Diagnostic Pathology: Kidney Diseases

Diagnostic Pathology: Kidney Diseases

3rd Edition - April 29, 2019
  • Authors: Robert Colvin, Anthony Chang
  • eBook ISBN: 9780323711500
  • Hardcover ISBN: 9780323661089

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Comprehensive and up to date, the third edition of Diagnostic Pathology: Kidney Diseases, written by Robert B. Colvin, MD and Anthony Chang, MD, expertly covers all aspects of common and rare renal diseases and their variants. This easy-to-use, point-of-care reference offers a state-of-the-art, concise presentation of major pathological, clinical, pathophysiological, and genetic information for more than 240 diagnoses, making it an ideal resource for pathologists and nephrologists to improve knowledge and skills. Significantly revised information throughout ensures that you remain current with everything new regarding the pathology and pathogenesis of nonneoplastic kidney diseases.

Table of Contents

  • Introduction

    Introduction and Overview

    Introduction to Renal Pathology

    Normal Kidney Structure

    Normal Kidney Development

    Glomerular Diseases


    Minimal Change Disease

    Classification of FSGS

    Etiologic Classification of FSGS

    FSGS, Primary

    FSGS, Adaptive (Secondary)

    Collapsing Glomerulopathy

    Membranous Glomerulonephritis

    Etiologic Classification of Membranous Glomerulonephritis

    Membranous Glomerulonephritis, Primary

    Membranous Glomerulonephritis, Secondary

    Membranous Glomerulonephritis With Anti-TBM Antibodies

    C3-Related Glomerulonephritis and Membranoproliferative Glomerulonephritis

    Classification of MPGN and Complement-Related Diseases

    Dense Deposit Disease

    C3 Glomerulonephritis

    Membranoproliferative Glomerulonephritis With Immune Complexes

    IgA-Related Glomerulonephritis

    Overview of IgA-Related Glomerulopathies

    IgA Nephropathy

    IgA Vasculitis (Henoch-Schönlein Purpura)

