Development of Anti-Asthma Drugs

Development of Anti-Asthma Drugs

1st Edition - October 2, 1984

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  • Authors: Derek R. Buckle, Harry Smith
  • eBook ISBN: 9781483192475

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Description

Development of Anti-Asthma Drugs reviews existing asthma treatments and novel approaches currently under investigation, in the context of their mode of action and clinical effectiveness, in the hope that this might lead to a greater understanding of the factors involved in the expression of the disease and, therefore, in the design of better drugs. It is planned based on the concept of the causes and treatment of asthma, This book is organized in three main parts. Part I deals with the nature of asthma, its pathological mechanisms, natural history and epidemiology. Part II discusses mediators associated with asthma including platelet-activating factor, leukotrienes and histamine. Part II covers pharmaceutical approaches in the development of anti-asthma drugs and includes sections on inhibitors of mediator release and competitive and functional antagonists. This book will be of interest to persons dealing with studies on anti-asthma drugs and those interested in pharmacological development.

Table of Contents


  • Contents

    Introduction

    Part 1 Asthma—The Nature of the Disease

    1 Asthma—The Nature of the Disease

    Definition—What Is Asthma?

    Natural History

    Epidemiology

    Pathological Mechanisms

    Part 2 Mediators

    2 Histamine

    Introduction

    Histamine Release

    Actions of Histamine

    Concluding Remarks

    3 Leukotrienes

    Introduction

    Structure, Formation and Metabolism

    Biological Activities of the Leukotrienes

    Conclusions

    4 Platelet-Activating Factor

    Introduction

    Historical Overview of Platelet-Activating Factor

    Structure and Metabolism of PAF

    PAF Production In Inflammation

    PAF-Induced Platelet Stimulation

    Other Inflammatory Effects of PAF

    Physiology

    Effects On Smooth Muscle

    Effects of Vascular Permeability

    Pharmacological Modulation

    Conclusion

    5 Eosinophils and Neutrophils

    Introduction

    General Properties of Eosinophils and Neutrophils

    Allergy and the Eosinophil

    Allergy and the Neutrophil

    Inflammatory Cells and the Progression of Asthma

    Corticosteroids, Eosinophils and Neutrophils

    Summary

    6 Acetylcholine Laurie

    Introduction

    Acetylcholine As A Neurotransmitter

    The Cholinergic Nervous System In Asthma

    Summary

    Part 3 Pharmacological Approaches

    Section 1 Competitive Antagonists

    7 Hi Antihistamines

    8 SRS-A Antagonists

    9 Anti-Cholinergic Drugs

    Section 2 Functional Antagonists

    10 Drugs Acting At Adrenoceptors

    11 Theophylline

    12 Prostaglandins and Related Compounds

    Section 3 Inhibitors of Mediator Release

    13 Disodium Cromoglycate and Compounds With Similar Activities

    14 Corticosteroids

    15 Non-Steroidal Inhibitors of Arachidonic Acid Metabolism

    16 Specific Hyposensitization

    Summary

    Index


Product details

  • No. of pages: 416
  • Language: English
  • Copyright: © Butterworth-Heinemann 1984
  • Published: October 2, 1984
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483192475

About the Authors

Derek R. Buckle

Harry Smith

Affiliations and Expertise

Paediatric Haematologist, Department of Pathology, Royal Brisbane hospital; Clinical Professor in Child Health, University of Queensland

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