Development and Function of Myeloid Subsets, Volume 120

1st Edition

Serial Volume Editors: Kenneth Murphy Miriam Merad
Hardcover ISBN: 9780124170285
eBook ISBN: 9780124171176
Imprint: Academic Press
Published Date: 1st October 2013
Page Count: 318
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Table of Contents

Series Page


Chapter One. Ontogeny and Functional Specialization of Dendritic Cells in Human and Mouse


1 Introduction

2 History of DC Identification and Characterization

3 Recent Advances in Mouse DC Immunobiology: Lessons from a Rodent

4 Recent Advances in Human DC Immunobiology

5 Humanized Mice

6 Matching Mice and Men

7 The Relationship of DCs to Monocytes and Macrophages

8 Next Steps Ahead

9 Disclosure Statement



Chapter Two. Dendritic Cell Migration Through the Lymphatic Vasculature to Lymph Nodes


1 Structure and Function of the Lymphatic Vasculature

2 DC Migration into Lymphatics and the Requirement for Specialized Lymphatic Capillaries

3 DC Mobilization to LNs: The Role of CCR7

4 DC Mobilization to LNs: The Machinery for Locomotion

5 Lymphangiogenesis and DC Trafficking During Inflammation

6 Concluding Remarks


Chapter Three. A Close Encounter of the Third Kind: Monocyte-Derived Cells


1 Dendritic Cell and Macrophages

2 Monocytes, the Mononuclear Phagocytes of the Blood Compartment

3 Monocytes, as Precursors of Tissue Mononuclear Phagocytes

4 Monocyte-Derived Cells in the Inflamed Peritoneum

5 Monocyte-Derived Cells in the Inflamed Brain

6 Monocyte-Derived Cells in the Intestine

7 Development of Monocyte-Derived Cells

8 Perspective



Chapter Four. Plasmacytoid Dendritic Cell Development


1 Background

2 Markers for pDC Identification

3 Cytokines Promoting pDC Development

4 Transcription Factors Determining pDC Development

5 Early Investigation of the Myeloid Versus Lymphoid Origin of pDC

6 Markers of pDC of Lymphoid


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Informs and updates on all the latest developments in the field
  • Contributions from leading authorities and industry experts


Immunologists and infectious disease specialists, cell biologists and hematologists.


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© Academic Press 2013
Academic Press
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"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

About the Serial Volume Editors

Kenneth Murphy Serial Volume Editor

Affiliations and Expertise

Washington University School of Medecine, USA

Miriam Merad Serial Volume Editor

Affiliations and Expertise

Icahn Medical Institute, New York, USA