Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528317, 9781483217307

Current Topics in Cellular Regulation, Volume 31

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman P. Boon Chock
eBook ISBN: 9781483217307
Imprint: Academic Press
Published Date: 28th September 1990
Page Count: 288
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Table of Contents


Calcium as Intracellular Messenger: From Simplicity to Complexity


I. Introduction


II. The Simplicity of Ca2+ as Messenger


III. Ca2+ and Cylic AMP as Synarchic Messengers


IV. Ca2+ Metabolism and Calcium Homeostasis During Sustained Cellular Responses


V. Ca2+ as Messenger in Sustained Cellular Responses


VI. Time-Dependent Changes in Cell Responsiveness


VII. The Complexity and Elegance of Ca2+ Messenger Generation, Readout, and Action


References


The Integration of Receptor-Regulated Intracellular Calcium Release and Calcium Entry Across the Plasma Membrane


I. Introduction


II. Sources of Activator Calcium


III. Mechanisms of Intracellular Calcium Release


IV. Mechanisms of Calcium Entry


V. Conclusions


References


The Role of Calcium in Neurotransmitter Release: Existing Models and New Approaches to Evaluate Possible Mechanisms


I. Introduction


II. Current Models of the Mechanism of Synaptic Release


III. Experimental Models and Techniques Applied to the Study of Secretion


IV. Role of Second Messengers in Exocytosis


V. Concluding Remarks


References


Regulation of Free Calmodulin Levels in Neurons by Neuromodulin: Relationship to Neuronal Growth and Regeneration


I. Discovery of Neuromodulin as a Calmodulin-Binding Protein


II. Distribution of Neuromodulin within Brain


III. Physical Properties of Neuromodulin


IV. Primary Amino Acid Sequence of Neuromodulin and Identification of Its Calmodulin-Binding Domain


V. Regulation of Calmodulin Binding to Neuromodulin by Protein Kinase C Phosphorylation and Calcineurin Dephosphorylation


VI. Cloning of cDNAs Encoding Neuromodulin and Expression of the P


Description

Current Topics in Cellular Regulation: Volume 31 is a collection of papers that deals with the role of calcium as intracellular messenger, calcium release or entry across the plasma membrane, calcium in neurotransmitter release, and the regulation of free calmodulin levels in neurons by neuromodulin. Other papers discuss the calcium/calmodulin-dependent protein kinase II, the regulation of muscular calcium channels, and the Na+-Ca2+ exchangers. One paper describes the mechanisms of intracellular calcium release or entry in which agonists acting through the phosphoinositide system, or possibly by metabolites or secondary messenger system,can regulate the mechanisms of cellular Ca2+. Another paper describes different approaches in evaluating the possible mechanisms of calcium in neurotransmitter release. The paper notes that imaging techniques can be used in the timing and order of events in the release process. Possible identification by the investigator of specific "releasing" regions at the membranes, such as active zones, can also define more precisely the exact localization of the process. One paper discusses the interaction between released calmodulin and cytoskeleton proteins that can affect polymerization and cross-linking of cytoskeleton polymers, that leads to filopodia formation or extension. The collection will prove beneficial to molecular biologists, general biologists, microbiologists, biochemists, and researchers involved in cellular biology.


Details

No. of pages:
288
Language:
English
Copyright:
© Academic Press 1990
Published:
Imprint:
Academic Press
eBook ISBN:
9781483217307

Ratings and Reviews


About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor

P. Boon Chock Editor