Chapter 1: Introduction: Strategies on different levels in organic synthesis.
Chapter 2: Experimental study of reaction conditions. Initial remarks.
Chapter 3: Models as tools.
Chapter 4: General outline of screening experiments.
Chapter 5: Two-level factorial designs.
Chapter 6: Two-level fractional factorial designs.
Chapter 7: Other designs for screening experiments.
Chapter 8: Summary of screening experiments.
Chapter 9: Optimisation.
Chapter 10: Steepest ascent.
Chapter 11: Simplex methods.
Chapter 12: Response surface methods.
Chapter 13:Reaction kinetics by sequential response
Chapter 14: Summary of strategies for exploring the
Chapter 15: The reaction space.
Chapter 16: Principal properties.
Chapter 17: Strategies for the selection of test systems.
Chapter 18: Quantitative relations: Observed responses and experimental variations.
Chapter 19: Exploring discrete variations: Near-orthogonal experiments by singular value.
Chapter 20: Optimisation when there are several response variables.
Chapter 21: A method for determining suitable order of introducing reagents in "one-pot" procedures.
Chapter 22: Books, journals, and computer programs.
Chapter 23: Concluding remarks.
Appendix A: Matrix calculus.
Appendix B: Statistical tables.