Diagnosis and Management in Dementia

Diagnosis and Management in Dementia

The Neuroscience of Dementia, Volume 1

1st Edition - August 11, 2020

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  • Editors: Colin Martin, Victor Preedy
  • eBook ISBN: 9780128158555
  • Hardcover ISBN: 9780128158548

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Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1 consolidates different fields of dementia into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. With an impact on millions globally, and billions of research dollars being invested in dementia research, this book will stimulate research in the area and inform researchers.

Key Features

  • Offers comprehensive coverage of a broad range of topics related to dementia
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about dementia


Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. Graduate/postgraduate students, lecturers, and professors

Table of Contents

  • Part I: Dementia: introductory chapters and setting the scene

    1. Mixed dementia: a neuropathological overview
    Jacques De Reuck

    2. Vascular dementia: an overview
    Virginia Cipollini, Fernanda Troili and Franco Giubilei

    3. Small vessel disease and dementia
    Francesco Arba and Valentina Rinnoci

    4. Linking amyotrophic lateral sclerosis and frontotemporal dementia
    Couratier Philippe

    5. Mortality in dementia: linking in the role of delirium
    Flavia Barreto Garcez and Thiago Junqueira Avelino-Silva

    6. Midlife diabetes and the risk of dementia: understanding the link
    Adam H. Dyer and Sean P. Kennelly

    7. Gait and dementia
    Oshadi Jayakody and Michele L. Callisaya

    8. The role of blood pressure and hypertension in dementia
    Keenan A. Walker and Rebecca F. Gottesman

    9. Genetics of dementia: a focus on Alzheimer’s disease
    Francesca Fernandez and Jessica L. Andrews

    10. Clinical and pathological phenotypes in dementia: a focus on autosomal dominant frontotemporal dementia
    Innocenzo Rainero, Alessandro Vacca and Elisa Rubino

    11. Environmental and genetic risk factors for dementia
    Vanesa Bellou, Lazaros Belbasis and Evangelos Evangelou

    12. Lipids, brain ageing, dementia, and lipidomics
    Anne Poljak, Braidy Nady, Wong Matthew Wai Kin, Yue Liu, Mahboobeh Housseini and Sachdev Perminder Singh

    13. The 5xFAD mouse model of Alzheimer’s disease
    Caroline Ismeurt, Patrizia Giannoni and Sylvie Claeysen

    Part II: Biomarkers, psychometric instruments and diagnosis

    14. Use of cerebrospinal fluid in diagnosis of dementia
    Angelo Nuti, Cecilia Carlesi, Elena Caldarazzo Ienco, Gabriele Cipriani and Paolo Del Dotto

    15. Salivary biomarkers in Alzheimer’s disease
    Jessica L. Andrews and Francesca Fernandez

    16. Diacylglycerols: biomarkers of a sustained immune response in proteinopathies
    Paul L. Wood and Randall J. Woltjer

    17. Butyrylcholinesterase as a biomarker in Alzheimer’s disease
    Drew R. DeBay and Sultan Darvesh

    18. Blood brain-derived neurotrophic factor as a biomarker of Alzheimer’s disease
    Marta Balietti

    19. The neuroscience of dementia: diagnosis and management methods of amyloid positron emission tomography imaging and its application to the Alzheimer’s disease spectrum
    Shizuo Hatashita

    20. Diffusion-weighted imaging (DWI) tractography and Alzheimer’s disease
    Nicola Amoroso

    21. Transcranial magnetic stimulation in the cortical exploration of dementia
    Thanuja Dharmadasa, William Huynh and Matthew C. Kiernan

    22. The role of retinal imaging in Alzheimer’s disease
    Victor T.T. Chan and Carol Y. Cheung

    23. Prediction of Alzheimer’s disease
    Athanasios Alexiou, Stylianos Chatzichronis and Ghulam Md Ashraf

    24. Addenbrooke’s Cognitive Examination
    Jordi A. Matias-Guiu

     25. Beyond the cutoffs: a Bayesian approach to the use of the Montreal Cognitive Assessment as a screening tool for mild cognitive impairment and dementia
    Andrea Bosco, Alessandro O. Caffo, Giuseppina Spano and Antonella Lopez

    26. Utility of ALBA screening instrument: the prodromal phase of dementia with Lewy bodies
    Waleska Berríos and Angel Golimstok

    27. The quick mild cognitive impairment screen and applications to dementia
    Ron an O’Caoimh, D. William Molloy and Roger Clarnette

    28. The usefulness of evaluating performance of activities of daily living in the diagnosis of mild cognitive disorders
    Patricia De Vriendt, Elise Cornelis and Ellen Gorus

