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Diagnosis and Management in Dementia - 1st Edition - ISBN: 9780128158548

Diagnosis and Management in Dementia

1st Edition

The Neuroscience of Dementia, Volume 1

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Editors: Colin R. Martin Victor Preedy
Hardcover ISBN: 9780128158548
Imprint: Academic Press
Published Date: 1st August 2020
Page Count: 835
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Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1 consolidates different fields of dementia into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. With an impact on millions globally, and billions of research dollars being invested in dementia research, this book will stimulate research in the area and inform researchers.

Key Features

  • Offers comprehensive coverage of a broad range of topics related to dementia
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about dementia


Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. Graduate/postgraduate students, lecturers, and professors

Table of Contents


Carolyn Roberts


I. Dementia: Introductory Chapters and Setting the Scene

1. Mixed dementia: an overview

Jaqcues J. De Reuck

2. Vascular dementia: an overview

Virginia Cipollini

3. Small vessel disease and dementia

Francesco Arba

4. Linking Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia

Philippe Couratier

5. Mortality in dementia: linking in delirium

Thiago Silva

6. Midlife diabetes and the risk of dementia- understanding the link

Sean Kennelly and Adam H. Dyer

7. Gait and Alzheimer's disease /Gait and dementia

Michele Linda Callisaya

8. Hypertension and dementia

Rebecca F. Gottesman

9. Genetics of dementia: focus on Alzheimer’s disease

Francesca Fernandez

10. Clinical and pathological phenotypes in autosomal dominant frontotemporal dementia

Innocenzo Rainero

11. Risk factors in dementia: genetic and nongenetic

Evangelos Evangelou

12. Lipidomics and biomarker in Alzheimer’s disease


13. The 5xFAD mouse model of Alzheimer’s disease

Sylvie Claeysen

II. Biomarkers, Psychometric Instruments And Diagnosis

14. Use of cerebrospinal fluid in diagnosis of dementia

Angelo Nuti

15. Salivary biomarkers in Alzheimer’s disease

Francesca Fernandez

16. Diacylglycerols as biomarkers in dementia

Paul Wood

17. Butyrylcholinesterase (BChE) as a biomarker in Alzheimer’s disease

Sultan Darvesh

18. Blood brain-derived neurotrophic factor as a biomarker of Alzheimers disease

Marta Balietti

19. Methods of amyloid PET Imaging and its applications to Alzheimer’s disease spectrum

Shizuo Hatashita Sr.

20. Applications of diffusion-weighted imaging (DWI) Tractography and Alzheimer’s disease

Nicola Amoroso

21. Transcranial Magnetic stimulation and diagnostic applications to dementias

Matthew Kiernan and Thanuja Dharmasada

22. Retinal imaging and dementia as a diagnostic tool

Carol Y. Cheung

23. The prediction of Alzheimer’s disease

Athanasios Alexiou

24. Addenbrooke's Cognitive Examination

Jordi A. Matias-Guiu

25. The Montreal Cognitive Assessment (MoCA) and applications to dementia

Andrea Bosco

26. ALBA Screening Instrument (ASI) and applications to dementia

Angel Golimstok

27. The Quick Mild Cognitive Impairment (Qmci) screen and applications to dementia

Roger Clarnette

28. Assessment of activities of daily living (ADL) applied to dementia

Patricia De Vriendt

III. Pharmacological Treatments For Dementia

29. Cholinesterase inhibitors in dementias: an overview

Patrizia Mecocci

30. Choline-containing phospholipids and treatment of adult-onset dementia disorders

Francesco Amenta

31. Donepezil usage: a focused review

Francesco Amenta

32. Memantine: a focused review

Sergio del Rio Sancho

33. The benefits of calcium channel blockers for the therapy of dementia

L. Bergantin

34. Pitfalls for pharmacotherapeutic trials in dementia

T. Mueller

35. All-trans retinoic acid in Alzheimer’s disease

Siamak Beheshti

36. Dementias and usage of NMDA receptor antagonists

Brianna E. Glynn-Servedio

37. Dementia and bladder dysfunction: a focus on treatments with anticholinergics 

Ryuji Sakakibara

38. Linking astrocytes' exosomes to Alzheimer's pathogenesis and therapy

Anna Chiarini

39. Changing the fate: therapeutic mechanisms focus on the switch of beta-amyloid precursor protein (APP) processing

Kristina Endres

40. Acetylcholinesterase inhibitory agents in plants and application to dementia: Alzheimers Disease

Willian Orlando Castillo-Ordonez

41. Removal of blood amyloid as a safety strategy

Nobuya Kitaguchi

IV. Non-Pharmacological Treatments and Procedures

42. Caring for people with Dementia in the Acute Hospital

R. Briggs and Sean Kennelly

43. Environmental enrichment in dementia

Kimberley Stuart

44. Music therapy in dementia

Alfredo Raglio and Lapo Attardo

45. Aromatherapy in dementia

G. Bagetta and Damiana Scuteri

46. Dancing in dementia

Lee-Fay Low and Kathryn Dovey

47. Hypoxic-hyperoxic training and dementia

Martin Burtscher

48. Linking amyloid and depression in dementia: effects of treatments by non-drug means

Akihiko Nunomura

49. Regional dementia care networks

Franziska laporte Uribe

50. Cognitive behavioural therapy (CBT) use in Alzheimer’s disease

Alicia Ann Walf

51. Maximizing cognition in Mild Cognitive Impairment and early-stage dementia

Bridget Regan

52. Exercise, cognitive creativity, and dementia

Paul D. Loprinzi

53. Linking care staff, person-focused communications and dementias

Marie Y. Savundranayagam


No. of pages:
© Academic Press 2020
1st August 2020
Academic Press
Hardcover ISBN:

About the Editors

Colin R. Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Perinatal Mental Health, Institute of Clinical and Applied Health Research (ICAHR), University of Hull, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a staff member of the Faculty of Life Sciences and Medicine within King's College London. He is also a member of the Division of Diabetes and Nutritional Sciences (research) and the Department of Nutrition and Dietetics (teaching). Professor Preedy is also Director of the Genomics Centre of King's College London. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctorate (DSc), for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof Preedy is a leading expert on the science of health and has a long standing interest in neurological disease and tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

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