Description

This volume, derived from Encyclopedia of Virology, provides an overview of the development of virology during the last ten years.  Entries detail the nature, origin, phylogeny and evolution of viruses. It then moves into a summary of our understanding of the structure and assembly of virus particles and describes how this knowledge was obtained. Genetic material of viruses and the different mechanisms used by viruses to infect and replicate in their host cells are highlighted. The volume is rounded out with an overview of some major groups of viruses with particular attention being given to our current knowledge of their molecular biology.

Key Features

  • The most comprehensive single-volume source providing an overview of virology to non-specialists
  • Bridges the gap between basic undergraduate texts and specialized reviews
  • Concise and general overviews of important topics within the field will help when preparing for lectures, writing reports, or drafting grant applications
  • Readership

    virologists, microbiologists, immunologists, parasitologists working in research, teaching, industry and government

    Table of Contents

    Section 1. GENERAL TOPICS
    History of virology : bacteriophages
    History of virology :  plant viruses
    History of virology : vertebrate viruses
    Nature of viruses
    Origin of viruses
    Ribozymes
    Virus species
    Quasispecies
    Virus databases
    Phylogeny of viruses
    Evolution of viruses
    Taxonomy, classification and nomenclature of viruses
    Virus classification by pairwise sequence comparison
    Prions of vertebrates
    Viruses and bioterrorism

    Section 2. VIRIONS  
    Principles of virion structure
    Structure of non-enveloped virions
    Electron microscopy of viruses
    Cryo-electron microcopy
    Assembly of non-enveloped virions
    Assembly of enveloped virions
    Assembly of bacterial viruses
    Genome packaging of bacterial viruses
    Viral membranes
    Mimivirus

    Section 3. NUCLEIC ACIDS 
    Recombination
    Satellite nucleic acids and viruses
    Retrotransposons of vertebrates
    Defective interfering viruses
    Interfering RNAs
    Viruses as vectors in gene therapy 

    Section 4. VIRUS INFECTION 
    Viral receptors 
    Virus entry to bacterial cells
    Membrane  fusion
    Replication of viruses
    Persistent and latent viral infection
    Apoptosis and virus infection
    Viral pathogenesis
    Antiviral agents
    Diagnosis using serological and molecular approaches
    Diagnosis using microarrays
    Disease surveillance

    Section 5. IMMUNE RESPONSES
    Innate immunity
    Defeating innate immunity
    Antigen presentation
    Antigenicity and immunogenicity  of viral proteins
    Cytokines and chemokines
    Cell-mediated immunity to viruses
    Antibody - mediated immunity to viruses
    Orthomyxovirus antigen structure
    Antigenic variation
    Vaccine strategies
    DNA Vaccines
    Vaccine safety
    Neutralization of infectivity
    Immunopathology

    Section 6. DESCRIPTI

    Details

    No. of pages:
    672
    Language:
    English
    Copyright:
    © 2010
    Published:
    Imprint:
    Academic Press
    eBook ISBN:
    9780123751621
    Print ISBN:
    9780123751461

    About the editors

    Marc van Regenmortel

    Affiliations and Expertise

    ESBS , CNRS , Strasbourg, France

    Brian Mahy

    Affiliations and Expertise

    Coordinating Center for Infectious Diseases, CDC, Atlanta, GA, USA