Diamond-Based Materials for Biomedical Applications

Diamond-Based Materials for Biomedical Applications

1st Edition - March 19, 2013

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  • Editor: R Narayan
  • eBook ISBN: 9780857093516
  • Hardcover ISBN: 9780857093400

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Description

Carbon is light-weight, strong, conductive and able to mimic natural materials within the body, making it ideal for many uses within biomedicine. Consequently a great deal of research and funding is being put into this interesting material with a view to increasing the variety of medical applications for which it is suitable. Diamond-based materials for biomedical applications presents readers with the fundamental principles and novel applications of this versatile material.Part one provides a clear introduction to diamond based materials for medical applications. Functionalization of diamond particles and surfaces is discussed, followed by biotribology and biological behaviour of nanocrystalline diamond coatings, and blood compatibility of diamond-like carbon coatings. Part two then goes on to review biomedical applications of diamond based materials, beginning with nanostructured diamond coatings for orthopaedic applications. Topics explored include ultrananocrystalline diamond for neural and ophthalmological applications, nanodiamonds for drug delivery systems, and diamond nucleation and seeding techniques for tissue regeneration. Finally, the book concludes with a discussion of diamond materials for microfluidic devices.With its distinguished editors and international team of expert contributors, Diamond-based materials for biomedical applications is an authoritative guide for all materials scientists, researchers, medical practitioners and academics investigating the properties and uses of diamond based materials in the biomedical environment.

Key Features

  • Presents the fundamental principles and novel applications of this versatile material
  • Discusses the functionalization of diamond particles and surfaces, biotribology and biological behaviour of nanocrystalinediamond coatings and blood compatibility of diamond-like carbon coatings
  • Reviews nanostructured diamond coatings for orthopaedic coatings

Readership

Materials scientists and researchers concerned with the properties and uses of carbon

Table of Contents

  • Contributor contact details

    Woodhead Publishing Series in Biomaterials

    Part I: Introduction to diamond-based materials for medical applications

    Chapter 1: Introduction to medical applications of diamond particles and surfaces

    Abstract:

    1.1 Introduction

    1.2 Growth of synthetic diamond

    1.3 Diamond-based medical devices

    1.4 Functionalization of nanodiamond and nanocrystalline diamond

    1.5 Drug delivery using nanodiamond

    1.6 Imaging with nanodiamond

    1.7 Conclusion

    1.8 Acknowledgments

    Chapter 2: Functionalization of diamond surfaces for medical applications

    Abstract:

    2.1 Introduction

    2.2 Electrochemical reduction of aryldiazonium salts

    2.3 Photochemical modification

    2.4 Preparation of amine-terminated diamond surfaces

    2.5 Preparation of oxygen-terminated diamond surfaces

    2.6 Conclusion and future trends

    Chapter 3: Biotribology and biological behaviour of nanocrystalline diamond (NCD) coatings for medical applications

    Abstract:

    3.1 Introduction to nanocrystalline diamond (NCD)

    3.2 NCD-coated silicon nitride ceramics as new materials for joint replacement

    3.3 Growth and characterization of NCD films deposited on Si3N4 substrates

    3.4 Biotribology of NCD coatings

    3.5 Biological behaviour of NCD-coated Si3N4 ceramics

    Chapter 4: Blood compatibility of diamond-like carbon (DLC) coatings

    Abstract:

    4.1 Introduction

    4.2 Diamond-like carbon (DLC) structure, properties and applications

    4.3 Deposition techniques for DLC films

    4.4 DLC blood compatibility

    4.5 Modified DLC films

    4.6 Biomedical applications of DLC coatings

    4.7 Conclusion and future trends

    Part II: Biomedical applications of diamond-based materials

    Chapter 5: Nanostructured diamond coatings for orthopaedic applications

    Abstract:

    5.1 Introduction

    5.2 Ultra-hard carbon coatings

    5.3 Wear measurements for ceramic-based orthopaedic implants

    5.4 Mesenchymal stem cells derived from bone marrow and their interactions with nanostructured diamond surfaces

    5.5 Macrophage cell interactions to diamond wear debris

    5.6 In vivo evaluation of nanostructured diamond surfaces

    5.7 Future trends

    5.8 Acknowledgements

    Chapter 6: Ultrananocrystalline diamond (UNCD) films for ophthalmological applications

