Cyclic AMP

Cyclic AMP

1st Edition - January 1, 1971

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  • Author: G Robison
  • eBook ISBN: 9780323146487

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Cyclic AMP provides information pertinent to cyclic adenosine 3',5'-monophosphate (AMP), a regulatory agent that controls the rate of a number of cellular processes. This book discusses the heat-stable factor mediating the action of glucagon and epinephrine on the activation of liver phosphorylase. Organized into 12 chapters, this book starts with an overview of the biological role of cyclic AMP, which is extended from a relatively simple role in liver glycogenolysis to a significant regulatory agent in most mammalian tissues. This text then discusses the development that led to the discovery of the heat-stable factor from investigations with cyclic nucleotides. Other chapters explore the chemical agents, which are released from one group of cells and travel via the bloodstream to affect one or more different groups of cells. The final chapter discusses the role of cyclic AMP to mammalian physiology, with emphasis on the many possible defects that may lead to human disease. This book is a valuable resource for graduate students and clinical investigators involved in biological and biomedical sciences.

Table of Contents

  • Preface

    Chapter 1. An Introduction

    I. Glycogenolysis

    II. Activation of Phosphorylase

    III. Chemical Nature of Phosphorylase Activation

    IV. The Identification of Cyclic AMP

    Chapter 2. Cyclic AMP and Hormone Action

    I. Introduction

    II. Hormones

    III. Receptors and Second Messengers

    IV. The Intracellular Level of Cyclic AMP

    V. Experimental Approaches Used in the Study of Hormones which Stimulate Adenyl Cyclase

    VI. Two Major Problems

    VII. Addendum

    Chapter 3. Chemistry of Cyclic Nucleoside Phosphates and Synthesis of Analogs

    I. Chemistry of Cyclic Nucleoside Phosphates

    II. Derivatives of Cyclic AMP

    III. Recent Progress

    Chapter 4. Formation and Metabolism of Cyclic AMP

    I. Adenyl Cyclase

    II. Phosphodiesterase

    III. Addendum

    Chapter 5. Some Actions of Cyclic AMP

    I. Introduction

    II. Effects of Exogenously Administered Cyclic AMP

    III. Effects on Enzymes

    IV. Effects on Protein Synthesis

    V. Other Effects of Cyclic AMP

    VI. Addendum

    Chapter 6. The Catecholamines

    I. Introduction

    II. Adrenergic Receptors

    III. Effects on Carbohydrate Metabolism

    IV. The Calorigenic Effect

    V. Some Other Metabolic Effects

    VI. Some Functional Effects of Adrenergic Stimulation

    VII. Other Factors Influencing Adrenergic Responses Involving Cyclic AMP

    VIII. General Considerations and Summary

    IX. Addendum

    Chapter 7. Glucagon and Insulin

    I. Introduction

    II. Glucagon

    III. Insulin

    IV. Addendum

    Chapter 8. Lipolysis in Adipose Tissue

    I. Introduction

    II. The Role of Cyclic AMP in the Actions of Lipolytic Hormones

    III. Agents which Decrease Cyclic AMP Levels and Lipolysis in Adipose Tissue

    IV. Phosphodiesterase Inhibitors

    V. Other Factors Controlling Lipolysis which May Involve Cyclic AMP Directly or Indirectly

    VI. Summary

    VII. Addendum

    Chapter 9. Cyclic AMP and Steroidogenesis

    I. Introduction

    II. The Adrenal Cortex

    III. Cyclic AMP and Steroidogenesis in the Gonads

    IV. Summary

    V. Addendum

    Chapter 10. Other Hormones

    I. Vasopressin

    II. Thyroid Stimulating Hormone

    III. MSH and Melatonin

    IV. Hormones Regulating Calcium Homeostasis

    V. Gastrointestinal Hormones

    VI. Histamine

    VII. Serotonin

    VIII. Acetylcholine

    IX. The Prostaglandins

    X. Hypothalamic Releasing Hormones

    XI. Thyroid Hormone

    XII. Steroid Hormones

    XIII. Growth Hormone

    XIV. Some Bacterial and Plant Products

    XV. Summary

    Chapter 11. Other Cyclic Nucleotides

    I. Introduction

    11. Methods of Detection

    III. Cyclic GMP in Tissues

    IV. Guanyl Cyclase

    V. Hydrolysis of Cyclic GMP by Cyclic Nucleotide Phosphodiesterase(s)

    VI. Effects of Cyclic GMP

    VII. Cyclic GMP and Cyclic AMP in Urine

    VIII. Summary

    IX. Addendum

    Chapter 12. Cyclic AMP in Lower Organisms

    I. Introduction

    II. Bacteria

    III. Cellular Slime Molds

    IV. Cancer

    V. Other Organisms

    VI. Concluding Remarks



    Subject Index

Product details

  • No. of pages: 544
  • Language: English
  • Copyright: © Academic Press 1971
  • Published: January 1, 1971
  • Imprint: Academic Press
  • eBook ISBN: 9780323146487

About the Author

G Robison

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