1st Edition - June 9, 2008

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  • Editors: Charles Duyckaerts, Irene Litvan
  • Hardcover ISBN: 9780444518989
  • eBook ISBN: 9780080559865

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This volume provides a comprehensive understanding of the biology of dementias, including information on advancements in the way these disorders are perceived and studied. From earlier assumptions that cognitive deficits were simply age related, this handbook progresses into complex discussions of the diseases that affect the cortex of the human brain. Clinicians will find extensive diagnostic and research perspectives on a variety of interesting topics, including neuropathology, physiopathology, biology, clinics, and imaging information on all, or most, of the dementing disorders currently known. In addition, chapters devoted to legal and ethical issues give practitioners and health care workers an informative view on complex dementias and the way these disorders affect patients and families. Clinicians in all levels of expertise will find useful and synthetic information.

Key Features

* Comprehensive information on advancements in the study and diagnosis of dementias
* Complex discussions of the diseases that affect the cortex of the human brain
* Extensive diagnostic and research perspectives on topics including, but not limited to, neuropathology, physiopathology, and groundbreaking imaging techniques
* A reference guide that is appropriate for clinicians in all levels of expertise, from researchers to basic health care providers


Neurologists and neuroscience research workers

Table of Contents

  • Section 1: General aspects:

    History of dementia. Neuropsychological examination in dementia. Executive dysfunction and neuropsychological testing. Neuropsychiatric evaluation in dementia. Electrophysiological evaluation of dementia. Feature extraction and strategy of analyzing structural neuroimaging in dementia. Strategies for using molecular neuroimaging in dementia. Quality of life in dementias. Diagnosis and management of caregiver burden in dementia. The memory disorders clinic. Legal aspects of dementia. Ethical issues in the care of the patient with dementia. Economical aspects of dementia. Neuropathologic classification of dementias: introduction. Tau, a biological marker of neurodegenerative diseases. Biologic models of neurodegenerative disorders. The relationship between nosology, etiology and pathogenesis in neurodegenerative diseases.

    Section 2: Specific disorders:

    Alzheimer's disease:

    Alzheimer's disease: epidemiology. Clinical symptoms in Alzheimer's disease. Mild cognitive impairment. The genetics of Alzheimer's disease. Neuropathology of Alzheimer's disease. Biochemistry and molecular biology of amyloid -protein and the mechanism of Alzheimer's disease. Biological CSF Markers of Alzheimer¡¦s disease. Symptomatic therapeutic aspects in Alzheimer's disease. Perspectives of Alzheimer's disease treatments. Biological transgenic mouse models of Alzheimer's disease.

    Lewy body diseases:

    Clinical aspects of Parkinson dementia. Clinical aspects of dementia with Lewy bodies. The genetics and molecular biology of alpha-synuclein. Neuropathology of dementia with Lewy bodies.

    Frontotemporal dementias:

    Epidemiological aspects of frontotemporal dementia. Frontemporal lobar degeneration: clinical and pathologic overview. Clinical aspects of hereditary frontotemporal dementia. Clinical aspects of TDP-43 proteinopathy, neurofilament inclusion body disease and dementias lacking distinctive proteinopathy. The genetics of frontotemporal dementia. Neuropathology of hereditary forms of frontotemporal dementia and parkinsonismNeuropathology of Pick body disease. Dementia and motor neuron disease. Neuronal intermediate filament inclusion disease. Biological models in frontotemporal dementias.

    Progressive supranuclear palsy :

    The epidemiology of progressive supranuclear palsy. Clinical aspects of progressive supranuclear palsy. Genetics of progressive supranuclear palsy. Neuropathology of progressive supranuclear palsy. Current and future therapeutic approaches in progressive supranuclear palsy.

    Corticobasal degeneration:

    Corticobasal degeneration: clinical aspects. Neuropathology and genetics of corticobasal degeneration. Current and future management of the corticobasal syndrome and corticobasal degeneration.

    Agyrophilic grains

    Clinical aspects of dementia with argyrophilic grains. Argyrophilic grain disease.

    Hippocampal sclerosis:

    Clinical aspects of hippocampal sclerosis. Neuropathology of hippocampal sclerosis.

    Primary progressive aphasias:

    Primary progressive aphasia and kindred disorders.

    Huntington¡¦s disease:

    Pre-symptomatic Huntington's disease. Neuropathology of Huntington's disease. The biology of Huntington's disease. Therapeutic approach in Huntington's disease.

    Vascular dementias:

    The epidemiology of vascular dementia. Clinical and therapeutic aspects of vascular dementia. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy . The neuropathology of vascular and mixed dementia and vascular cognitive impairment.

    Demyelinating disorders:

    Understanding and managing cognitive dysfunction in multiple sclerosis. Neuropathology of cognitive dysfunction in multiple sclerosis. Leukodystrophies: clinical and therapeutic aspects.

    Transmissable diseases

    Clinical and therapeutic aspects of prion disease. Clinical aspects of variant Creutzfeldt-Jakob disease. Biology and neuropathology of prion diseases. Human immunodeficiency virus-associated dementia: clinical aspects, biology, and treatment. Neuropathology and HIV dementia. Clinical and therapeutic aspects of dementia in syphilis and Lyme disease. Biology and neuropathology of dementia in syphilis and Lyme disease.

    Toxic diseases:

    Epidemiology of alcohol-related dementia. Toxic dementias. Neuropathology of alcohol-related cognitive alterations.


    Paraneoplastic disorders of the memory and cognition: clinical aspects and therapeutic approaches. Brain tumors and dementia.


    Clinical aspects and biology of normal pressure hydrocephalus.

Product details

  • No. of pages: 936
  • Language: English
  • Copyright: © Elsevier 2008
  • Published: June 9, 2008
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444518989
  • eBook ISBN: 9780080559865

About the Editors

Charles Duyckaerts

Affiliations and Expertise

Lab de Neuropath R Escourolle, Paris, France

Irene Litvan

Affiliations and Expertise

Raymond Lee Lebby Professor of Parkinson Disease Research, Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA Raymond Lee Lebby Professor of Parkinson Disease Research

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