7.4 Herbal supplements</li><li>7.5 Antioxidants</li><li>7.6 Conclusion</li></ul></li></ul></li> <li>Part Three: Vitamins, minerals and probiotics as dietary supplements<ul><li>8: Vitamins/minerals as dietary supplements: a review of clinical studies<ul><li>Abstract</li><li>8.1 Introduction: efficacy in clinical trials does not guarantee practical impact</li><li>8.2 Are some natural metabolites conditionally essential nutrients?</li><li>8.3 Use of supplements to improve micronutrient adequacy</li><li>8.4 Do folic acid supplements prevent neural tube defects (NTDs)?</li><li>8.5 Do supplements of the ACE vitamins and selenium reduce cancer and heart disease mortality?</li><li>8.6 Do vitamin C supplements prevent or ameliorate the common cold?</li><li>8.7 Do vitamin D (and calcium) supplements improve bone health and have wider benefits?</li><li>8.8 Can supplements of essential minerals reduce blood pressure?</li><li>8.9 Should parents in areas without fluoridated water give their children fluoride supplements?</li><li>8.10 Do micronutrients improve immune function in the elderly?</li><li>8.11 Conclusions</li></ul></li><li>9: Reviewing clinical studies of probiotics as dietary supplements: probiotics for gastrointestinal disorders, <i>Helicobacter</i> eradication, lactose malabsorption and inflammatory bowel disease (IBD)<ul><li>Abstract</li><li>9.1 Introduction</li><li>9.2 Probiotics for gastrointestinal disorders</li><li>9.3 Probiotics for <i>Helicobacter</i> eradication</li><li>9.4 Probiotics for lactose malabsorption</li><li>9.5 Probiotics for inflammatory bowel disease (IBD) and associated conditions</li><li>9.6 Safety of probiotics</li><li>9.7 Conclusions and future trends</li></ul></li><li>10: Reviewing clinical studies of probiotics as dietary supplements: probiotics for atopic and allergic disorders, urinary tract and respiratory infections<ul><li>Abstract</li><li>10.1 Introduction</li><li>10.2 Probiotics for atopic and allergic disorders</li><li>10.3 Probiotics for urogenital infections</li><li>10.4 Probiotics for respiratory tract infections</li><li>10.5 Conclusions</li></ul></li><li>11: Reviewing clinical studies of probiotics as dietary supplements: probiotics for oral healthcare, rheumatoid arthritis, cancer prevention, metabolic diseases and postoperative infections<ul><li>Abstract</li><li>11.1 Introduction</li><li>11.2 Probiotics for oral healthcare</li><li>11.3 Probiotics for rheumatoid arthritis</li><li>11.4 Probiotics for cancer prevention</li><li>11.5 Probiotics for metabolic diseases</li><li>11.6 Probiotics for postoperative infections</li><li>11.7 Conclusions</li></ul></li></ul></li> <li>Index</li>


Dietary supplements made from foods, herbs and their constituents are a rapidly growing market sector. Consumers often view food supplements as ‘natural’ and therefore safe; however, supplements are regulated as foods rather than as pharmaceuticals and so are not as closely monitored as may be necessary. With the commercial market in these products growing, this book provides essential research into their safety, efficacy and potential risk of interaction with pharmaceuticals. Following an introductory chapter, part one covers the chemical composition, manufacture and regulation of dietary supplements. Part two looks at the effectiveness of different types of dietary supplement and methods of evaluation. Finally, part three focuses on supplement safety.

Key Features

  • Reviews the design, production and regulation of dietary supplements.
  • Analyses the potential for pharmacokinetic and pharmacodynamics interactions between dietary supplements and pharmaceuticals.
  • Offers reviews of important clinical studies on the efficacy of dietary supplements for range of conditions.


R&D managers in the nutraceutical and dietary supplement sectors, healthcare professionals and academic researchers


No. of pages:
© Woodhead Publishing 2015
7th November 2014
Woodhead Publishing
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Editors

Katja Berginc

Katja Berginc, University of Ljubljana, Slovenia.

Affiliations and Expertise

Faculty of Pharmacy in the University of Ljubljana, Slovenia

Samo Kreft

Samo Kreft, University of Ljubljana, Slovenia.

Affiliations and Expertise

Biotechnical Faculty, University of Ljubljana, Slovenia