Diagnosis, Management and Modeling of Neurodevelopmental Disorders

Diagnosis, Management and Modeling of Neurodevelopmental Disorders

The Neuroscience of Development

1st Edition - May 29, 2021

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  • Editors: Colin Martin, Victor Preedy, Rajkumar Rajendram
  • eBook ISBN: 9780128179895
  • Hardcover ISBN: 9780128179888

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Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. In addition, the book also examines the pharmacological and non-pharmacological interventions of development-related conditions.

Key Features

  • Provides the most comprehensive coverage of the broad range of topics relating to the neuroscience of aging
  • Features sections on the genetics that influences aging and diseases of aging
  • Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter
  • Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations
  • Includes more than 500 illustrations and tables


Neuroscientists, geriatricians, neurobiologists, experimental biologists, clinicians, graduate students, and post-doctoral fellows

Table of Contents

  • I. Introductory chapters: Setting the scene for the neuroscience of development
    1. The structure of the human brain as revealed in six histological sections
    Richard Armstrong
    2. Neural tube defects: embryonic origin, cell survival equilibrium impact, and clinical features
    Chiara Parodi, Paolo Grazioli, Laura Avagliano, Timothy M. George, Gaetano P. Bulfamante, Richard H. Finnell and Valentina Massa
    3. Chemical substances affecting neurodevelopment
    Munekazu Komada
    4. High-risk babies and neurodevelopmental outcome
    Merina Shrestha
    5. Genomic imprinting and neurodevelopment
    Ines Lopez del Castillo, Anna Lozano-Ureña and Sacri R. Ferron
    6. Insights from model systems: alcohol, neurodevelopment and zebrafish
    Robert Gerlai
    7. Maternal iodine nutrition and neurodevelopment in the offspring
    Shao Jia Zhou
    8. Endocrine aspects of development. Thyroid hormone actions in neurological processes during brain development
    Ana Montero-Pedrazuela, Carmen Grijota-Martınez, Eva Auso, Soledad Barez-Lopez and Ana Guadaño-Ferraz

    II. Impairments and Diseases
    9. Pediatric brain tumors
    Sherif G. Shaaban and Stephanie A. Terezakis
    10. Neurofibromatosis type 1: from cellular phenotypes to human brain function
    Ines Bernardino, Joana Goncxalves and Miguel Castelo-Branco
    11. Current insights into neural crest cell development and pathologies
    Rebekah M. Charney, Maneeshi S. Prasad and Martın I. Garcıa-Castro
    12. Spina Bifida: a biopsychosocial perspective
    Diana M. Ohanian, Adrien M. Winning, Laura M. Nicholson and Grayson N. Holmbeck
    13. Diabetic ketoacidosis and neurodevelopment
    Walter Zegarra and Tandy Aye
    14. Four-dimensional features of fetal brain: applications to diabetes
    Panagiotis Antsaklis, George Daskalakis and Asim Kurjak
    15. Developmental effects of nicotine on cognitive, motivated, and executive behaviors
    Kristi A. Kohlmeier and Filip S. Polli
    16. Maternal methamphetamine and impact on the developing brain
    Romana Slamberova and Kateryna Nohejlova
    17. Alcohol, cannabis and brain development
    Kristen Rian Breit
    18. The environmental pollutant trichloroethylene disrupts key neural pathways during brain development
    Briana R. De Miranda and Sarah J. Blossom
    19. Developmental neurotoxicity of the herbicide atrazine
    Janiel Ahkin Chin Tai and Jennifer L. Freeman
    20. Neurodevelopmental delays and in utero exposure to hyperemesis gravidarum
    Marlena S. Fejzo and Patrick M. Mullin
    21. Neurodevelopment and PCDH19-related developmental and epileptic encephalopathy (PCDH19-DDE)
    Silvia Bassani, Carla Marini and Maria Passafaro
    22. Neurodevelopment in turner syndrome
    Reid Blanchett and Rebecca C. Knickmeyer
    23. Very preterm children and the impact on neurodevelopmental outcomes
    Leona Pascoe and Peter J. Anderson
    24. Linking congenital heart disease and brain functional connectivity in newborns
    Josepheen De Asis-Cruz and Catherine Limperopoulos
    25. Brain growth in congenital heart disease from prenatal environment to adulthood
    Cynthia Ortinau
    26. Adolescent dopamine development: connecting experience with vulnerability or resilience to psychiatric disease
    Lauren M. Reynolds and Cecilia Flores
    27. Developmental coordination disorder
    Jill Glennis Zwicker

