This volume provides a comprehensive understanding of the biology of dementias, including information on advancements in the way these disorders are perceived and studied. From earlier assumptions that cognitive deficits were simply age related, this handbook progresses into complex discussions of the diseases that affect the cortex of the human brain.

Clinicians will find extensive diagnostic and research perspectives on a variety of interesting topics, including neuropathology, physiopathology, biology, clinics, and imaging information on all, or most, of the dementing disorders currently known.

In addition, chapters devoted to legal and ethical issues give practitioners and health care workers an informative view on complex dementias and the way these disorders affect patients and families. Clinicians in all levels of expertise will find useful and synthetic information.

Key Features

* Comprehensive information on advancements in the study and diagnosis of dementias
* Complex discussions of the diseases that affect the cortex of the human brain
* Extensive diagnostic and research perspectives on topics including, but not limited to, neuropathology, physiopathology, and groundbreaking imaging techniques
* A reference guide that is appropriate for clinicians in all levels of expertise, from researchers to basic health care providers


Neurologists and neuroscience research workers

Table of Contents

Section 1: General aspects:

History of dementia. Neuropsychological examination in dementia. Executive dysfunction and neuropsychological testing. Neuropsychiatric evaluation in dementia. Electrophysiological evaluation of dementia. Feature extraction and strategy of analyzing structural neuroimaging in dementia. Strategies for using molecular neuroimaging in dementia. Quality of life in dementias. Diagnosis and management of caregiver burden in dementia. The memory disorders clinic. Legal aspects of dementia. Ethical issues in the care of the patient with dementia. Economical aspects of dementia. Neuropathologic classification of dementias: introduction. Tau, a biological marker of neurodegenerative diseases. Biologic models of neurodegenerative disorders. The relationship between nosology, etiology and pathogenesis in neurodegenerative diseases.

Section 2: Specific disorders:

Alzheimer's disease:

Alzheimer's disease: epidemiology. Clinical symptoms in Alzheimer's disease. Mild cognitive impairment. The genetics of Alzheimer's disease. Neuropathology of Alzheimer's disease. Biochemistry and molecular biology of amyloid -protein and the mechanism of Alzheimer's disease. Biological CSF Markers of Alzheimer¡¦s disease. Symptomatic therapeutic aspects in Alzheimer's disease. Perspectives of Alzheimer's disease treatments. Biological transgenic mouse models of Alzheimer's disease.

Lewy body diseases:

Clinical aspects of Parkinson dementia. Clinical aspects of dementia with Lewy bodies. The genetics and molecular biology of alpha-synuclein. Neuropathology of dementia with Lewy bodies.

Frontotemporal dementias:

Epidemiological aspects of frontotemporal dementia. Frontemporal lobar degeneration: clinical and pathologic overview. Clinical aspects of hereditary frontotemporal dementia. Clinical aspects of TDP-43 proteinopathy, neuro


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© 2008
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