Diagnosis and Management in Dementia

Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1 consolidates different fields of dementia into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. With an impact on millions globally, and billions of research dollars being invested in dementia research, this book will stimulate research in the area and inform researchers.

• Offers comprehensive coverage of a broad range of topics related to dementia
• Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
• Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
• Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
• Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
• Serves as a "one-stop" source for everything you need to know about dementia

Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. Graduate/postgraduate students, lecturers, and professors

Part I: Dementia: introductory chapters and setting the scene

1. Mixed dementia: a neuropathological overview
Jacques De Reuck

2. Vascular dementia: an overview
Virginia Cipollini, Fernanda Troili and Franco Giubilei

3. Small vessel disease and dementia
Francesco Arba and Valentina Rinnoci

4. Linking amyotrophic lateral sclerosis and frontotemporal dementia
Couratier Philippe

5. Mortality in dementia: linking in the role of delirium
Flavia Barreto Garcez and Thiago Junqueira Avelino-Silva

6. Midlife diabetes and the risk of dementia: understanding the link
Adam H. Dyer and Sean P. Kennelly

7. Gait and dementia
Oshadi Jayakody and Michele L. Callisaya

8. The role of blood pressure and hypertension in dementia
Keenan A. Walker and Rebecca F. Gottesman

9. Genetics of dementia: a focus on Alzheimer’s disease
Francesca Fernandez and Jessica L. Andrews

10. Clinical and pathological phenotypes in dementia: a focus on autosomal dominant frontotemporal dementia
Innocenzo Rainero, Alessandro Vacca and Elisa Rubino

11. Environmental and genetic risk factors for dementia
Vanesa Bellou, Lazaros Belbasis and Evangelos Evangelou

12. Lipids, brain ageing, dementia, and lipidomics
Anne Poljak, Braidy Nady, Wong Matthew Wai Kin, Yue Liu, Mahboobeh Housseini and Sachdev Perminder Singh

13. The 5xFAD mouse model of Alzheimer’s disease
Caroline Ismeurt, Patrizia Giannoni and Sylvie Claeysen

Part II: Biomarkers, psychometric instruments and diagnosis

14. Use of cerebrospinal fluid in diagnosis of dementia
Angelo Nuti, Cecilia Carlesi, Elena Caldarazzo Ienco, Gabriele Cipriani and Paolo Del Dotto

15. Salivary biomarkers in Alzheimer’s disease
Jessica L. Andrews and Francesca Fernandez

16. Diacylglycerols: biomarkers of a sustained immune response in proteinopathies
Paul L. Wood and Randall J. Woltjer

17. Butyrylcholinesterase as a biomarker in Alzheimer’s disease
Drew R. DeBay and Sultan Darvesh

18. Blood brain-derived neurotrophic factor as a biomarker of Alzheimer’s disease
Marta Balietti

19. The neuroscience of dementia: diagnosis and management methods of amyloid positron emission tomography imaging and its application to the Alzheimer’s disease spectrum
Shizuo Hatashita

20. Diffusion-weighted imaging (DWI) tractography and Alzheimer’s disease
Nicola Amoroso

21. Transcranial magnetic stimulation in the cortical exploration of dementia
Thanuja Dharmadasa, William Huynh and Matthew C. Kiernan

22. The role of retinal imaging in Alzheimer’s disease
Victor T.T. Chan and Carol Y. Cheung

23. Prediction of Alzheimer’s disease
Athanasios Alexiou, Stylianos Chatzichronis and Ghulam Md Ashraf

24. Addenbrooke’s Cognitive Examination
Jordi A. Matias-Guiu

 25. Beyond the cutoffs: a Bayesian approach to the use of the Montreal Cognitive Assessment as a screening tool for mild cognitive impairment and dementia
Andrea Bosco, Alessandro O. Caffo, Giuseppina Spano and Antonella Lopez

26. Utility of ALBA screening instrument: the prodromal phase of dementia with Lewy bodies
Waleska Berríos and Angel Golimstok

27. The quick mild cognitive impairment screen and applications to dementia
Ron an O’Caoimh, D. William Molloy and Roger Clarnette

