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Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B - 1st Edition - ISBN: 9780128226155

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, Volume 174

1st Edition

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Serial Volume Editor: Vladimir N. Uversky
Hardcover ISBN: 9780128226155
Imprint: Academic Press
Published Date: 1st September 2020
Page Count: 300
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Table of Contents

Preface
Vladimir N. Uversky
1. Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis
Pushpendra Mani Mishra, Navneet C Verma, Chethana Rao, Vladimir N Uversky and Chayan K Nandi
2. Transient knots in intrinsically disordered proteins and neurodegeneration
Marek Cieplak, Mateusz Chwastyk, Łukasz Mioduszewski and Belisa R. H. de Aquino
3. IDPs and their complexes in GPCR and nuclear receptor signaling
Myriam Guillien, Albane le Maire, Assia Mouhand, Pau Bernadó, William Bourguet, Jean-Louis Banères and Nathalie Sibille
4. Intrinsic disorder-based design of stable globular proteins
Galina S. Nagibina, Tatiana N. Melnik, Ksenia A. Glukhova, Vladimir N. Uversky and Bogdan S. Melnik
5. The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation
Chelsea J. Webber, Shuwen (Eric) Lei and Benjamin Wolozin
6. Context-dependent HOX transcription factor function in health and disease 
Sarah E. Bondos, Gabriela Geraldo Mendes and Amanda Jons
7. Dancing while self-eating: Protein intrinsic disorder in autophagy
Hana Popelka
8. Intrinsic disorder in the nickel-dependent urease network
Barbara Zambelli, Luca Mazzei and Stefano Ciurli
9. Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functions
Anukool A. Bhopatkar, Vladimir N. Uversky and Vijayaraghavan Rangachari


Description

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Key Features

  • Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases
  • Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided
  • Includes contributions from recognized experts in the field

Readership

Scientists working in the fields of biochemistry, biophysics, molecular medicine, biotechnology, pharmacology and drug discovery, molecular and cellular biology, as well as students of Medical Schools, Departments of Biochemistry, Biophysics, Molecular Biology, Biotechnology, Cell Biology, etc. This book is of interest to everyone fascinated by the protein intrinsic disorder phenomenon, including graduate students, postdoctoral students, and experienced researchers studying intrinsically disordered proteins (IDPs), their structures, and functions


Details

No. of pages:
300
Language:
English
Copyright:
© Academic Press 2020
Published:
1st September 2020
Imprint:
Academic Press
Hardcover ISBN:
9780128226155

Ratings and Reviews


About the Serial Volume Editor

Vladimir N. Uversky

VLADIMIR N. UVERSKY is a Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF). He obtained his academic degrees from Moscow Institute of Physics and Technology (Ph.D., in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (D.Sc., in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, he moved to the University of California Santa Cruz where for six years he was studying protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomenon. In 2004, he was invited to join the Indiana University School of Medicine as a Senior Research Professor to work on the intrinsically disordered proteins. Since 2010, Professor Uversky is with USF, where he continues to study intrinsically disordered proteins and protein folding and misfolding processes. He has authored over 850 scientific publications and edited several books and book series on protein structure, function, folding and misfolding.

Affiliations and Expertise

University of South Florida, USA