    SLE and Related Autoantibody-Mediated GN

    Systemic Lupus Erythematosus

    Mixed Connective Tissue Disease

    Rheumatoid Arthritis

    Mixed Cryoglobulinemic Glomerulonephritis

    Idiopathic Nonlupus Full-House Nephropathy

    Anti-GBM Nephritis

    Anti-GBM Glomerulonephritis

    Atypical Anti-GBM Nephritis

    Monoclonal Immunoglobulin Diseases

    Introduction to Diseases With Monoclonal Immunoglobulin Deposits

    Monoclonal Immunoglobulin Deposition Disease

    Proliferative Glomerulonephritis With Monoclonal IgG Deposits

    Membranous Glomerulonephritis With Masked IgG κ Deposits

    Type I Cryoglobulinemic Glomerulonephritis

    Waldenström Macroglobulinemia


    Amyloidosis Classification

    AL/AH Amyloidosis

    AA Amyloidosis

    AFib Amyloidosis

    AGel Amyloidosis

    ALECT2 Amyloidosis

    AApoAI Amyloidosis

    ApoAII Amyloidosis

    AApoAIV Amyloidosis

    AApoCII Amyloidosis

    ATTR Amyloidosis

    Idiopathic Fibrillary Glomerulopathies

    Diseases With Organized Deposits

    Fibrillary Glomerulopathy

    Immunotactoid Glomerulopathy

    Fibronectin Glomerulopathy

    Diabetic Renal Disease

    Diabetic Nephropathy

    Idiopathic Nodular Glomerulopathy

    Infection-Related Glomerular Disease

    Overview of Infection-Related Glomerular Disease

    Acute Poststreptococcal Glomerulonephritis

    Acute Postinfectious Glomerulonephritis, Nonstreptococcal

    IgA Acute Glomerulonephritis Associated With *Staphylococcus aureus*

    Glomerulonephritis of Chronic Infection, Including Shunt Nephritis



    Lyme Disease

    Hepatitis B Virus

    Hepatitis C Virus

    HIV-Associated Nephropathy

    Miscellaneous HIV-Associated Renal Diseases




    Drug Induced Glomerular Diseases

    Drug-Induced Minimal Change Disease

    Bisphosphonate-Induced Collapsing Glomerulopathy

    Chloroquine Toxicity

    Anti-Hepatitis C Virus Drugs

    Anti-EGFR Drugs

    Genetic Diseases of the Glomerulus

    Overview and Classification of Genetic Diseases of the Glomerulus

    Genetic Diseases of the Glomerular Basement Membrane Collagen

    Alport Syndrome

    Thin Basement Membrane Disease

    Genetic Diseases of the Podocyte

    Diffuse Mesangial Sclerosis

    Congenital Nephrotic Syndrome of the Finnish Type

    Pierson Syndrome

    Galloway-Mowat Syndrome

    Denys-Drash Syndrome

    Frasier Syndrome

    Podocin Deficiency

    Alpha-Actinin-4 Deficiency

    Autosomal Dominant FSGS Due to *INF2* Mutations

    *APOL1*-Related Glomerular Disease

    Schimke Immuno-Osseous Dysplasia

    Genetic Storage and Lipid Diseases

    Lecithin-Cholesterol Acyltransferase Deficiency

    APOE Lipoprotein Glomerulopathy

    Type III Hyperlipoproteinemia

    Fabry Disease

    Gaucher Glomerulopathy

    I-Cell Disease (Mucolipidosis II)

    Alagille Syndrome

    Other Genetic Diseases Affecting the Glomerulus

    Glomerulopathy of Hereditary Multiple Exostoses

    Type III Collagen Glomerulopathy

    Nail-Patella Syndrome

    Miscellaneous Glomerular Diseases

    C1q Nephropathy

    IgM Nephropathy

    Cryofibrinogenic Glomerulopathy

    Hepatic Glomerulosclerosis and IgA Deposition

    Hemophagocytic Glomerulopathy

    Podocyte Infolding Glomerulopathy

    Metabolic Syndrome/Obesity-Related Glomerular Disease

    Intravascular Large B-Cell Lymphoma

    Vascular Diseases

    Overview and Classification of Systemic Vasculitides

    ANCA Disease

    ANCA-Related Glomerulonephritis

    Microscopic Polyangiitis

    Granulomatosis With Polyangiitis

    Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

    Drug-Induced ANCA Vasculitis

    Non-ANCA Vasculitides

    Polyarteritis Nodosa

    Kawasaki Disease

    Giant Cell Arteritis

    Takayasu Arteritis

    Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis)