    Part III: Pharmacological treatments for dementia

    29. Cholinesterase inhibitors in dementias: an overview
    Patrizia Mecocci, Lucia Paolacci and Virginia Boccardi

    30. Choline-containing phospholipids and treatment of adult-onset dementia disorders
    Francesco Amenta, Gopi Battineni, Enea Traini and Graziano Pallotta

    31. Donepezil in the treatment of Alzheimer’s disease
    Gabriella Marucci, Michele Moruzzi and Francesco Amenta

    32. Memantine and Alzheimer’s disease: a comprehensive review
    Sergio del Río-Sancho

    33. A new neuroprotective strategy for the drug therapy of Parkinson’s disease: the Ca2þ/cAMP signaling as therapeutic target
    Afonso Caricati-Neto, Fulvio Alexandre Scorza and Leandro Bueno Bergantin

    34. Pitfalls and possible solutions for research and development of dementia therapies
    Thomas Muller €

    35. All-trans retinoic acid in Alzheimer’s disease
    Siamak Beheshti

    36. Dementia and usage of N-methyl-D-aspartate receptor antagonists
    B.E. Glynn-Servedio

    37. Swallowing impairment in Parkinson’s disease
    Maira Rozenfeld Olchik, Marina Padovani and Annelise Ayres

    38. Linking astrocytes’ exosomes to Alzheimer pathogenesis and therapy
    Anna M. Chiarini, Ubaldo Armato, Claudio Eccher and Ilaria Dal Pr

    39. Changing fate: therapeutic mechanisms focused on the switch of amyloid precursor protein processing
    Sven Reinhardt and Kristina Endres

    40. Acetylcholinesterase inhibitory agents in plants and their application to dementia: Alzheimer’s disease
    Willian Orlando Castillo-Ordonez and Nohelia Cajas-Salazar

    41. Removal of blood amyloid-b as an effective and safe therapeutic strategy
    Nobuya Kitaguchi, Kazunori Kawaguchi and Kazuyoshi Sakai

    Part IV: Non-pharmacological treatments and procedures

    42. Caring for people with dementia in the acute hospital
    Robert Briggs, Paul Claffey and Sean P. Kennelly

    43. Environmental enrichment as a preventative and therapeutic approach to Alzheimer’s disease
    Kimberley E. Stuart, Anna E. King and James C. Vickers

    44. Music therapy in dementia: the effects of music therapy and other musical interventions on behavior, emotion, and cognition
    Alfredo Raglio and Lapo Attardo

    45. Exploitation of aromatherapy in dementiadimpact on pain and neuropsychiatric symptoms
    Damiana Scuteri, Laura Rombol

    46. Dancing in dementia
    Lee-Fay Low, Helen Parker, Kathryn Dovey and Alycia Fong Yan

    47. Hypoxicehyperoxic conditioning and dementia
    Robert T. Mallet, Johannes Burtscher, Eugenia B. Manukhina, H. Fred Downey, Oleg S. Glazachev, Tatiana V. Serebrovskaya and Martin Burtscher

    48. Linking amyloid and depression in the development of Alzheimer’s disease: effects of neuromodulatory interventions by brain stimulation
    Akihiko Nunomura, Toshio Tamaoki, Kenji Tagai, Shinsuke Kito, Shunichiro Shinagawa and Masahiro Shigeta

    49. Regional and local dementia care networks
    Franziska Laporte Uribe, Karin Wolf-Ostermann, Jochen Rene Thyrian and Bernhard Holle

    50. Cognitive behavioral therapy use in Alzheimer’s disease: mitigating risks associated with the olfactory brain
    Larry D. Reid, Dylan Z. Taylor and Alicia A. Walf

    51. Maximizing cognition in mild cognitive impairment and early stage dementia
    Bridget Regan, Yvonne Wells and Paul O’Halloran

    52. Exercise, cognitive creativity, and dementia
    Emily Frith and Paul D. Loprinzi

    53. Person-centered communication among formal caregivers of persons with dementia
    Marie Y. Savundranayagam and Pabiththa Kamalraj


Product details

  • No. of pages: 910
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: August 11, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128158555
  • Hardcover ISBN: 9780128158548

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is Emeritus Professor of Nutritional Biochemistry, at King’s College London and Professor of Clinical Biochemistry (Hon) at King’s College Hospital. He was the long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof. Preedy is a leading expert on the science of health and has a long-standing interest in dietary and plant-based components. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Emeritus Professor, King’s College London; Professor, King’s College Hospital, London, UK

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