Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis

Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis

1st Edition - July 29, 2022

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  • Editors: William Hasler, David Levinthal, Thangam Venkatesan
  • Paperback ISBN: 9780128215975

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Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis comprehensively covers the varied aspects of both adult cyclic vomiting syndrome (CVS) and cannabinoid hyperemesis syndrome (CHS). The book clearly differentiates CVS and CHS from other vomiting syndromes in terms of presentation, diagnosis and treatment options, providing the necessary information to understand the disorders and present appropriate care for patients while also including enough background to help investigators studying these disorders. Compiled by experts in the field of motility and written by experts in several disciplines, this reference provides an evidence-based approach to the management, treatment and research of CVS and cannabinoid hyperemesis. Important topics like nervous system pathways of nausea and vomiting, clinical features, subtypes and insights into pathogenesis and the curious association of hot bathing, CVS and CHS are all explored.  This is a must-have reference for residents in training, graduate and medical students in gastroenterology, and those dealing with CVS and CHS in general medical care, emergency care and in substance use/abuse.

Key Features

  • Outlines the physiology and known contributors to the development of adult cyclic vomiting syndrome (CVS) to guide in the further investigation and treatment of adult cyclic vomiting syndrome
  • Provides the definition and recognition of adult CVS to help organize and guide patient care
  • Explores cannabinoid hyperemesis syndrome (CHS) and its relationship to adult CVS


Gastroenterologists, gastroenterology researchers, physicians; Residents in training, and graduate and medical students in gastroenterology, general medical care, emergency care, and substance use/abuse

Table of Contents

  • 1. The patient and caregiver experiences
    2. Central nervous system pathways of nausea and vomiting
    3. Clinical features of cyclic vomiting syndrome (CVS)
    4. Is pediatric CVS different from adult CVS?
    5. CVS subtypes - do they provide insight into CVS pathogenesis?
    6. Clinical and pathophysiologic relation of migraines to CVS
    7. Psychosocial contributors to CVS
    8. Treatment of acute CVS attacks
    9. Prevention of recurrent CVS episodes
    10. Clinical features of CVS
    11. How common is CVS and why is it so hard to diagnose?
    12. Proposed mechanisms of CHS - how can cannabinoid pathways both relieve and cause vomiting?
    13. The curious association of hot bathing with CHS and CVS
    14. Management of CHS - is it more than just avoiding cannabis use?
    15. Role of the emergency department in CVS and CHS care
    16. international differences in CVS and CHS management

Product details

  • No. of pages: 358
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 29, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128215975

About the Editors

William Hasler

William L. Hasler, MD is a faculty member in the Gastroenterology Division of the University of Michigan Health System. His research and clinical interests center on disorders of gastrointestinal motility. He has authored over160 peer-reviewed articles, over 50 book chapters, and edited eight books. Dr. Hasler serves as associate editor for Gastroenterology. He was a member of the Rome IV Committee to revise diagnostic criteria for functional bowel disorders and is a member of the Practice Guidelines Committee to devise standard management approaches to cyclic vomiting syndrome. He maintains an active clinical practice serving patients with dysmotility syndromes including gastroparesis, intestinal pseudo-obstruction, colonic inertia and other conditions with refractory nausea, vomiting and constipation. For his patient care, Dr. Hasler was elected to the Clinical Excellence Society at the University of Michigan in 2016.

Affiliations and Expertise

Mayo Clinic Arizona, Scottsdale, Arizona, USA

David Levinthal

David J. Levinthal’s lab uses both neuroanatomical tracing and neurophysiological techniques to explore the neural basis for central nervous system influences over autonomic regulation in both health and disease. Dr. Levinthal's research focuses on the neural mechanisms by which the cerebral cortex influences GI tract function. Initial studies have uncovered the surprising finding that a visceromotor map of sympathetic function is embedded within the classic cortical somatotopic map of motor function. Further work is aimed at understanding the cortical regions that influence vagal function. The goal of this effort is to use the visceral maps to guide brain stimulation as a means to influence GI tract function. This line of work will lead to the development of brain-based therapies for those with forms of severe GI dysfunction refractory to standard treatments.

Affiliations and Expertise

University of Pittsburgh Medical Center, USA

Thangam Venkatesan

Thangam Venkatesan has been with the Division of Gastroenterology and Hepatology since 2004. She is actively involved in all four missions of the Medical College of Wisconsin: patient care, education, research and community outreach. She is currently the Fellowship Program Director. Her area of clinical expertise and scientific interest is in a condition called Cyclic Vomiting Syndrome (CVS), characterized by recurrent episodes of nausea and vomiting. She conducts translational research exploring the neurobiology of nausea and vomiting in patients with CVS. Dr. Venkatesan has established a clinic for the care of CVS patients that serves as a destination for patients from 48 states as well as Canada and Puerto Rico. Additionally, she serves as the Chief Medical Advisor of the Cyclic Vomiting Syndrome Association (CVSA).

Affiliations and Expertise

Professor of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Ohio State University, Columbus, Ohio

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