Detection of Drugs and Their Metabolites in Oral Fluid - 1st Edition - ISBN: 9780128145951

Detection of Drugs and Their Metabolites in Oral Fluid

1st Edition

Authors: Robert White Christine Moore
Paperback ISBN: 9780128145951
Imprint: Elsevier
Published Date: 23rd February 2018
Page Count: 150
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Table of Contents

  1. Introduction
    2. Collection of Oral Fluid
    3. Point of Collection Testing
    4. Initial Testing (Laboratory-Based)
    5. Specimen Validity Testing
    6. Confirmatory Testing
    7. Proficiency Testing
    8. Specific Analytes
    9. Concluding Remarks


Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. Drs. Robert M. White and Christine Moore summarize the state of the science, including its strengths, weaknesses, unmet methodological needs and cutting-edge trends. This volume covers all aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Specific analytes include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics and miscellaneous drugs.

This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of saliva as a test medium, and finally to a consideration of detection methods and their validation and employment.

Key Features

  • Compares different collection and testing systems to assist readers involved in clinical or forensic practice in selecting oral fluid as the matrix of choice
  • Provides a sound basis for the detection of drugs and their metabolites in oral fluid and the interpretation of both positive and negative
  • Places the need, or lack thereof, for specimen validity testing and confirmation testing in context with the purposes of oral fluid testing
  • Describes drugs and drug classes that can be tested, along with useful information on a patient/donor’s drug status


Analytical chemists, pharmacologists, medical practitioners involved in drug treatment, addictionologists, clinical trials specialists, regulatory scientists and administrators, public health officials, forensic scientists, toxicologists, and law enforcement


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About the Authors

Robert White Author

Dr. Robert M. White, Sr., is a Senior Forensic Scientist at the Center for Forensic Sciences, RTI International, Research Triangle Park, NC, USA. He has extensive experience in risk assessment, legal consulting, and federal inspections. Dr. White also has experience with conducting law enforcement, clinical drug, and anonymous waiver (U.S. Drug Enforcement Agency [DEA]) testing.

Affiliations and Expertise

Center for Forensic Sciences, RTI International, Research Triangle Park, NC, USA

Christine Moore Author

Dr. Christine M. Moore is the Vice President of Toxicology Research and Development for Immunalysis Corporation, a company specializing in the development, manufacture and distribution of immunoassay systems for testing drugs of abuse in various biological matrices. She is the Director of the laboratory where the National Roadside Survey biological specimens were analyzed for the 2005 pilot study and for the 2007 expanded project. Dr. Moore has a Bachelor of Science (Honors) degree in Applied Chemistry from the University of Salford, England (1985), a Master of Science degree in Forensic Science from the University of Strathclyde, Scotland (1986), and a Ph.D. in Forensic Toxicology from the University of Glasgow, Scotland (1989). She is Board Certified in Toxicological Chemistry by the American Board of Clinical Chemistry (DABCC), and is a Fellow of the Royal Society of Chemistry and the American Academy of Forensic Sciences. Christine is currently the President of the Society of Forensic Toxicologists (SOFT) and Vice-President of the Society of Hair Testing. She is a member of the International Association of Toxicologists (TIAFT), the American Association of Clinical Chemistry (AACC), the Research Society on Alcoholism (RSA), the California Association of Toxicologists (CAT), and the International Council on Alcohol, Drugs and Traffic Safety (ICADTS), where she is Co-Chair of the Ethanol Biomarker Committee. Additionally, she is Past-President of the Mid-West Association for Toxicology and Therapeutic Drug Monitoring (MATT) and is past Chair of the Toxicology Section of the American Academy of Forensic Sciences. She serves on the Editorial Board of the Journal of Analytical Toxicology and is a reviewer for several other journals. She currently has over 85 peer-reviewed publications regarding the analysis of drugs in biological matrices, including oral fluid, meconium and hair.

Affiliations and Expertise

Immunalysis Corporation, Pomona, CA, USA