Diagnostic Reasoning

Diagnostic Reasoning

Laboratory-Based Case Studies in Clinical Chemistry

1st Edition - January 1, 2023

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  • Author: Ibrahim Hashim
  • Paperback ISBN: 9780128229507

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Training in clinical chemistry is acquired via different avenues that include didactic lectures on pathophysiology of disease, methodologies and practical aspects of testing, and through attendance of operations meetings, sign-out sessions, seminars and tutorials. There is little instruction on how to apply the vast amount of knowledge gained in the process to practice. In other branches of medicine, cases are regularly presented with clinical information and therapeutic interventions which form the basis of training. Diagnostic Reasoning: Laboratory-Based Case Studies in Clinical Chemistry fills this gap for clinical chemistry. The concise and practical approach of the book, including real-life scenarios, is an excellent resource for pathology trainees, clinical laboratory science students, clinical chemistry fellows, clinical laboratory professionals, and clinicians. These cases help professionals remain competent in the field and be successful in their board exams. The cases are stated as they present, often with no or few clinical details accompanying the sample request with only barcoded samples arriving into the laboratory. In a busy laboratory, thousands of these cases are received daily and it is impossible to review the clinical information associated with the specimens.

Key Features

  • There are no books with a similar approach and emphasis
  • Fills the gap in teaching by addressing the subject from a laboratory practical prospective with concomitant application of evidence-based laboratory investigation
  • Presents laboratory data in tabulated format to resemble real-life scenarios, shows list of abbreviations and conversion factors
  • Cases begin with clinical presentation and information not available to those within the clinical laboratory
  • Discusses the differential diagnosis and suggests additional testing or investigations as necessary


Pathology residents, clinical laboratory professionals, clinicians, clinical chemistry fellows, and medical student

Table of Contents

  • 1. Electrolytes/Renal function
    2. Calcium and Bone metabolism
    3. Liver
    4. Cardiac
    5. Proteins and Lipids
    6. Endocrine
    7. Oncology
    8. Acid - Base balance
    9. General Analytics and Interferences
    10. Metabolism
    11. Inborn errors of metabolism
    12. Therapeutics

    a. Therapeutic Drug Monitoring
    b. Toxicology

Product details

  • No. of pages: 315
  • Language: English
  • Copyright: © Elsevier 2023
  • Published: January 1, 2023
  • Imprint: Elsevier
  • Paperback ISBN: 9780128229507

About the Author

Ibrahim Hashim

Dr. Ibrahim Hashim is Professor of Pathology, Chief of Clinical Pathology and Clinical Chemistry, and Director at the University of Texas Southwestern Medical Center (UTSW) at Dallas, Texas. He has over 29 years of experience as a clinical chemist and an educator. His work experience includes large university teaching hospitals in the United Kingdom and United States. In addition to directing the Clinical Chemistry Fellowship Program, he gives clinical chemistry didactic lectures to pathology residents, fellows and clinical laboratory scientists. He also lectures on the Fundamentals for Clinical Reasoning course to medical students at UTSW. He is the director of the Clinical Chemistry and the Laboratory Management Rotations for the Pathology Residency program at UTSW and regularly contributes to the scientific literature on clinical chemistry and clinical laboratory topics. Dr. Hashim served as Director on the American Board of Clinical Chemistry and has co-authored Endocrine Society Practice Guidelines on Hypopituitarism.

Affiliations and Expertise

Professor of Pathology, Chief of Clinical Pathology and Clinical Chemistry; Director, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA

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