Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

1st Edition - October 14, 2021
  • Editor: Vladimir Uversky
  • eBook ISBN: 9780323853002
  • Hardcover ISBN: 9780323852999

Purchase options

Purchase options
DRM-free (PDF, EPub)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more.

Key Features

  • Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases
  • Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided
  • Includes contributions from recognized experts in the field


Scientists working in the fields of biochemistry, biophysics, molecular medicine, biotechnology, pharmacology and drug discovery, molecular and cellular biology, as well as students of Medical Schools, Departments of Biochemistry, Biophysics, Molecular Biology, Biotechnology, Cell Biology, etc. This book is of interest to everybody, who is fascinated by the protein intrinsic disorder phenomenon, including graduate students, postdoctoral students, and experienced researchers studying intrinsically disordered proteins (IDPs), their structures, and functions

Table of Contents

  • 1. Intrinsic disorder and phase transitions: Pieces in the puzzling role of the prion protein in health and disease

    Mariana J. do Amaral and Yraima Cordeiro

    2. Functions of intrinsically disordered proteins through evolutionary lenses

    Mátyás Pajkos and Zsuzsanna Dosztányi

    3. Non-specific porins of Gram-negative bacteria as proteins containing intrinsically disordered regions with amyloidogenic potential

    Olga D. Novikova, Vladimir N. Uversky and Elena A. Zelepuga

    4. Intrinsic disorder in integral membrane proteins

    Brian J. Aneskievich, Rambon Shamilov and Olga Vinogradova

    5. Molecular simulations of IDPs: From ensemble generation to IDP interactions leading to disorder-to-order transitions

    Hebah Fatafta, Suman Samantray, Abdallah Sayyed-Ahmad, Orkid Coskuner-Weber and Birgit Strodel

    6. Target-binding behavior of IDPs via pre-structured motifs

    Do-Hyoung Kim and Kyou-Hoon Han

    7. The role of dancing duplexes in biology and disease

    Heather M. Forsythe and Elisar Barbar

    8. Intrinsic disorder in protein kinase A anchoring proteins signaling complexes

    Mateusz Dyla and Magnus Kjaergaard

    9. Protein intrinsic disorder on a dynamic nucleosomal landscape

    Sveinn Bjarnason, Sarah F. Ruidiaz, Jordan McIvor, Davide Mercadante and Pétur O. Heidarsson

    10. Flexible spandrels of the global plant virome: Proteomic-wide evolutionary patterns of structural intrinsic protein disorder elucidate modulation at the functional virus–host interplay

    Rachid Tahzima, Annelies Haegeman, Sébastien Massart and Eugénie Hébrard

Product details

  • No. of pages: 434
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: October 14, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780323853002
  • Hardcover ISBN: 9780323852999

About the Serial Volume Editor

Vladimir Uversky

Vladimir Uversky
VLADIMIR N. UVERSKY is a Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF). He obtained his academic degrees from Moscow Institute of Physics and Technology (Ph.D., in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (D.Sc., in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, he moved to the University of California Santa Cruz where for six years he was studying protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomenon. In 2004, he was invited to join the Indiana University School of Medicine as a Senior Research Professor to work on the intrinsically disordered proteins. Since 2010, Professor Uversky is with USF, where he continues to study intrinsically disordered proteins and protein folding and misfolding processes. He has authored over 950 scientific publications and edited several books and book series on protein structure, function, folding and misfolding.

Affiliations and Expertise

Professor, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, USA