Dermatopathology, An Issue of Surgical Pathology Clinics

1st Edition, Volume 14-2 - June 4, 2021
Editor: Michael T. Tetzlaff
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 9 3 4 7 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 9 3 4 8 - 3

In this issue of Surgical Pathology Clinics, guest editor Michael T. Tetzlaff brings his considerable expertise to the topic of Dermatopathology. Top experts in the field cover… Read more

Dermatopathology, An Issue of Surgical Pathology Clinics

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In this issue of Surgical Pathology Clinics, guest editor Michael T. Tetzlaff brings his considerable expertise to the topic of Dermatopathology. Top experts in the field cover key topics such as Mucosal Melanoma Molecular, Vasculitis, Nail Pathology, and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
PRAME Immunohistochemistry as an Ancillary Test for the Assessment of Melanocytic Lesions
Background
PRAME immunohistochemistry in primary cutaneous melanoma and nevi
PRAME immunohistochemistry in challenging cutaneous melanocytic tumors
PRAME in the assessment of nodal melanocytic deposits
PRAME immunohistochemistry in conjunctival melanocytic nevi and mucosal melanomas
PRAME immunohistochemistry in other malignant neoplasms
Summary
Gamma/Delta Phenotype in Primary Cutaneous T-cell Lymphomas and Lymphoid Proliferations: Challenges for Diagnosis and Classification
Overview
Primary cutaneous γδ T-cell lymphoma
Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma
Epstein–Barr virus–positive T/natural killer cell lymphomas and lymphoid proliferations
Subcutaneous panniculitis-like T-cell lymphoma
CD30-positive T-cell lymphoproliferative disorders that may show γδ and cytotoxic phenotype
Inflammatory conditions that may display γδ T lymphocytic infiltrates
Summary
Clinics care points
Update on Cutaneous Soft Tissue Tumors
EWSR1-SMAD3-rearranged fibroblastic tumor
Superficial CD34-positive fibroblastic tumor
Epithelioid fibrous histiocytoma
CIC-rearranged sarcoma
NTRK-rearranged spindle cell neoplasm
Cutaneous Toxicities in the Setting of Immune Checkpoint Blockade:: The Era of Oncodermatopathology
Overview
Clinical features
Microscopic features and diagnosis
Differential diagnosis
Prognosis
Immunopathogenesis of cutaneous immune-related adverse events
Summary
Clinics care points
Mucosal Melanomas of the Anogenital Tract: Clinical and Pathologic Predictors of Patient Survival
Overview
Gross features
Microscopic features
Differential diagnosis
Diagnosis
Ancillary studies, diagnostic: immunohistochemistry
Prognosis
Staging
Clinical stage predicts outcome in vulvar and anorectal melanomas
Risk stratification of vulvar and anorectal melanoma presenting with localized disease at diagnosis
Summary
Clinics care points
Connective Tissue Diseases in the Skin: Emerging Concepts and Updates on Molecular and Immune Drivers of Disease
Overview
Cutaneous lupus erythematosus
Dermatomyositis
Scleroderma/systemic sclerosis
Mixed connective tissue disease
Summary
Clinics care points
Update on Molecular Genetic Alterations of Cutaneous Adnexal Neoplasms
Overview of cutaneous neoplasia
Lesions with predominant follicular differentiation
Neoplasms with predominant sweat gland differentiation
Tumors with mixed differentiation
Site-specific neoplasms
Other tumors
Summary
Clinics care points
Molecular Genetics of Sebaceous Neoplasia
Overview
Microscopic features
Molecular pathology features
Diagnosis
Summary
Clinics care points
Pigmented Epithelioid Melanocytoma: Morphology and Molecular Drivers
Overview
Gross features
Microscopic features
Genomic studies
Immunohistochemistry
Differential diagnosis
Prognosis
Epithelioid blue nevus of Carney complex
Summary
Clinics care points
Mucosal Melanoma: A Review Emphasizing the Molecular Landscape and Implications for Diagnosis and Management
Overview
Biology and epidemiology
Clinical features
Microscopic features
Molecular landscape of mucosal melanoma
Current systemic treatment options and the future
Clinics care points
Leukocytoclastic Vasculitis and Microvascular Occlusion: Key Concepts for the Working Pathologist
Overview
Definitions
Background
Relevant clinical Considerations
Discussion: Selected diseases with leukocytoclastic vasculitis or microvascular occlusion
Summary
Clinics care points
Updates on the Pathology and Management of Nail Unit Tumors and Dermatoses
Nail plate histopathology
Onychomatricoma
Onychocytic matricoma/longitudinal subungual acanthoma
Onychopapilloma
Melanocytic nail tumors
Nail unit squamous cell carcinoma
Acral dermatofibrosarcoma protuberans
Glomus tumor
Nail inflammatory disorders: psoriasis, lichen planus, and onychotillomania
Clinics care points
Dysplastic Nevi: Morphology and Molecular and the Controversies In-between
Overview
Historical background
Terminology and synonyms
Dysplastic nevus and melanoma risk
Clinical features
Microscopic features
Histopathologic grading
Immunohistochemistry
Molecular and genetic features
Treatment
Differential diagnoses
Summary
Clinics care points