Development of T Cell Immunity, Volume 92

1st Edition

Print ISBN: 9780123812841
eBook ISBN: 9780123812858
Imprint: Academic Press
Published Date: 13th September 2010
Page Count: 342
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T cells belong to a group of white blood cells called lymphocytes and play a large role in the immune response. An increased understanding of T cell immunity will provide new insights into the etiology of human autoimmune disease such as diabetes.

This volume reviews the latest developments and discusses the evolution of T cell immunity, thymic requirements, and how to prevent T cell-dependent autoimmunity.

Key Features

Discusses new discoveries, approaches, and ideas in T cell immunity
Contributions from leading scholars and industry experts
* Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in immunology, biochemistry, molecular biology, biotechnology, and medicine.

Table of Contents

Development of T cell immunity

  1. The development of T cell immunity – Adrian Liston
  2. The evolution of T cell immunity

  3. Genome duplication and T cell immunity – Masanori Kasahara

  • Questions arising from "Genome duplication and T cell immunity" – Claude Perreault
  • Response to questions – Masanori Kasahara

  1. The origin and role of MHC class I-associated self peptides – Claude Perreault

  • Questions arising from "The origin and role of MHC class I-associated self peptides" – Masanori Kasahara
  • Response to questions – Claude Perreault

Thymic requirements for T cell immunity

  1. Transcriptional regulation of thymus organogensis and thymic epithelial cell differentiation – Nancy Manley and Brian Condie
  2. Early T cell differentiation: lessons from T-cell acute lymphoblastic leukemia – Cedric S Tremblay, Thu Hoang and Trang Hoang
  3. T cell immunity in the periphery

  4. Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses – Peter J L Lane, Fiona M McConnell, David Withers, Fabrina Gaspal, Manoj Saini and Graham Anderson

  • Commentary on "Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses" – Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes

  1. Cellular and Molecular Requirements in Lymph Node and Peyer’s Patch Development – Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes
  2. T follicular helper cells during Immunity and Tolerance – Michelle A. Linterman and Carola G. Vinuesa
  3. Preventing T cell-dependent autoimmunity

  4. Thymic selecti


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"Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal