Cutaneous Innervation

Cutaneous Innervation

Proceedings of the Brown University Symposium on the Biology of Skin, 1959

1st Edition - January 1, 1960

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  • Editor: William Montagna
  • eBook ISBN: 9781483280882

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Advances in Biology of Skin, Vol. I: Cutaneous Innervation focuses on the biology of skin, including the chemistry of the ground substance of the dermis to the biology of sebaceous glands. The selection first offers information on the pattern of cutaneous innervation of the human hand, foot, and breast and similarities in cutaneous nerve end-organs. Discussions focus on the methods of study, observations, histochemical reactions, and function of end-organs. The text then examines the autonomic innervation of the skin, cholinesterases in the cutaneous nerves of man, and the relation of nerve fiber size to modality of sensation. The manuscript ponders on the central paths of the afferent impulses from skin that arouse sensation and studies related to the mechanism of common sensibility, including materials and methods, anatomical and physiological observations, and interpretation of observations. The publication also takes a look at the structures and processes involved in the sensation of itch and the pathophysiology of itch sensation. The selection is a dependable reference for readers interested in the biology of skin.

Table of Contents

  • List of Contributors


    Chapter 1 The Pattern of Cutaneous Innervation of the Human Hand, Foot and Breast

    I. Introduction

    II. Methods of Study

    III. Observations

    A. The Pattern of Cutaneous Innervation of the Hand

    B. The Pattern of Cutaneous Innervation of the Human Foot

    C. The Pattern of Cutaneous Innervation of the Human Breast

    D. The Pattern of Innervation of the Deeper Tissues

    IV. Discussion

    V. Summary

    VI. References

    Chapter II Similarities in Cutaneous Nerve End-Organs

    I. Introduction

    II. The Histochemical Reactions

    III. The Function of End-organs

    IV. Comment

    V. References

    Chapter III The Autonomic Innervation of the Skin

    I. General Discussion

    II. References

    Chapter IV Cholinesterases in the Cutaneous Nerves of Man

    I. Introduction

    II. Cholinesterase in Nerve Endings

    III. The Nerves around the Cutaneous Glands

    IV. The Nerves around Hair Follicles

    V. Comments

    VI. Summary

    VII. References

    Chapter V The Relation of Nerve Fiber Size to Modality of Sensation

    I. Introduction

    II. References

    Chapter VI The Central Paths of the Afferent Impulses from Skin Which Arouse Sensation

    I. Introduction

    A. The Separation of Sensory Paths into Central Tracts

    B. The Central Projections of the Sensory Systems

    C. The Problem of Pain and Temperature Reception

    D. Comparison of Somaesthetic and Visual Sensory Systems

    E. The Large-Fiber System in the Mammalian Cortex

    F. The Development of the Cortex as a Sensory Apparatus

    G. Convergence of the Sensory Paths

    II. References

    Chapter VII Studies Related to the Mechanism of Common Sensibility

    I. Introduction

    II. Material and Methods

    A. Anatomical

    B. Physiological

    III. Anatomical Observations

    A. The Topography of the Ciliary Nerve Bundles

    B. Fiber Content of "Long" and "Short" Ciliary Nerve Bundles

    C. Number of Nerve Fibers Supplying the Cornea Counted at the Limbus

    D. Number of Nerve Fibers 6ì and larger in "Long" and "Mixed" Ciliary Nerve Bundles

    E. The Surface Areas of Cornea Served by the Various Types of Ciliary Nerve Bundles

    IV. Physiological Observations

    A. Activity Evoked in Whole "Long" Ciliary Nerve Bundles by the Application of Various Stimuli to the Cornea

    B. Activity Evoked in Teased Fractions of Fine "Long" Ciliary Nerve Bundles by Brushing and Heat Transfer

    C. Activity Evoked in Teased Fractions of Fine "Long" Ciliary Nerve Bundles by Electrical Stimulation of the Cornea

    D. Control Experiments

    E. The Distribution, in the Cornea, of the Terminals Served by Nerve Fibers of Different Diameters

    F. Anomalous Observations

    V. Interpretation of Observations

    VI. Discussion

    VII. Acknowledgments

    VIII. References

    Chapter VIII Structures and Processes Involved in the Sensation of Itch

    I. Introduction

    II. Demonstration of Lowered Pain Threshold in Areas of Itching

    III. The Qualities of Cutaneous Pain and Itch

    A. Demonstration of Itching Sensation with a Burning Quality

    B. Demonstration of an Itching Sensation with Pricking Quality

    IV. Demonstration that Itch can be Abolished by Painful Pin Pricks within the Same Dermatome

    V. Demonstration that a Zone of Secondary Hyperalgesia Is "Anti-Pruritic"

    VI. Demonstration that Vasodilatation Is Accompanied by Lowered Pain Threshold and Spontaneous Itching

    VII. Demonstration of Heightened Vulnerability in Zones of Vasodilatation

    VIII. Demonstration of a Bradykinin-type Agent in Subcutaneous Perfusate Collected from Zones of Lowered Pain Threshold and Spontaneous Itching

    IX. Comment

    X. Demonstration that Activation of Sweat Glands Is Not a Required Step in Bradykinin Formation during Vasodilatation

    XI. Demonstration that Central Nervous System Activity at the Highest Level Is Implicated in the Activation of Proteolytic Enzymes in the Periphery

    XII. Comment

    XIII. Summary and Conclusions

    XIV. References

    Chapter IX Pathophysiology of Itch Sensation

    I. Pain and Itch

    II. Itch and Protopathic Pain

    III. Physiological and Pathological Pruritus

    IV. Itching Hyperexcitability

    A. Chronic Perianal Eczema with Reddening and Patchy Epidermal Thickening

    B. Chronic Eczema of the Right Hand with Diffuse Reddening, Papules, Blisters, Irregularly Arranged Adherent Scales

    V. Spontaneous Itch and Anatomical Changes

    VI. The Site of Itch Terminals

    VII. Vasomotor Fibers

    VIII. Psychic Factors

    IX. Summary

    X. References

    Subject Index

Product details

  • No. of pages: 216
  • Language: English
  • Copyright: © Pergamon 1960
  • Published: January 1, 1960
  • Imprint: Pergamon
  • eBook ISBN: 9781483280882

About the Editor

William Montagna

Affiliations and Expertise

Oregon Regional Primate Research Center, Beaverton, U.S.A.

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