Development of the Nervous System

3rd Edition

Authors: Dan Sanes Thomas Reh William Harris Dan Sanes Thomas Reh William Harris
Hardcover ISBN: 9780123745392
eBook ISBN: 9780080923208
Imprint: Academic Press
Published Date: 29th March 2011
Page Count: 360
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Description

Development of the Nervous System presents a broad and basic treatment of the established and evolving principles of neural development as exemplified by key experiments and observations from past and recent times. The text is organized ontogenically. It begins with the emergence of the neural primordium and takes a chapter-by-chapter approach in succeeding events in neural development: patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and developmental plasticity. Finally, in the last chapter, with the construction phase nearing completion, we examine the emergence of behavior.  This new edition reflects the complete modernization of the field that has been achieved through the intensive application of molecular, genetic, and cell biological approaches. It is richly illustrated with color photographs and original drawings. Combined with the clear and concise writing, the illustrations make this a book that is well suited to students approaching this intriguing field for the first time.

Key Features

Features
- Thorough survey of the field of neural development
- Concise but complete, suitable for a one semester course on upper level undergraduate or graduate level
- Focus on fundamental principles of organogenesis in the nervous system
- Integrates information from a variety of model systems, relating them to human nervous system development, including disorders of development
- Systematically develops knowledge from the description of key experiments and results.
- Organized ontologically
- Carefully edited to be presented in one voice
- New edition thoroughly updated and revised to include major new findings
- All figures in full color, updated and revised
- Specific attention on revising the chapter on cognitive and behavioral development to provide a foundation and outlook towards those very fast moving areas
- Instructor website with figure bank and test questions

Benefits
- The only thorough textbook of Developmental Neuroscience on the market
- Carefully structured and edited to map onto the syllabus of most developmental neuroscience courses
- Priced to be affordable for undergraduates even in addition to broader textbooks
- Carefully constructed instructor's website
- Specifically designed to make teaching of complicated subjects easy and fun for instructors and students alike

Readership

Neuroscience and developmental biology researchers, students, and educators -mid to upper level undergraduate bio / pre-med, and graduate and medical schools.

Table of Contents

Dedication

Preface to the Third Edition

Preface to the Second Edition

Preface to the First Edition

1. Neural induction

Development and evolution of neurons

Early embryology of metazoans

Derivation of neural tissue

Interactions with neighboring tissues in making neural tissue

The molecular nature of the neural inducer

Conservation of neural induction

Interactions among the ectodermal cells in controlling neuroblast segregation

Summary

2. Polarity and segmentation

Regional identity of the nervous system

The anterior–posterior axis and hox genes

Hox gene function in the vertebrate nervous system

Signaling molecules that pattern the anterior–posterior axis in vertebrates: heads or tails

Organizing centers in the developing brain

Forebrain development, prosomeres, and pax genes

Dorsal–ventral polarity in the neural tube

Dorsal neural tube and neural crest

Patterning the cerebral cortex

Summary

3. Genesis and migration

What determines the number of cells produced by the progenitors?

The generation of neurons and glia

Cerebral cortex histogenesis

Cerebellar cortex histogenesis

Molecular mechanisms of neuronal migration

Postembryonic and adult neurogenesis

Summary

4. Determination and differentiation

Transcriptional hierarchies in invariant lineages: C. elegans neurons

Spatial and temporal coordinates of determination: drosophila CNS neuroblasts

Asymmetric cell divisions and asymmetric fate

Generating complexity through cellular interactions: the drosophila retina

Specification and differentiation through cellular interactions and interactions with the local environment: the vertebrate neural crest

Competence and histogenesis: the mammalian cortex

The interplay of intrinsic and extrin

Details

No. of pages:
360
Language:
English
Copyright:
© Academic Press 2012
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780123745392
eBook ISBN:
9780080923208

About the Author

Dan Sanes

Dr. Sanes is Professor in the Center for Neural Science and Department of Biology at New York University. Named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010 for his research in auditory central nervous system development, his research has been supported by the National Institute on Deafness and Other Communication Disorders and the National Science Foundation. His lab studies synaptic plasticity and central auditory processing, and the phenomenon of hearing loss during development.

Affiliations and Expertise

New York University, New York, U.S.A.

Thomas Reh

Dr. Reh is Professor of Biological Structure and Director of the Neurobiology and Behavior Program at the University of Washington. He is currently a member of the Scientific Advisory Board of the Foundation Fighting Blindness, and of a start-up biotechnology company, Acucela. He has received several awards for his work, including the AHFMR and Sloan Scholar awards and has published over 100 journal articles, reviews and books. Funded by numerous N.I.H. and private foundation grants, his lab is focused on the development and repair of the retina, with an overall goal of understanding the cellular and molecular biology of regeneration in the eye.

Affiliations and Expertise

University of Washington, Seattle, U.S.A.

William Harris

Dr. Harris is co-chair of Cambridge Neuroscience and Director of Studies in Neuroscience. He is also Head of the Department of Physiology, Development, and Neuroscience, and is Professor of Anatomy. Elected a Fellow of the Royal Society of London in 2007, he was Professor of Biology at UCSD prior to accepting a position at Cambridge. His lab is working to elucidate the cellular and molecular events that are used to push or induce cells to transition from proliferating stem cells to differentiated neurons and glia, and how particular regions of the nervous system produce the right number of neurons and the right proportions of different neuron subtypes.

Affiliations and Expertise

University of Cambridge, U.K.

Dan Sanes

Dr. Sanes is Professor in the Center for Neural Science and Department of Biology at New York University. Named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010 for his research in auditory central nervous system development, his research has been supported by the National Institute on Deafness and Other Communication Disorders and the National Science Foundation. His lab studies synaptic plasticity and central auditory processing, and the phenomenon of hearing loss during development.

Affiliations and Expertise

New York University, New York, U.S.A.

Thomas Reh

Dr. Reh is Professor of Biological Structure and Director of the Neurobiology and Behavior Program at the University of Washington. He is currently a member of the Scientific Advisory Board of the Foundation Fighting Blindness, and of a start-up biotechnology company, Acucela. He has received several awards for his work, including the AHFMR and Sloan Scholar awards and has published over 100 journal articles, reviews and books. Funded by numerous N.I.H. and private foundation grants, his lab is focused on the development and repair of the retina, with an overall goal of understanding the cellular and molecular biology of regeneration in the eye.

Affiliations and Expertise

University of Washington, Seattle, U.S.A.

William Harris

Dr. Harris is co-chair of Cambridge Neuroscience and Director of Studies in Neuroscience. He is also Head of the Department of Physiology, Development, and Neuroscience, and is Professor of Anatomy. Elected a Fellow of the Royal Society of London in 2007, he was Professor of Biology at UCSD prior to accepting a position at Cambridge. His lab is working to elucidate the cellular and molecular events that are used to push or induce cells to transition from proliferating stem cells to differentiated neurons and glia, and how particular regions of the nervous system produce the right number of neurons and the right proportions of different neuron subtypes.

Affiliations and Expertise

University of Cambridge, U.K.