    III. Biomarkers, screening, methods and diagnosis
    28. Neurodevelopment and the Ages and Stages Questionnaire, third edition (ASQ-3)
    N. Granana and A.M. Romero Otalvaro
    29. Attention deficit hyperactivity disorder screening in childhood and adolescence
    Steven James Korzeniewski
    30. The Mini-Mental State Pediatric Examination: a cognitive screening test for Italian children
    Valeria Peviani, Pina Scarpa and Gabriella Bottini
    31. Predictors of neurodevelopment in preterm infants: from the neonatal intensive care unit into adulthood
    Pilar Medina-Alva
    32. Antenatal fetal neurodevelopment test: KANET assessment
    Toshiyuki Hata and Mohamed Ahmed AboEllail

    IV: Management and treatments
    33. Pain evaluation and management in neurodevelopmental conditions
    Marlon L. Wong and Eva Widerstrom-Noga
    34. Use of levetiracetam in neonates: features and applications (a narrative review)
    Shannon Pollock and Louis N. Manganas
    35. Quetiapine treatment in paediatric scenarios
    Barbara Plemeniti Tololeski and Maja Drobnic Radobuljac
    36. Treatments with cannabinoids and brain development
    P. Schonhofen, D.M. Vargas, R.B. Parsons and Fabio Klamt
    37. Deep brain stimulation for pediatric dystonia: neurophysiological, behavioral, and functional changes and their clinical relevance
    Lior M. Elkaim and George M. Ibrahim
    38. Use of repetitive transcranial magnetic stimulation in neurodevelopment: A narrative review
    Yoshihiro Noda
    39. Cognitive behavioral therapy in children with anxiety disorders
    Gabrielle Gloston, Michael A. Sustaita, Ana C. Ramirez, Saira A. Weinzimmer, Andres G. Viana, Eric A. Storch and Sophie C. Schneider
    40. Cognitive behavioral therapy for anxiety in children with autism spectrum disorder
    Ana C. Ramirez, Mayra I. Perez, Danica Limon, Eric A. Storch and Sophie C. Schneider
    41. Nutritional treatment in fetal alcohol spectrum disorder (FASD)
    Oscar Garcıa-Algar, Giorgia Sebastiani, Vicente Andreu- Ferna42. Nurturing the developing brain to reduce neurological delay
    Kelly A. Vaughn, Bartlett D. Moore, IV and Dana DeMaster
    43. Normalizing perinatal neurological development via intervention
    Dana DeMaster, Kelly A. Vaughn and Bartlett D. Moore, IV

    V. Models and modelling
    44. Microplatforms as a model for neurological conditions
    George Deeb, Zeina Bou Diab, Jessica Saliba, Arij Daou and Rami Mhanna
    45. Disease models in neurodevelopmental disorders
    Pietro Fazzari, Angela Rodriguez-Prieto and Maximo Ibo Galindo
    46. Developmental neurotoxicity of endosulfan: modeling with zebrafish
    Karina Dale, Josef Daniel Rasinger and Ståle Ellingsen
    47. Neurodevelopment of the zebrafish spinal serotonin system
    Mark A. Masino and Jacob E. Montgomery
    48. Inbred mouse model of brain development and intestinal microbiota
    Reinaldo B. Oria, Daniel V. Pinto, Ronaldo P. Dias, Ramon S. Raposo, Patricia L. Foley, Joaeo O. Malva and Richard L. Guerrant
    49. The myelin mutant taiep rat as a model for developmental brain disorders
    Jose R. Eguibar, Carmen Cortes, Juan C. Ahumada-Juarez, Valeria Piazza and Victor Hugo Hernandez Gonzalez
    50. The MAM-E17 neurodevelopmental model of schizophrenia
    Marzena Mackowiak

    VI. Resources
    51. Recommended resources on the neuroscience of development
    Rajkumar Rajendram and Victor R. Preedy

Product details

  • No. of pages: 624
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: May 29, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128179895
  • Hardcover ISBN: 9780128179888

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

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