Determinants of Neuronal Identity

Determinants of Neuronal Identity

1st Edition - January 1, 1992

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  • Editor: Marty Shankland
  • eBook ISBN: 9780323141543

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Determinants of Neuronal Identity brings together studies of a wide range of vertebrate and invertebrate organisms that highlight the determinants of neuronal identity. Emphasis of this book is on how neurons are generated; how their developmental identities are specified; and to what degree those identities can be subsequently modified to meet the changing needs of the organism. This book also considers various techniques used in the analysis of different organisms. This volume is comprised of 15 chapters; the first of which introduces the reader to the specification of neuronal identity in Caenorhabditis elegans. The discussion then turns to neurogenesis and segmental homology in the leech, as well as intrinsic and extrinsic factors influencing the development of Retzius neurons in the leech nervous system. Drosophila is discussed next, with particular reference to neuronal diversity in the embryonic central nervous system, cell choice and patterning in the retina, and development of the peripheral nervous system. Other chapters explore endocrine influences on the postembryonic fates of neurons during insect metamorphosis; neuron determination in the nervous system of Hydra and in the mammalian cerebral cortex; and segregation of cell lineage in the vertebrate neural crest. This book will help scientists and active researchers in synthesizing a conceptual framework for further studies of neuronal specification.

Table of Contents

  • Contributors


    1 Specification of Neuronal Identity in Caenorhabditis elegans

    I. Introduction

    II. Early Neurogenesis

    III. Cell Type Specification and Differentiation (Late Neurogenesis)

    IV. Prospects


    2 Segmental Differentiation of Lineally Homologous Neurons in the Central Nervous System of the Leech

    I. Introduction

    II. Leech Neuroanatomy

    III. Neurogenesis and Segmental Homology

    IV. Determination of Neuronal Phenotype by Cell Lineage History

    V. Determination of Neuronal Phenotype by Postmitotic Cell Interactions

    VI. Spatial Patterning of Neuronal Differentiation


    3 Control of Central Neurogenesis in the Leech

    I. Introduction

    II. Early Neurogenesis in the Leech

    III. Significant Segmental Differences in Cell Number in the Ventral Nerve Cord

    IV. Birth of Extra Neurons in the Sex Ganglia Depends on Their Innervation of the Male Genitalia

    V. What are the Precursors of the Peripherally Induced Central Neurons?

    VI. What is the Nature of the Mitogenic Signal?


    4 Intrinsic and Extrinsic Factors Influencing the Development of Retzius Neurons in the Leech Nervous System

    I. Introduction

    II. Adult Properties of Retzius Neurons

    III. Influences of Intrinsic Properties and Early Interactions

    IV. Later Peripheral Interactions

    V. Summary


    5 The Generation of Neuronal Diversity in the Drosophila Embryonic Central Nervous System

    I. Neuroblast Formation

    II. Generation of Neuronal Diversity

    III. Gene Regulatory Hierarchies in the Central Nervous System

    IV. Perspectives


    6 Initial Determination of the Neuroectoderm in Drosophila

    I. Introduction

    II. The Neural-Epidermal Decision

    III. Genetic Mechanisms in the Neural-Epidermal Decision: Controlling Gene Expression

    IV. Genetic Mechanisms in the Neural-Epidermal Decision: Genes Taking Part in Interactions between Cells

    V. The Neural-Epidermal Decision: Tilting the Balance and Keeping it Tilted

    VI. Conclusion


    7 Cell Choice and Patterning in the Drosophila Retina

    I. Introduction

    II. Structure of the Compound Eye

    III. Description of Eye Development

    IV. Developmental Analysis of the Retina

    V. The Role of Specific Genes in Regulating Eye Development

    VI. Perspective


    8 Development of the Peripheral Nervous System in Drosophila

    I. Introduction

    II. A Progressive Process

    III. Acquisition of Competence

    IV. Singling out the Sensory Mother Cell

    V. Differentiating the Sensory Mother Cell

    VI. Differentiating the Neuron

    VII. Programming Diversity

    Appendix: Genetic Methods and Tools


    9 Endocrine Influences on the Postembryonic Fates of Identified Neurons During Insect Metamorphosis

    I. Introduction

    II. Description of the Life Cycle and Hormones of Manduca

    III. Metamorphic Fates of Identified Neurons

    IV. Conclusions


    10 Neuron Determination in the Ever-Changing Nervous System of Hydra

    I. Introduction

    II. The Nervous System of Hydra

    III. The Nerve Net is Dynamic

    IV. Neuron Cell Lineages

    V. Commitment of Multipotent Stem Cells to Neuronal Differentiation

    VI. Neuronal Phenotype is Position-Dependent

    VII. Basis of Position-Dependent Conversion

    VIII. Summary


    11 Cell Lineage Segregation in the Vertebrate Neural Crest

    I. Introduction

    II. Developmental Potential of Neural Crest Cell Populations

    III. Evidence That Individual Neural Crest Cells are Multipotent

    IV. Evidence for Subpopulations at Stages of Neural Crest Cell Migration

    V. Evidence for Neural Crest Sublineages at Postmigratory Stages

    VI. Role of Growth Factors in Neural Crest Cell Differentiation

    VII. Phenotypic Plasticity in Neural-Crest-Derived Ganglia

    VIII. Conclusions Regarding Mechanism s of Cell-Type Segregation in the Neural Crest


    12 The Determination of Neuronal Identity in the Mammalian Cerebral Cortex

    I. Introduction

    II. Organization and Development of the Mammalian Cerebral Cortex

    III. Mechanisms of Neuronal Determination

    IV. Axon Outgrowth in the Developing Cerebral Cortex

    V. Summary


    13 Generation of Neuronal Diversity in the Vertebrate Retina

    I. Introduction

    II. The Embryology of the Eye

    III. Sensory Retinal Histogenesis

    IV. Mechanisms of Cell Determination in the Sensory Retina

    V. Conclusions


    14 Development of Motoneuronal Identity in the Zebrafish

    I. Introduction

    II. Early Patterning of the Embryo

    III. Differentiation of the Nervous System

    IV. Criteria for Identification of Primary Motoneurons

    V. Development of Primary Motoneuronal Identity

    VI. Conclusions


    15 Cellular and Molecular Mechanisms Determining Neurotransmitter Phenotypes in Sympathetic Neurons

    I. Introduction

    II. Neurotransmitter Phenotypes of Sympathetic Neurons

    III. A System for Studying Cholinergic Sympathetic Neurons: Sweat Gland Innervation

    IV. Developmental History of Sympathetic Neurons

    V. Molecules That Specify Neurotransmitter Phenotype

    VI. Transient Catecholaminergic Cells of the Gut also Change Their Phenotype

    VII. Effects of the Alteration in Transmitter Properties on Target Function

    VIII. Summary and Conclusions



Product details

  • No. of pages: 544
  • Language: English
  • Copyright: © Academic Press 1992
  • Published: January 1, 1992
  • Imprint: Academic Press
  • eBook ISBN: 9780323141543

About the Editor

Marty Shankland

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