Current Topics in Experimental Endocrinology - 1st Edition - ISBN: 9780121532024, 9781483217345

Current Topics in Experimental Endocrinology

1st Edition

Volume 2

Editors: V. H. T. James L Martini
eBook ISBN: 9781483217345
Imprint: Academic Press
Published Date: 28th May 1974
Page Count: 264
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Current Topics in Experimental Endocrinology, Volume 2 covers major developments in the ever-expanding field of endocrinology. The book discusses the progress in cyclic nucleotide research; the hypothalamic control of the anterior pituitary hormone secretion-characterized hypothalamic hypophysiotropic peptides; and the pituitary-ovarian interrelationships in the rat. The text also describes the melatonin and the endocrine role of the pineal organ; the integration of the secretory control mechanisms for insulin, glucagon, and growth hormone; and the biological activity of somatomedin. The chemistry and physiology of parathyroid hormone, calcitonin, and vitamin d; and the physicochemical properties and activities of luteinizing hormone and human chorionic gonadotropin are also encompassed. Endocrinologists, physiologists, and students taking related courses will find the book invaluable.

Table of Contents

List of Contributors


Recent Progress in Cyclic Nucleotide Research

I. Introduction

II. Adenylyl Cyclase

III. Cyclic Nucleotide Phosphodiesterases

IV. Mechanism of Action of Cyclic AMP

V. Cyclic GMP

VI. Summary


Hypothalamic Control of Anterior Pituitary Hormone Secretion—Characterized Hypothalamic-Hypophysiotropic Peptides

I. Introduction

II. Physiology of Hypothalamic-Releasing and Release-Inhibiting Factors Acting on the Anterior Pituitary

III. Mechanism of Action of Hypothalamic-Releasing Factors

IV. Peripheral Control of Pituitary Secretion

V. Thyrotropin-Releasing Factor ( T R F )

VI. Luteinizing Hormone-Releasing Factor ( L R F )

VII. Hypothalamic Control of Growth Hormone Secretion

VIII. Hypothalamic Control of Melanocyte-Stimulating Hormone (MSH)

IX. Concluding Remarks


Pituitary-Ovarian Interrelationships in the Rat

I. Introduction

II. Ovarian Regulation of Gonadotropin Secretion

III. Ovarian Regulation of Prolactin Secretion

IV. Regulation of Corpus Luteum Function


Melatonin and the Endocrine Role of the Pineal Organ

I. Introduction

II. Melatonin Biosynthesis

III. Melatonin Metabolism

IV. Melatonin and Pinealectomy-Induced Endocrine Changes

V. Other Possible Sources of Melatonin

VI. Conclusions


Integration of the Secretory Control Mechanisms for Insulin, Glucagon, and Growth Hormone

I. Introduction

II. Secretory Control Mechanisms

III. Mutual and Autoregulation of Secretion of the Three Hormones

IV. Metabolic Actions

V. Hormonal Response to Meals

VI. Hormonal Milieu in Altered Physiological and Pathological States

VII. Relative Importance of the Three Hormones in Metabolism

VIII. Concluding Remarks



I. Introduction

II. Bioassay of Somatomedin

III. Somatomedin Levels in Disorders of Growth

IV. Purification of Somatomedin

V. Biological Actions of Somatomedin in Vitro

VI. Relation between Somatomedin and Other Growth Factors

VII. Conclusions


Parathyroid Hormone, Calcitonin, and Vitamin D

I. Introduction

II. Parathyroid Hormone

III. Calcitonin

IV. Vitamin D


Luteinizing Hormone and Human Chorionic Gonadotropin: Structure and Activity

I. Luteinizing Hormone

II. Human Chorionic Gonadotropin


Subject Index


No. of pages:
© Academic Press 1974
Academic Press
eBook ISBN:

About the Editor

V. H. T. James

L Martini

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