Cyclic AMP
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Cyclic AMP provides information pertinent to cyclic adenosine 3',5'-monophosphate (AMP), a regulatory agent that controls the rate of a number of cellular processes. This book discusses the heat-stable factor mediating the action of glucagon and epinephrine on the activation of liver phosphorylase. Organized into 12 chapters, this book starts with an overview of the biological role of cyclic AMP, which is extended from a relatively simple role in liver glycogenolysis to a significant regulatory agent in most mammalian tissues. This text then discusses the development that led to the discovery of the heat-stable factor from investigations with cyclic nucleotides. Other chapters explore the chemical agents, which are released from one group of cells and travel via the bloodstream to affect one or more different groups of cells. The final chapter discusses the role of cyclic AMP to mammalian physiology, with emphasis on the many possible defects that may lead to human disease. This book is a valuable resource for graduate students and clinical investigators involved in biological and biomedical sciences.
Table of Contents
Preface
Chapter 1. An Introduction
I. Glycogenolysis
II. Activation of Phosphorylase
III. Chemical Nature of Phosphorylase Activation
IV. The Identification of Cyclic AMP
Chapter 2. Cyclic AMP and Hormone Action
I. Introduction
II. Hormones
III. Receptors and Second Messengers
IV. The Intracellular Level of Cyclic AMP
V. Experimental Approaches Used in the Study of Hormones which Stimulate Adenyl Cyclase
VI. Two Major Problems
VII. Addendum
Chapter 3. Chemistry of Cyclic Nucleoside Phosphates and Synthesis of Analogs
I. Chemistry of Cyclic Nucleoside Phosphates
II. Derivatives of Cyclic AMP
III. Recent Progress
Chapter 4. Formation and Metabolism of Cyclic AMP
I. Adenyl Cyclase
II. Phosphodiesterase
III. Addendum
Chapter 5. Some Actions of Cyclic AMP
I. Introduction
II. Effects of Exogenously Administered Cyclic AMP
III. Effects on Enzymes
IV. Effects on Protein Synthesis
V. Other Effects of Cyclic AMP
VI. Addendum
Chapter 6. The Catecholamines
I. Introduction
II. Adrenergic Receptors
III. Effects on Carbohydrate Metabolism
IV. The Calorigenic Effect
V. Some Other Metabolic Effects
VI. Some Functional Effects of Adrenergic Stimulation
VII. Other Factors Influencing Adrenergic Responses Involving Cyclic AMP
VIII. General Considerations and Summary
IX. Addendum
Chapter 7. Glucagon and Insulin
I. Introduction
II. Glucagon
III. Insulin
IV. Addendum
Chapter 8. Lipolysis in Adipose Tissue
I. Introduction
II. The Role of Cyclic AMP in the Actions of Lipolytic Hormones
III. Agents which Decrease Cyclic AMP Levels and Lipolysis in Adipose Tissue
IV. Phosphodiesterase Inhibitors
V. Other Factors Controlling Lipolysis which May Involve Cyclic AMP Directly or Indirectly
VI. Summary
VII. Addendum
Chapter 9. Cyclic AMP and Steroidogenesis
I. Introduction
II. The Adrenal Cortex
III. Cyclic AMP and Steroidogenesis in the Gonads
IV. Summary
V. Addendum
Chapter 10. Other Hormones
I. Vasopressin
II. Thyroid Stimulating Hormone
III. MSH and Melatonin
IV. Hormones Regulating Calcium Homeostasis
V. Gastrointestinal Hormones
VI. Histamine
VII. Serotonin
VIII. Acetylcholine
IX. The Prostaglandins
X. Hypothalamic Releasing Hormones
XI. Thyroid Hormone
XII. Steroid Hormones
XIII. Growth Hormone
XIV. Some Bacterial and Plant Products
XV. Summary
Chapter 11. Other Cyclic Nucleotides
I. Introduction
11. Methods of Detection
III. Cyclic GMP in Tissues
IV. Guanyl Cyclase
V. Hydrolysis of Cyclic GMP by Cyclic Nucleotide Phosphodiesterase(s)
VI. Effects of Cyclic GMP
VII. Cyclic GMP and Cyclic AMP in Urine
VIII. Summary
IX. Addendum
Chapter 12. Cyclic AMP in Lower Organisms
I. Introduction
II. Bacteria
III. Cellular Slime Molds
IV. Cancer
V. Other Organisms
VI. Concluding Remarks
Appendix
References
Subject Index
Product details
- No. of pages: 544
- Language: English
- Copyright: © Academic Press 1971
- Published: January 1, 1971
- Imprint: Academic Press
- eBook ISBN: 9780323146487