Developmental Aspects of the Cell Cycle - 1st Edition - ISBN: 9780121569600, 9780323152099

Developmental Aspects of the Cell Cycle

1st Edition

Editors: Ivan Cameron
eBook ISBN: 9780323152099
Imprint: Academic Press
Published Date: 1st January 1971
Page Count: 400
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Developmental Aspects of the Cell Cycle discusses the molecular, organelle, cellular, and organismal levels of cell cycle, cell proliferation, and cell differentiation. It addresses the possible antagonism between the ability of cells to proliferate and to differentiate. After brief historical, theoretical, and methodological background information for each cell system, this book concentrates on the mechanisms involved in the regulation of cell proliferation and differentiation. The book presents systems in which mass cultures of cells can be induced to undergo a synchronous transition from one cell state to another, enabling the amplification of cellular and biochemical events to be analyzed with the available morphological and biochemical techniques. Some chapters explain the possibility of cell state production by a microenvironment that occurs at the organismal level, in which a series of mitotic and growth steps causes cells proliferation. The concluding chapters discuss cell proliferation and differentiation in specific cell system, such as embryonic chick and male germ cell. This book will appeal to investigators in many disciplines, teachers, and life sciences students, particularly, to molecular, cellular, and developmental biologists.

Table of Contents

List of Contributors


1. The Cell Cycle and Cell Differentiation in Trypanosomatids

I. Introduction

II. Life Cycles and Cell Differentiation

III. Cell Cycles and Differentiation


2. Characteristics of Macronuclear RNA in the Cell Cycle of Synchronized Tetrahymena

I. Introduction

II. Nucleocytoplasmic Interactions

III. Stomatogenesis and Polyribosomal Assembly

IV. Nucleic Acid Synthesis

V. Summary and Concluding Remarks


3. Cell Transformation Studies on the Amoeba-Flagellate, Naegleria gruberi

I. Introduction

II. Historical Aspects

III. Modern Studies

IV. Concluding Remarks


4. Temporal Patterns in the Ciliated Protozoa

I. The Nature of Temporal Events

II. Maturity Patterns in Tetrahymena

III. Mechanisms of Temporal Control

IV. Concluding Remarks


5. Mitosis and Differentiation in Hydra Morphogenesis

I. Introduction

II. Structural Aspects

III. Selection of Experimental Hydra

IV. Techniques for Analyzing Mitosis in Hydra

V. Effects of Mitotic Inhibitors on Regeneration and Morphogenesis

VI. Concluding Remarks


6. Radiation Responses during the Mitotic Cycle of the Sea Urchin Egg

I. Introduction

II. General Effects of Irradiating Gametes or Zygotes

III. Effects on Sperm

IV. Effects on Unfertilized Eggs

V. Cyclical Changes

VI. Questions Concerning Targets

VII. General Conclusions and Considerations for the Future


7. Cell Division and Transcription in Developing Frog Embryos

I. Relation of Cell Division to Differentiation

II. RNA Synthesis in Developing Frog Embryos

III. Relation of Transcription to Time of DNA Replication

IV. Effect of Rate and Number of Divisions on Transcription

V. Summary


8. Relationship between Cell Proliferation and Cytodifferentiation in Embryonic Chick Tissues

I. Introduction

II. Review of Individual Developing Systems

III. Discussions and Conclusions


9. Studies on Cellular Proliferation and Chondrogenesis

I. Introduction

II. Cell Cycle and Chondrogenesis

III. Discussion

IV. Summary


10. Differentiation of the Male Germ Cell

I. Introduction

II. The Cycle of the Seminiferous Epithelium

III. Gametogenesis

IV. Final Stages of Spermatozoan Differentiation—The Female Reproductive Tract


11. Immunoglobulin Production in Proliferating Lymphoid Cells

I. Introduction

II. Immunoglobulin Synthesis in Relation to Culture Dynamics

III. Immunoglobulin Gene Expression during the Cell Cycle

IV. Discussion

V. Summary


12. Initial Stages of Cellular Differentiation in the Blood-Forming System of the Mouse

I. Introduction

II. Cellular Organization in the Hemopoietic System

III. Regulation of Stem Cell Functions

IV. Summary


13. Hormonal Regulation of Cell Proliferation and Differentiation

I. Introduction

II. Hormonal Regulation of Cell Proliferation

III. Hormone-Dependent Cell Differentiation

IV. Relationship of Proliferation to Differentiation

V. Some Possible Mechanisms in Hormonal Regulation of Gene Expression

VI. Summary


Author Index

Subject Index


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© Academic Press 1971
Academic Press
eBook ISBN:

About the Editor

Ivan Cameron

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