Developmental Biology and Musculoskeletal Tissue Engineering - 1st Edition - ISBN: 9780128114674

Developmental Biology and Musculoskeletal Tissue Engineering

1st Edition

Principles and Applications

Editors: Martin J. Stoddart April M. Craft Girish Pattappa Oliver F.W. Gardner
Paperback ISBN: 9780128114674
Imprint: Academic Press
Published Date: 1st June 2018
Page Count: 300
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Description

Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies.

Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells.

Key Features

  • Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes
  • Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues
  • Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering
  • Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering
  • Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair

Readership

Tissue engineers and developmental biology researchers, post-docs and grad students; clinicians in the field of orthopaedics and tissue transplantation

Table of Contents

  1. Developmental biology of musculoskeletal tissues for Tissue Engineers
    2. The Mechanics of Musculoskeletal Development
    3. Developmental and orthopaedic diseases
    4. Synovial joint development
    5. Articular and Growth plate Cartilage development
    6. Bone development
    7. Disc development
    8. Tendon development
    9. Biomimetic tissue engineering based on human development
    10. Clinical translation

Details

No. of pages:
300
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128114674

About the Editor

Martin J. Stoddart

Principal Scientist, AO Research Institute Davos, Stem Cell Focus Area Leader, Musculoskeletal Regeneration Program

Affiliations and Expertise

Assistant Professor of Orthopaedic Surgery, Boston Children’s Hospital, Harvard Medical School; Principal Faculty, Harvard Stem Cell Institute

April M. Craft

Assistant Professor of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Principal Faculty Member of the Harvard Stem Cell Institute

Affiliations and Expertise

Assistant Professor of Orthopaedic Surgery, Boston Children’s Hospital, Harvard Medical School; Principal Faculty, Harvard Stem Cell Institute

Girish Pattappa

Co-Chair, TERMIS 2015 workshop, “The Tissue Engineering-Developmental Biology Paradigm – A Tool for Developing Successful Therapies”

Affiliations and Expertise

Postdoctoral Research Scientist, Laboratory for Experimental Trauma Surgery, Department of Trauma Surgery, Regensburg University Medical Center, Regensburg, Germany

Oliver F.W. Gardner

Co-Chair, TERMIS 2015 workshop, “The Tissue Engineering-Developmental Biology Paradigm – A Tool for Developing Successful Therapies”

Affiliations and Expertise

Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School and Harvard Department of Stem Cell and Regenerative Biology, Harvard University, Boston, MA, USA

Ratings and Reviews