28. The usefulness of evaluating performance of activities of daily living in the diagnosis of mild cognitive disorders
Patricia De Vriendt, Elise Cornelis and Ellen Gorus

Part III: Pharmacological treatments for dementia

29. Cholinesterase inhibitors in dementias: an overview
Patrizia Mecocci, Lucia Paolacci and Virginia Boccardi

30. Choline-containing phospholipids and treatment of adult-onset dementia disorders
Francesco Amenta, Gopi Battineni, Enea Traini and Graziano Pallotta

31. Donepezil in the treatment of Alzheimer’s disease
Gabriella Marucci, Michele Moruzzi and Francesco Amenta

32. Memantine and Alzheimer’s disease: a comprehensive review
Sergio del Río-Sancho

33. A new neuroprotective strategy for the drug therapy of Parkinson’s disease: the Ca2þ/cAMP signaling as therapeutic target
Afonso Caricati-Neto, Fulvio Alexandre Scorza and Leandro Bueno Bergantin

34. Pitfalls and possible solutions for research and development of dementia therapies
Thomas Muller €

35. All-trans retinoic acid in Alzheimer’s disease
Siamak Beheshti

36. Dementia and usage of N-methyl-D-aspartate receptor antagonists
B.E. Glynn-Servedio

37. Swallowing impairment in Parkinson’s disease
Maira Rozenfeld Olchik, Marina Padovani and Annelise Ayres

38. Linking astrocytes’ exosomes to Alzheimer pathogenesis and therapy
Anna M. Chiarini, Ubaldo Armato, Claudio Eccher and Ilaria Dal Pr

39. Changing fate: therapeutic mechanisms focused on the switch of amyloid precursor protein processing
Sven Reinhardt and Kristina Endres

40. Acetylcholinesterase inhibitory agents in plants and their application to dementia: Alzheimer’s disease
Willian Orlando Castillo-Ordonez and Nohelia Cajas-Salazar

41. Removal of blood amyloid-b as an effective and safe therapeutic strategy
Nobuya Kitaguchi, Kazunori Kawaguchi and Kazuyoshi Sakai

Part IV: Non-pharmacological treatments and procedures

42. Caring for people with dementia in the acute hospital
Robert Briggs, Paul Claffey and Sean P. Kennelly

43. Environmental enrichment as a preventative and therapeutic approach to Alzheimer’s disease
Kimberley E. Stuart, Anna E. King and James C. Vickers

44. Music therapy in dementia: the effects of music therapy and other musical interventions on behavior, emotion, and cognition
Alfredo Raglio and Lapo Attardo

45. Exploitation of aromatherapy in dementiadimpact on pain and neuropsychiatric symptoms
Damiana Scuteri, Laura Rombol

46. Dancing in dementia
Lee-Fay Low, Helen Parker, Kathryn Dovey and Alycia Fong Yan

47. Hypoxicehyperoxic conditioning and dementia
Robert T. Mallet, Johannes Burtscher, Eugenia B. Manukhina, H. Fred Downey, Oleg S. Glazachev, Tatiana V. Serebrovskaya and Martin Burtscher

48. Linking amyloid and depression in the development of Alzheimer’s disease: effects of neuromodulatory interventions by brain stimulation
Akihiko Nunomura, Toshio Tamaoki, Kenji Tagai, Shinsuke Kito, Shunichiro Shinagawa and Masahiro Shigeta

49. Regional and local dementia care networks
Franziska Laporte Uribe, Karin Wolf-Ostermann, Jochen Rene Thyrian and Bernhard Holle

50. Cognitive behavioral therapy use in Alzheimer’s disease: mitigating risks associated with the olfactory brain
Larry D. Reid, Dylan Z. Taylor and Alicia A. Walf

51. Maximizing cognition in mild cognitive impairment and early stage dementia
Bridget Regan, Yvonne Wells and Paul O’Halloran

52. Exercise, cognitive creativity, and dementia
Emily Frith and Paul D. Loprinzi

53. Person-centered communication among formal caregivers of persons with dementia
Marie Y. Savundranayagam and Pabiththa Kamalraj

Index