    Abstract:

    6.1 Introduction

    6.2 The use of ultrananocrystalline diamond (UNCD) films as coatings in the restoration of sight in people blinded by degenerated photoreceptors

    6.3 The use of UNCD films in the treatment of glaucoma

    6.4 Integrated magnet/superparamagnetic nanoparticles interacting system for new treatment of retina detachment

    6.5 Conclusions

    6.6 Acknowledgments

    Chapter 7: Ultrananocrystalline diamond (UNCD) for neural applications

    Abstract:

    7.1 Introduction

    7.2 Mechanism aspects of ultrananocrystalline diamond (UNCD)/neural cell interactions

    7.3 Methods of guiding neurons

    7.4 Neural and retinal prostheses

    Chapter 8: Nanodiamonds for drug delivery systems

    Abstract:

    8.1 Introduction

    8.2 Surface modification of diamond nanoparticles for drug delivery and targeting

    8.3 Development of nanodiamond-based drug delivery for proteins

    8.4 Development of nanodiamond-based drug delivery for genes

    8.5 Development of nanodiamond-based drug delivery for low molecular weight therapeutic agents

    8.6 Biocompatibility, biodistribution and biological fate of nanodiamonds

    8.7 Conclusions

    Chapter 9: Diamond nucleation and seeding techniques for tissue regeneration

    Abstract:

    9.1 Introduction

    9.2 Diamond nucleation

    9.3 Methods for diamond nucleation and seeding

    9.4 Bias enhanced nucleation in hot filament chemical vapour deposition

    9.5 Ultrasonic seeding

    9.6 Seeding using a polymer composite

    9.7 Spontaneous nucleation

    9.8 Biological and tissue engineering applications

    Chapter 10: Diamond materials for microfluidic devices

    Abstract:

    10.1 Introduction

    10.2 Materials for the manufacture of microfluidic devices

    10.3 Diamond microfluidic devices

    10.4 Conclusions and future trends

    10.5 Acknowledgments

    Index

Product details

  • No. of pages: 296
  • Language: English
  • Copyright: © Woodhead Publishing 2013
  • Published: March 19, 2013
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780857093516
  • Hardcover ISBN: 9780857093400

About the Editor

R Narayan

Dr. Roger Narayan is a Professor in the Joint Department of Biomedical Engineering at the University of North Carolina and North Carolina State University. He is an author of over two hundred publications as well as several book chapters on processing of biomedical materials. He currently serves as an editorial board member for several academic journals, including as editor-in-chief of Medical Devices & Sensors (Wiley) and associate editor of Applied Physics Reviews (AIP Publishing). Dr. Narayan has also edited several books, including the textbook Biomedical Materials (Springer), the handbook Materials for Medical Devices (ASM International), and The Encyclopedia of Biomedical Engineering (Elsevier). He has previously served as director of the TMS Functional Materials Division and the ASM International Emerging Technologies Awareness Committee; he currently serves as chair of the American Ceramic Society Bioceramics Division. As the 2016-7 ASME Swanson Fellow, Dr. Narayan worked with America Makes, the US national additive manufacturing institute, on several activities to disseminate additive manufacturing technology, including the development of an workforce/education/outreach roadmap for additive manufacturing, and the development of a repository containing educational materials related to additive manufacturing. Dr. Narayan has received several honors for his research activities, including the NCSU Alcoa Foundation Engineering Research Achievement Award, the University of North Carolina Jefferson-Pilot Fellowship in Academic Medicine, the National Science Faculty Early Career Development Award, the Office of Naval Research Young Investigator Award, and the American Ceramic Society Richard M. Fulrath Award. He has been elected as Fellow of AAAS, ASM International, AIMBE, and American Ceramic Society.

Affiliations and Expertise

Professor, Joint Department of Biomedical Engineering at the University of North Carolina and North Carolina State University

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