Diagnostic Molecular Biology - 1st Edition - ISBN: 9780128028230

Diagnostic Molecular Biology

1st Edition

Authors: Chang-Hui Shen
Paperback ISBN: 9780128028230
Imprint: Academic Press
Published Date: 29th March 2019
Page Count: 476
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Diagnostic Molecular Biology describes the fundamentals of molecular biology in a clear, concise manner to aid in the comprehension of this complex subject. Each technique described in this book is explained within its conceptual framework to enhance understanding, and current applications of clinical laboratory techniques are covered in detail.

The targeted approach covers the principles of molecular biology including the basic knowledge of nucleic acids, proteins, and genomes; the basic techniques and instrumentations that are often used in the field of molecular biology with detailed procedures and explanations; and the applications of the principle and techniques currently employed in the clinical laboratory.

Key Features

  • Provides an understanding of what techniques are used to diagnosis at the molecular level
  • Explains how to use information technology to communicate and assess results in the lab
  • Places protocols into context with practical applications


Researchers and technicians in the lab, pathologists, and students in molecular biology and microbiology

Table of Contents

Part I
1. Introduction
2. Genes
3. Nucleic acids based cellular activities
4. Genes encode polypeptides
5. Genome

Part II
6. Extraction and purification of nucleic acids and proteins
7. Detection and analysis of nucleic acids and proteins
8. Characterization of nucleic acids and proteins
9. Amplification of nucleic acids
10. Genes and genomes sequencing techniques
11. Techniques in studying gene expression and function
12. Techniques in studying genomes

Part III
13. Techniques in human identification
14. Molecular diagnosis of mutation and inherited diseases
15. Molecular diagnosis of microorganisms and infectious diseases
16. Molecular diagnosis of cancers
17. Safety and quality management in clinical medical laboratory


No. of pages:
© Academic Press 2019
Academic Press
Paperback ISBN:

About the Author

Chang-Hui Shen

Dr. Shen is a Professor of Biology and currently serves as Chair of the Biology Department at the College of Staten Island, City University of New York, New York. Dr. Shen graduated from the National Chung-Hsing University, Taiwan, with both a BS and MS, earning his PhD from the University of Edinburgh, UK. He previously was a visiting fellow of the National Institutes of Health before moving onto the College of Staten Island. In his laboratory, Dr. Shen’s research focuses on understanding the mechanism of gene expression, with an emphasis on the roles of transcriptional coactivators in gene activation. His research also focuses on the regulation of programmed cell death through major cellular signal transduction pathways and transcriptional networks in the cell, as well as the epigenetic regulation of neurodegenerative diseases. Dr. Shen has been teaching Diagnostic Molecular Biology for more than 15 years.

Affiliations and Expertise

Professor of Biology and Chair of the Biology Department at the College of Staten Island, City University of New York, New York

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