Development And Growth

Development And Growth

2nd Edition - January 28, 1972

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  • Editor: Geoffrey Bourne
  • eBook ISBN: 9780323161503

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The Biochemistry and Physiology of Bone, Second Edition: Volume III: Development and Growth focuses on bone development and growth, including bone repair and transplantation, the mechanisms of bone formation, and the role of hormones in bone formation and maintenance. It also explores osteogenesis in the human embryo and fetus, the internal remodeling and growth of bones, bone turnover and osteoporosis, cellular dynamics of bone, and the effects of radiation on bone. Organized into 12 chapters, this edition begins with an overview of the biophysical principles affecting bone structure, with emphasis on the direct and indirect effects of pressure on cells and the possible mechanisms by which cell behavior is controlled by bioelectrical responses. It then discusses the periosteal and endochondral ossification of cartilage bone, internal remodeling in the young adult skeleton, structural aspects of bone growth, and radioautographic studies of bone formation. It also explains the symptoms, diagnosis, and treatment of osteoporosis; histology of osteocytic resorption; tritiated thymidine studies in bone; induction of heterotopic bone formation; requirements for cell survival in free autologous transplants; and skeletal effects of ovarian steroids. The book concludes with a chapter on the effects of radiation on tissues closely related to bone. Biochemists, cell biologists, physiologists, anatomists, orthopedists, pathologists, clinicians, biomedical engineers, graduate students, professors, and others interested in the bone development and growth will find this book highly informative.

Table of Contents

  • List of Contributors

    Preface to Second Edition

    Preface to First Edition

    Contents of Other Volumes

    Chapter 1. Biophysical Principles Affecting Bone Structure

    I. Introduction

    II. Form and Function

    III. Bioelectrical Effects on Cells and Their By-products

    IV. Possible Mechanisms by Which Bioelectrical Responses Control Cell Behavior

    V. Summary


    Chapter 2. Osteogenesis in the Human Embryo and Fetus

    I. Introduction

    II. Ossification and Growth

    III. Development of Specific Bones

    IV. Onset and Sequence of Ossification

    V. General Considerations of Bone Development


    Chapter 3. The Internal Remodeling of Bones

    I. Introduction

    II. The Internal Remodeling in the Young Adult Skeleton

    III. The Internal Remodeling in the Growing Skeleton

    IV. The Internal Remodeling in the Aging Skeleton

    V. The Significance of the Internal Remodeling


    Chapter 4. The Growth of Bone

    I. Body Growth and Bone Growth

    II. Structural Aspects of Bone Growth

    III. Physiological Control of Normal Bone Growth

    IV. Bone Growth under Pathological Conditions

    V. Conclusions


    Chapter 5. Radioautographic Studies of Bone Formation

    I. General Introduction

    II. Historical Introduction

    III. The Growing Osteon of Long Bones in Dogs as a Model for the Formation of Bone Tissue

    IV. Biosynthesis of the Organic Bone Matrix—Collagen Formation

    V. Biosynthesis of the Organic Bone Matrix—Mucopolysaccharide and Glycoprotein Formation

    VI. Acquisition of Minerals by Bone Tissues

    VII. Conclusions


    Chapter 6. Bone Turnover and Osteoporosis

    I. Introduction

    II. Osteopenias Associated with Known Abnormalities

    III. Bone Turnover

    IV. The Osteoporotic Patient

    V. Osteoporosis and Osteomalacia

    VI. Osteoporosis and Secondary and "Primary" Hyperparathyroidism

    VII. Treatment of Osteoporosis


    Chapter 7. Osteocytic Resorption

    I. Introduction

    II. Historical Review

    III. Technical Approaches

    IV. Cementolysis

    V. The Place of Osteolysis in Bone Physiology

    VI. Objection

    VII. Enlarged Lacunae without Osteolysis

    VIII. Osteocytic Resorption among Vertebrates

    IX. Factors Which Promote Osteocytic Resorption

    X. Adverse Factors

    XI. Osteocytic Resorption in Human and Animal Pathology


    Chapter 8. Cellular Dynamics of Bone

    I. Introduction

    II. Compartments of Bone Cells

    III. Bone Surfaces

    IV. Cellular Nomenclature

    V. Cell Kinetics

    VI. Tritiated Thymidine Studies in Bone

    VII. The Effect of Different Agents on Cellular Dynamics

    VIII. Other Studies

    IX. Concluding Remarks


    Chapter 9. Induction of Heterotopic Bone Formation

    I. Introduction

    II. Description of the Existing Experimental Systems

    III. The Nature of the Inductive Agent

    IV. Transplantological Problems

    V. Conclusions


    Chapter 10. Repair and Transplantation of Bone

    Part 1. The Repair of Bone

    I. Introduction

    II. The General Features of a Bone and the Location of the Various Members of the Bone Cell Lineage in Its Substance and on Its Surfaces

    III. The Morphology and Behavior following a Fracture of the Members of the Bone Cell Lineage

    IV. Fracture Healing in Man

    Part 2. The Transplantation of Bone

    I. Introduction

    II. The Requirements for Cell Survival in Free Autologous Transplants

    III. Transplants of Autologous Compact Bone

    IV. Transplants of Homologous Compact Bone

    V. Transplants of Autologous Cancellous Bone

    VI. Transplants of Homologous Cancellous Bone

    VII. The Types of Grafts Used in Some Common Clinical Conditions

    VIII. Studies on the Transplantation of Epiphyseal Plates


    Chapter 11. Steroid Hormones and Bone

    I. Introduction

    II. Scope of the Problem

    III. Sexual Dimorphism of the Skeleton

    IV. Ovarian Steroids

    V. Testicular Steroids

    VI. Anabolic Steroids with Minimal or No Androgenic Activity

    VII. Adrenal Cortical Steroids

    VIII. Summary and Conclusions


    Chapter 12. The Effects of Radiation on Bone

    I. Introduction

    II. Tissues Associated with Skeleton at Risk from Radiation

    III. Radiation Dosimetry

    IV. Characteristics of the Important Bone-Seeking Radionuclides

    V. External Radiation

    VI. Internal Radiation

    VII. Conclusions


    Author Index

    Subject Index

Product details

  • No. of pages: 604
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 28, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9780323161503

About the Editor

Geoffrey Bourne

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