De Novo Peptide Design

De Novo Peptide Design

Principles and Applications

1st Edition - September 1, 2022

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  • Editors: Vibin Ramakrishnan, Kirti Patel, Ruchika Goyal
  • Paperback ISBN: 9780323999175

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Description

De novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the design of peptides, particularly how peptides may be tailored to specific functions. It includes computational and experimental protocols to assist in the design of peptides. Sections cover the basics of protein and peptide structure, modeling and simulation, solid phase peptide synthesis, peptide-based antibiotics, drug delivery, peptide nanomaterials, aromatic interactions directing nano-assembly, protein/peptide aggregation, therapeutic interventions against protein/peptide aggregation diseases, peptide based hydrogels, computational tools and algorithms for peptide design, and experimental protocols in peptide chemistry. In addition, the book covers key aspects in peptide design, providing a solution for researchers working within the 'peptidic universe' to create new therapeutic agents.

Key Features

  • Gives comprehensive coverage, including peptide design, modeling, synthesis and applications
  • Presents emerging topics in the design of peptide-based therapeutics
  • Details the latest developments in the fields of therapeutic peptides and bio-nanotechnology
  • Considers peptide design and the tailoring of peptides to specific functions
  • Offers computational tools and algorithms for peptide design and experimental protocols for peptide chemistry

Readership

Advanced students in biotechnology, pharmacy, chemistry and chemical engineering; Researchers working in the broad area of medicinal chemistry and peptides

Table of Contents

  • 1. Basics of Protein and peptide structure
    2. Modelling and simulation of Peptides
    3. Solid phase peptide synthesis
    4. Peptide based antibiotics
    5. Drug delivery vehicles
    6. Peptide nanomaterials
    7. Aromatic interactions directing nano-assembly
    8. Protein/peptide aggregation
    9. Therapeutic interventions against protein/peptide aggregation diseases
    10. Peptide based hydrogels
    11. Computational tools and algorithms in peptide design
    12. Experimental protocols in peptide chemistry

Product details

  • No. of pages: 210
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323999175

About the Editors

Vibin Ramakrishnan

Dr. Vibin Ramakrishnan is a Professor of Biosciences and Bioengineering at IIT Guwahati. Dr. Vibin earned his Master’s in Applied Chemistry from Cochin University of Science and Technology and Ph.D. from School of Biosciences and Bioengineering, IIT Bombay. He worked as a Postdoctoral Research Associate at Rennsselaer Polytechnic Institute, New York and a Faculty scientist at IBAB Bangalore, before joining Department of Biosciences & Bioengineering at IIT Guwahati. He has 42 publications in reputed international journals and 10 patents, including an international patent to his credit. He is the principal scientific advisor of two biotech companies. The Department of Biotechnology, Govt. of India has awarded Vibin, the Innovative Young Biotechnologist Award (IYBA) in the year 2007-08 to recognize his contributions and innovative approach in biotechnology research

Affiliations and Expertise

Professor of Biosciences and Bioengineering, IIT Guwahati, India

Kirti Patel

Dr. Kirti Patel is Assistant Professor of Chemistry at N. B. Mehta Science College, affiliated to University of Mumbai. Dr. Patel earned his Master’s in Organic Chemistry from University of Pune and PhD from Department of Chemistry, IIT Bombay. He worked as an Assistant Professor at Bytco College, Nashik before joining N. B. Mehta Science College, Mumbai University. His research work is mostly concentrated in developing peptide based biomaterials, and he has already published 10 research papers in this area

Affiliations and Expertise

Assistant Professor of Chemistry at N. B. Mehta Science College, affiliated to University of Mumbai, India

Ruchika Goyal

Dr. Ruchika Goyal is a Post-doctoral researcher, presently associated with IIT Guwahati. She did her B.Tech in Biotechnology from G. B. Pant University and Masters from Graphic Era University before joining for her doctoral research at IIT Guwahati. Dr. Goyal has 6 years’ research experience in Solid-Phase Peptide Synthesis, High Performance Liquid Chromatography, Mass Spectrometry, Mammalian Cell Culture, Flow Cytometry, Fluorescence Microscopy, Fluorescence Spectroscopy, Immunohistochemistry, and Small animal handling. Her doctoral studies focus on peptide based drug delivery systems. She has half a dozen publications and a patent to her credit

Affiliations and Expertise

Post-doctoral researcher, presently associated with IIT Guwahati, India

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