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Development of Anti-Asthma Drugs reviews existing asthma treatments and novel approaches currently under investigation, in the context of their mode of action and clinical effectiveness, in the hope that this might lead to a greater understanding of the factors involved in the expression of the disease and, therefore, in the design of better drugs. It is planned based on the concept of the causes and treatment of asthma, This book is organized in three main parts. Part I deals with the nature of asthma, its pathological mechanisms, natural history and epidemiology. Part II discusses mediators associated with asthma including platelet-activating factor, leukotrienes and histamine. Part II covers pharmaceutical approaches in the development of anti-asthma drugs and includes sections on inhibitors of mediator release and competitive and functional antagonists. This book will be of interest to persons dealing with studies on anti-asthma drugs and those interested in pharmacological development.
Part 1 Asthma—The Nature of the Disease
1 Asthma—The Nature of the Disease
Definition—What Is Asthma?
Part 2 Mediators
Actions of Histamine
Structure, Formation and Metabolism
Biological Activities of the Leukotrienes
4 Platelet-Activating Factor
Historical Overview of Platelet-Activating Factor
Structure and Metabolism of PAF
PAF Production In Inflammation
PAF-Induced Platelet Stimulation
Other Inflammatory Effects of PAF
Effects On Smooth Muscle
Effects of Vascular Permeability
5 Eosinophils and Neutrophils
General Properties of Eosinophils and Neutrophils
Allergy and the Eosinophil
Allergy and the Neutrophil
Inflammatory Cells and the Progression of Asthma
Corticosteroids, Eosinophils and Neutrophils
6 Acetylcholine Laurie
Acetylcholine As A Neurotransmitter
The Cholinergic Nervous System In Asthma
Part 3 Pharmacological Approaches
Section 1 Competitive Antagonists
7 Hi Antihistamines
8 SRS-A Antagonists
9 Anti-Cholinergic Drugs
Section 2 Functional Antagonists
10 Drugs Acting At Adrenoceptors
12 Prostaglandins and Related Compounds
Section 3 Inhibitors of Mediator Release
13 Disodium Cromoglycate and Compounds With Similar Activities
15 Non-Steroidal Inhibitors of Arachidonic Acid Metabolism
16 Specific Hyposensitization
- No. of pages:
- © Butterworth-Heinemann 1984
- 2nd October 1984
- eBook ISBN:
Paediatric Haematologist, Department of Pathology, Royal Brisbane hospital; Clinical Professor in Child Health, University of Queensland
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