Cytokine Effector Functions in Tissues

Cytokine Effector Functions in Tissues

1st Edition - July 17, 2017

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  • Editors: Maria Foti, Massimo Locati
  • Paperback ISBN: 9780128042144
  • eBook ISBN: 9780128042199

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Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types.

Key Features

  • Categorizes the cytokines based primarily on tissue and target cells
  • Emphasizes different roles and outcomes observed during innate and adaptive response
  • Represents a rapid guide to cytokines in health and disease in tissue and organ context
  • Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells


Researchers in immunology, cytokines research, molecular biology, genetics, biochemistry, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines

Table of Contents

  • Preface

      Maria Foti

    Cytokines as Tissue Regulators in Health and Disease

      Maria Foti

    I. Cytokine Tissue Specific Regulation

    1. Cytokine and the Adipose Tissue

      Isabelle Wolowczuk

    2. Cytokine and Ovary

      Nicolas Michel Orsi

    3. Cytokine and the Liver

      Pietro Invernizzi

    II. Cytokines Regulation in Disease

    4. Cytokines in Osteoarthritis

      Mohit Kapoor

    5. Cytokines in Atherosclerosis

      Dipak Purshottam Ramji

    6. Cytokines and Diabetes

      Juan F. Navarro-Gonzalez

    7. Cytokines and Sarcoidosis

      Paul S. Thomas

    8. Cytokine and Nerve Degeneration

      P. Dubovy

    9. Cytokine and Skeletal Muscle Disease

      Boel De Paepe

    10. Airway epithelial cytokines in asthma and chronic obstructive pulmonary diseas

      Rakesh K. Kumar

    11. Eosinophils Cytokines and Allergies

      Paige Lacy

    12. Cytokine in Transplantation

      Geoff Hill and Kate Markey

    III. Cytokines and Therapeutic Applications

    13. Cytokine Therapies in CANCER

      Ruth Ganss

    14. MSCs Cytokines as cellular Therapies

      Dobroslav Kyurkchiev

Product details

  • No. of pages: 304
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: July 17, 2017
  • Imprint: Academic Press
  • Paperback ISBN: 9780128042144
  • eBook ISBN: 9780128042199

About the Editors

Maria Foti

Maria Foti is Assistant Professor at the University of Milano-Bicocca. She is an internationally recognized immunologist/molecular biologist with experience in both academic science and biotechnology. She has worked for several years in the field of molecular immunology and cell biology of Dendritic Cells. She studied the molecular events associated with Dendritic cell early responses, suggesting the role of Dendritic Cells as the key players in the innate immune responses. Dr. Foti's lab has a focus on cytokine research including the role of cytokines produced by Dendritic cells in response to pathogens. She has been also involved in projects for the selection of biomarkers using the microarray technology in the field of cancer and Autoimmunity.

Affiliations and Expertise

University of Milano-Bicocca, Italy

Massimo Locati

Massimo Locati is Full Professor of General Pathology and Immunology at the Department of Medical Biotechnologies and Translational Medicine at the University of Milan and chief of the Leukocyte Biology Lab at the Humanitas Clinical and Research Center in Rozzano, Milan. His current scientific research interests are represented by cellular and molecular mechanisms involved in resolution of inflammation, identification of the biological role of chemokine decoy receptors, definition of chemokine receptors signalling properties and associated transcriptional events investigation of molecular mechanisms supporting macrophage activation and polarization, and role of regulatory RNA in innate immunity and immune- mediated diseases .

Affiliations and Expertise

Department of Medical Biotechnonology,University of Milan, Milan, Italy

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