Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

1st Edition - August 19, 2020

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  • Editor: Vladimir Uversky
  • eBook ISBN: 9780128226049
  • Hardcover ISBN: 9780128226155

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Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Key Features

  • Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases
  • Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided
  • Includes contributions from recognized experts in the field


Scientists working in the fields of biochemistry, biophysics, molecular medicine, biotechnology, pharmacology and drug discovery, molecular and cellular biology, as well as students of Medical Schools, Departments of Biochemistry, Biophysics, Molecular Biology, Biotechnology, Cell Biology, etc. This book is of interest to everyone fascinated by the protein intrinsic disorder phenomenon, including graduate students, postdoctoral students, and experienced researchers studying intrinsically disordered proteins (IDPs), their structures, and functions

Table of Contents

  • Preface
    Vladimir N. Uversky
    1. Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis
    Pushpendra Mani Mishra, Navneet C Verma, Chethana Rao, Vladimir N Uversky and Chayan K Nandi
    2. Transient knots in intrinsically disordered proteins and neurodegeneration
    Marek Cieplak, Mateusz Chwastyk, Łukasz Mioduszewski and Belisa R. H. de Aquino
    3. IDPs and their complexes in GPCR and nuclear receptor signaling
    Myriam Guillien, Albane le Maire, Assia Mouhand, Pau Bernadó, William Bourguet, Jean-Louis Banères and Nathalie Sibille
    4. Intrinsic disorder-based design of stable globular proteins
    Galina S. Nagibina, Tatiana N. Melnik, Ksenia A. Glukhova, Vladimir N. Uversky and Bogdan S. Melnik
    5. The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation
    Chelsea J. Webber, Shuwen (Eric) Lei and Benjamin Wolozin
    6. Context-dependent HOX transcription factor function in health and disease 
    Sarah E. Bondos, Gabriela Geraldo Mendes and Amanda Jons
    7. Dancing while self-eating: Protein intrinsic disorder in autophagy
    Hana Popelka
    8. Intrinsic disorder in the nickel-dependent urease network
    Barbara Zambelli, Luca Mazzei and Stefano Ciurli
    9. Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functions
    Anukool A. Bhopatkar, Vladimir N. Uversky and Vijayaraghavan Rangachari

Product details

  • No. of pages: 402
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: August 19, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128226049
  • Hardcover ISBN: 9780128226155

About the Serial Volume Editor

Vladimir Uversky

Vladimir Uversky
Dr. Uversky is a Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF). He spent his early career working mostly on protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, he moved to the University of California Santa Cruz where for six years he was studying protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomenon. In 2004, he was invited to join the Indiana University School of Medicine as a Senior Research Professor to work on intrinsically disordered proteins. Since 2010, Professor Uversky is with USF, where he continues to study intrinsically disordered proteins and protein folding and misfolding processes. Prof. Uversky has authored over 1,050 scientific publications and edited several books and book series. He has collaborated with more than 12,500 colleagues from over 2,750 research organizations in 89 countries/territories.

Affiliations and Expertise

Professor, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, USA

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