COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Development of T Cell Immunity - 1st Edition - ISBN: 9780123812841, 9780123812858

Development of T Cell Immunity, Volume 92

1st Edition

0.0 star rating Write a review
Serial Volume Editor: Adrian Liston
Hardcover ISBN: 9780123812841
eBook ISBN: 9780123812858
Imprint: Academic Press
Published Date: 13th September 2010
Page Count: 342
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

Development of T cell immunity

  1. The development of T cell immunity – Adrian Liston
  2. The evolution of T cell immunity

  3. Genome duplication and T cell immunity – Masanori Kasahara

  • Questions arising from "Genome duplication and T cell immunity" – Claude Perreault
  • Response to questions – Masanori Kasahara

  1. The origin and role of MHC class I-associated self peptides – Claude Perreault

  • Questions arising from "The origin and role of MHC class I-associated self peptides" – Masanori Kasahara
  • Response to questions – Claude Perreault

Thymic requirements for T cell immunity

  1. Transcriptional regulation of thymus organogensis and thymic epithelial cell differentiation – Nancy Manley and Brian Condie
  2. Early T cell differentiation: lessons from T-cell acute lymphoblastic leukemia – Cedric S Tremblay, Thu Hoang and Trang Hoang
  3. T cell immunity in the periphery

  4. Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses – Peter J L Lane, Fiona M McConnell, David Withers, Fabrina Gaspal, Manoj Saini and Graham Anderson

  • Commentary on "Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses" – Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes

  1. Cellular and Molecular Requirements in Lymph Node and Peyer’s Patch Development – Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes
  2. T follicular helper cells during Immunity and Tolerance – Michelle A. Linterman and Carola G. Vinuesa
  3. Preventing T cell-dependent autoimmunity

  4. Thymic selection and lineage commitment of CD4+Foxp3+ regulatory T cells – Paola Romagnoli and Joost P.M. van Meerwijk
  5. Molecular Mechanisms of Regulatory T cell Development and Suppressive Function – Jeong M. Kim

    • Is Foxp3 the master regulator of regulatory T cells? – Adrian Liston


T cells belong to a group of white blood cells called lymphocytes and play a large role in the immune response. An increased understanding of T cell immunity will provide new insights into the etiology of human autoimmune disease such as diabetes.

This volume reviews the latest developments and discusses the evolution of T cell immunity, thymic requirements, and how to prevent T cell-dependent autoimmunity.

Key Features

  • Discusses new discoveries, approaches, and ideas in T cell immunity
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in immunology, biochemistry, molecular biology, biotechnology, and medicine.


No. of pages:
© Academic Press 2010
13th September 2010
Academic Press
Hardcover ISBN:
eBook ISBN:


"Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal

Ratings and Reviews

About the Serial Volume Editor

Adrian Liston

Adrian Liston

Adrian Liston is Professor in Autoimmune Genetics at the University of Leuven and the VIB, Belgium. His PhD research was on T cell tolerance and diabetes with Professor Chris Goodnow at the Australian National University, followed by post-doctoral research on regulatory T cell biology with Professor Sasha Rudensky at the University of Washington. The Liston laboratory is supported by an ERC Start Grant, a JDRF Career Development Award, a VIB Investigators Award and grants from the FWO and KUL. Adrian Liston has published more than 70 papers, with over 3000 citations, including key publications on the function of Aire in thymic tolerance, defective tolerance in the NOD mouse, the contribution of immunodeficiency to autoimmunity, microRNA function in regulatory T cells, the discovery of the follicular regulatory T cell, the role of microRNA in the thymic epithelium and the homeostatic control over regulatory T cells.

Affiliations and Expertise

Katholieke Universiteit Leuven, Belgium