    Thrombotic Microangiopathies

    Introduction to Thrombotic Microangiopathies

    Hemolytic Uremic Syndrome, Infection Related

    Thrombotic Microangiopathy, Genetic

    Thrombotic Microangiopathy, Autoimmune

    Thrombotic Microangiopathy, Drug Induced

    Postpartum Hemolytic Uremic Syndrome

    Scleroderma Renal Disease

    Multicentric Castleman Disease

    Other Diseases Affecting the Endothelium

    Preeclampsia, Eclampsia, HELLP Syndrome

    Radiation Nephropathy

    Glomerulopathy of Hereditary Multiple Extoses

    Sickle Cell Nephropathy

    Hypertensive Renal Disease

    Hypertensive Renovascular Disease

    Renal Artery Stenosis

    Fibromuscular Dysplasia


    Thrombotic and Embolic Disease

    Renal Vein Thrombosis

    Renal Artery Thrombosis

    Atheromatous Emboli

    Hydrophilic Polymer Emboli

    Tubulointerstitial Diseases

    Overview and Classification of Tubulointerstitial Diseases

    Differential Diagnosis of Acute Interstitial Nephritis

    Ischemic Injury

    Acute Tubular Injury

    Renal Cortical Necrosis


    Bile Cast Nephropathy

    Immunologic Tubular Disease

    Tubulointerstitial Nephritis With Uveitis

    Sjögren Syndrome

    IgG4-Related Kidney Disease

    Idiopathic Hypocomplementemic Tubulointerstitial Nephritis

    Anti-Tubular Basement Membrane Disease

    Antibrush Border Autoantibody Tubulointerstitial Nephritis


    Tubulointerstiital Nephritis with IgM+ Plasma Cells

    Giant Cell Tubulitis With TBM Deposits

    Monoclonal Immunoglobulin Diseases of Tubules

    Light Chain Cast Nephropathy

    Light Chain Proximal Tubulopathy With Crystals

    Light Chain Proximal Tubulopathy Without Crystals

    Drug-Induced Tubulointerstitial Diseases

    Drug-Induced Acute Interstitial Nephritis

    Drugs That Cause Tubulointerstitial Nephritis

    Checkpoint Inhibitor-Induced Kidney Diseases

    Papillary Necrosis


    Cisplatin Nephrotoxicity

    Osmotic Tubulopathy

    Antiviral Drug Nephrotoxicity

    Acute Phosphate Nephropathy

    Lithium-Induced Renal Disease

    Calcineurin Inhibitor Toxicity

    mTOR Inhibitor Toxicity

    Vancomycin-Induced Cast Nephropathy

    Warfarin Nephropathy

    Illicit Drugs and Opioids

    Toxic Injury

    Lead and Other Heavy Metal Toxins

    Aristolochic Acid Nephropathy

    Balkan Endemic Nephropathy

    Ethylene Glycol Toxicity


    Autosomal Dominant Tubulointerstitial Kidney Disease

    Autosomal Dominant Tubulointerstitial Kidney Disease, *MUC1*-Related

    Autosomal Dominant Tubulointerstitial Kidney Disease, *UMOD*-Related

    Autosomal Dominant Tubulointerstitial Kidney Disease, *REN*-Related

    Autosomal Dominant Tubulointerstitial Kidney Disease, *HNF1B*-Related

    Genetic Crystal Depostion Diseases

    Primary Hyperoxaluria



    Uric Acid Nephropathy/Gout

    Genetic Transport Diseases

    Bartter Syndrome

    Dent Disease

    Oculocerebrorenal Syndrome of Lowe

    Other Genetic Diseases Affecting Tubules

    Methylmalonic Acidemia

    Systemic Karyomegaly


    Miscellaneous Tubulointerstitial Diseases


    Secondary Oxalosis

    Mesoamerican Nephropathy

    Extramedullary Hematopoiesis

    Infections of the Kidney

    Bacterial Infections of the Kidney

    Acute Pyelonephritis

    Chronic Pyelonephritis

    Xanthogranulomatous Pyelonephritis



    BCG Granulomatous Interstitial Nephritis


    Megalocytic Interstitial Nephritis



    Whipple Disease

    Fungal, Rickettsial, and Parasitic Infections of the Kidney










    Rickettsial Infections



    Viral Infections of the Kidney

    Polyomavirus Nephritis

    Cytomegalovirus Infection

    Adenovirus Infection

    Epstein-Barr Virus Nephritis

    Herpes Simplex Acute Nephritis

    Hantavirus Nephropathy

    Developmental Diseases

    Overview of Congenital Anomalies of the Kidney and Urinary Tract



    Ectopia, Malrotation, Duplication, Fusion, Supernumerary Kidney

    Ask-Upmark Kidney

    Renal Tubular Dysgenesis

    Cystic Diseases

    Overview of Cystic Diseases


    Autosomal Dominant Polycystic Kidney Disease

    Autosomal Recessive Polycystic Kidney Disease

    Nephronophthisis and Related Ciliopathies

    Other Genetic Cystic Diseases

    von Hippel-Lindau Disease

    Tuberous Sclerosis Complex

    Zellweger Syndrome

    Miscellaneous Cystic Diseases

    Medullary Sponge Kidney

    Mixed Epithelial and Stromal Tumor Family

    Pediatric Cystic Nephroma

    Acquired Cystic Disease

    Simple and Miscellaneous Cysts

    Renal Lymphangioma/Lymphangiectasia

    Diseases of the Collecting System

    Introduction to Impediments to Urine Flow

    Reflux Nephropathy

    Obstructive Nephropathy


    Loin Pain Hematuria Syndrome

    Diseases of the Renal Allograft

    Pathologic Classification of Renal Allograft Diseases


    Evaluation of Allograft Kidney

    Evaluation of the Donor Kidney


    Acute T-Cell-Mediated Rejection

    Chronic T-Cell-Mediated Rejection

    Hyperacute Rejection

    Acute Antibody-Mediated Rejection

    Chronic Antibody-Mediated Rejection

    Transcript Analysis of Renal Transplant Biopsies

    Recurrent and De Novo Diseases

    Diseases That Recur in Allografts

    De Novo FSGS

    De Novo Membranous Glomerulonephritis

    Anti-GBM Disease in Alport Syndrome

    Engraftment Syndrome

    Nonimmunologic Injury

    Acute Allograft Ischemia

    Hyperperfusion Injury

    Urine Leak


    Transplant Renal Artery Stenosis

    Renal Artery or Vein Thrombosis

    Posttransplant Lymphoproliferative Disease

    BK Polyomavirus Neoplasia

    Stable and Accepted Grafts

    Protocol Biopsies



    Kidney Pathology in Recipients of Other Transplants

    Kidney Diseases in Nonrenal Transplant Recipients

    Graft-vs.-Host Glomerulopathies


    Biopsy Reports

    Kidney Needle Biopsy: Evaluation for Adequacy

    Evaluation of Fibrosis

    Immunofluorescence on Paraffin Tissue Sections

    EM Processing From Paraffin or Frozen Tissue

    Detection of PLA2R Deposits and Autoantibodies

    Alport Collagen IV Immunofluorescence

    C4d Immunohistochemistry/Immunofluorescence

    Polyomavirus Detection in Tissue

    Mass Spectrometry

    Diagnostic Genetics of Kidney Diseases

    Examination of the End-Stage Kidney

    Examination of Tumor Nephrectomy Specimens for Nonneoplastic Diseases

    Evaluation of the Transplant Nephrectomy

    Evaluation of Autopsy Kidneys

Product details

  • No. of pages: 1176
  • Language: English
  • Copyright: © Elsevier 2019
  • Published: April 29, 2019
  • Imprint: Elsevier
  • eBook ISBN: 9780323711500
  • Hardcover ISBN: 9780323661089

About the Authors

Robert Colvin

Affiliations and Expertise

Benjamin Castleman Distinguished Professor of Pathology, Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts

Anthony Chang

Anthony C. Chang MD, MBA, MPH, MS After his cardiology training at the Children’s Hospital of Philadelphia with his research interest in mathematics and chaos theory in biomedicine, Dr. Anthony Chang was an attending cardiologist in the cardiovascular intensive care unit of Boston Children’s Hospital and an assistant professor at Harvard Medical School. Throughout his career as a pediatric cardiac intensive care physician, he has been interested in applications of biomedical data to decision-making. He completed his Masters of Science (MS) in Data Science with a sub-specialization in artificial intelligence from Stanford School of Medicine. He is also a computer scientist-in-residence at Chapman University. He is currently the Chief Intelligence and Innovation Officer and Medical Director of the Heart Failure Program at Children’s Hospital of Orange County. He is the founder and medical director of the Medical Intelligence and Innovation Institute (MI3) that is supported by the Sharon Disney Lund Foundation. The institute, founded in 2015, is dedicated to the introduction and implementation of artificial intelligence in medicine and was the first institute of its kind in a hospital. He intends to build a clinician-computer scientist interface with a nascent society (the Medical Intelligence Society) and is the editor-in-chief of Intelligence-based Medicine, the accompanying journal for his book, Intelligence-Based Medicine: Artificial Intelligence and Human Cognition in Clinical Medicine and Healthcare. He is the organizing chair for Artificial Intelligence in Medicine (AIMed) meetings around the world, the largest and most comprehensive clinician-led meetings that focus on applications of artificial intelligence in medicine and the dean of the nascent American Board of Artificial Intelligence in Medicine (ABAIM). He is also the founding president of the Medical Intelligence Society (MIS).

Affiliations and Expertise

Chief Intelligence and Innovation Officer (CIIO), Heart Failure Program, Children's Hospital of Orange County, CA, United States of America; Medical Director, Heart Failure Program, Children's Hospital of Orange County, CA, United States of America