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Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528294, 9781483217284

Current Topics in Cellular Regulation, Volume 29

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217284
Imprint: Academic Press
Published Date: 28th May 1988
Page Count: 364
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Table of Contents

Control of Metabolism by Dynamic Macromolecular Interactions

I. Introduction

II. Control of Metabolic Pathways

III. Dynamically Organized Enzyme Systems

IV. Energetic Aspects

V. Concluding Remarks


Ligand Binding and Multienzyme Complex Formation Between Ornithine Carbamoyltransferase and Arginase from Saccharomyces cerevisiae

I. Introduction

II. Regulation of Arginine Metabolism in Saccharomyces cerevisiae

III. Quaternary Structure of Yeast OTCase and Arginase

IV. Quaternary Structure of the OTCase-Arginase Multienzyme Complex

V. Test for an Ornithine Isosteric Effector Site

VI. Intrinsic and Extrinsic Effects


Regulation of Fatty Acid Uptake and Synthesis in Mammary and Adipose Tissues: Contrasting Roles for Cyclic AMP

I. Introduction

II. The Cyclic AMP Economy of Mammary Tissue During Lactation

III. Acute Regulation of Fatty Acid Uptake and Biosynthesis Processes in Lactating Mammary Tissue

IV. Regulation of Acetyl-CoA Carboxylase

V. Cyclic AMP-Dependent Protein Phosphorylation in Mammary Epithelial Cells

VI. Concluding Remarks


Structural and Functional Relationships of Guanosine Triphosphate Binding Proteins

I. Introduction

II. The Role of Guanine Nucleotide Binding Proteins in Hormonal Regulation of Adenylate Cyclase Activity

III. The Role of Guanine Nucleotide Binding Proteins in Visual Signal Transmission

IV. Novel Guanine Nucleotide Binding Proteins with Other Functions, and Known Guanine Nucleotide Binding Proteins with Novel Functions

V. G Protein Structures

VI. Summary


The Glycogen Storage Disease (gsd/gsd) Rat

I. Introduction

II. The gsd/gsd Rat

III. Perinatal Development in the gsd/gsd Rat

IV. Ultrastructure and Morphometry

V. Metabolism in Aged gsd/gsd Rats

VI. Concluding Remarks



Function and Regulation of the Pentose Phosphate Pathway in Brain

I. Introduction

II. Measurement of the Pentose Phosphate Pathway

III. Contribution of the Pentose Phosphate Pathway to Glucose Metabolism

IV. Effects of Activators and Inhibitors on the Pentose Phosphate Pathway in Brain Preparations

V. Developmental Changes in the Activity of the Pentose Phosphate Pathway

VI. Functional Significance of the Pentose Phosphate Pathway in Brain

VII. Summary


Regulation of Carotenoid Biosynthesis

I. Introduction

II. Structure and Nomenclature

III. Biosynthetic Pathways and Carotenogenic Enzymes

IV. Genes Involved in Carotenoid Biosynthesis

V. Regulation of Carotenoid Biosynthesis

VI. Regulatory Genes

VII. Conclusions and Future Studies




Current Topics in Cellular Regulation: Volume 29 is a collection of papers that deals with dynamic macromolecular interactions, ligand binding, multi-enzyme complex formation, the regulation of fatty acid uptake, and synthesis in mammary or adipose tissues. Other papers explain the functional relationships of guanosine triphosphate binding proteins, the glycogen storage disease, the regulation of the pentose phosphate pathway in the brain, as well as the regulation of carotenoid biosynthesis. One paper discusses the dissociable enzyme complexes stabilized by weak interactions, particularly on the interaction of cytosolic enzymes with the contractile apparatus, with membranes, or with functionally related enzymes. Another paper investigates the mechanism of acute regulation, in mammary epithelial cells, of the processes which collaborate to supply fatty acids for esterification to form glycerolipids (which is predominantly triacylglycerol). Glycerolipids comprise mostly the total lipid content of the secretory product of those cells—mammalian milk. The paper notes that a counter-regulatory hormone collaborating with insulin in the regulation of lipid metabolism in the lactating mammary cell, does not act via cyclic AMP. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology or physiology.


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© Academic Press 1988
28th May 1988
Academic Press
eBook ISBN:

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About the Editors

Bernard L. Horecker

Earl R. Stadtman