Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B - 1st Edition - ISBN: 9780128226155

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, Volume 174

1st Edition

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Serial Volume Editors: Vladimir N. Uversky
Hardcover ISBN: 9780128226155
Imprint: Academic Press
Published Date: 1st September 2020
Page Count: 300
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Table of Contents

1. Intrinsically disordered proteins of viruses: involvement in the mechanism of cell regulation and pathogenesis
Chayan K. Nandi and Pushpendra Mani Mishra
2. Using molecular simulations to study IDPs
Paul Robustelli
3. Fluctuation, allostery, and binding in a mode analysis of protein dynamics
Marina Guenza
4. The Balance between Liquid-Liquid Phase Separation and Fibrillization in Neurodegenerative Diseases
Benjamin Wolozin
5. Intrinsic disorder and Hox transcription factor function
Sarah Bondos
6. The many faces of IDPs, from protocells to modern cells
Ashok Deniz
7. Dancing while self-eating: Protein intrinsic disorder in autophagy
Hana Popelka
8. Intrinsic disorder in the nickel-dependent urease network
Barbara Zambelli


"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Key Features

  • Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases
  • Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided
  • Includes contributions from recognized experts in the field


Scientists working in the fields of biochemistry, biophysics, molecular medicine, biotechnology, pharmacology and drug discovery, molecular and cellular biology, as well as students of Medical Schools, Departments of Biochemistry, Biophysics, Molecular Biology, Biotechnology, Cell Biology, etc. This book is of interest to everybody, who is fascinated by the protein intrinsic disorder phenomenon, including graduate students, postdoctoral students, and experienced researchers studying intrinsically disordered proteins (IDPs), their structures, and functions


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© Academic Press 2020
1st September 2020
Academic Press
Hardcover ISBN:

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About the Serial Volume Editors

Vladimir N. Uversky

VLADIMIR N. UVERSKY is a Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF). He obtained his academic degrees from Moscow Institute of Physics and Technology (Ph.D., in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (D.Sc., in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, he moved to the University of California Santa Cruz where for six years he was studying protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomenon. In 2004, he was invited to join the Indiana University School of Medicine as a Senior Research Professor to work on the intrinsically disordered proteins. Since 2010, Professor Uversky is with USF, where he continues to study intrinsically disordered proteins and protein folding and misfolding processes. He has authored over 850 scientific publications and edited several books and book series on protein structure, function, folding and misfolding.

Affiliations and Expertise

University of South Florida, USA