Current Topics in Cellular Regulation

Current Topics in Cellular Regulation

1st Edition - May 28, 1988

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  • Editors: Bernard L. Horecker, Earl R. Stadtman
  • eBook ISBN: 9781483217284

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Current Topics in Cellular Regulation: Volume 29 is a collection of papers that deals with dynamic macromolecular interactions, ligand binding, multi-enzyme complex formation, the regulation of fatty acid uptake, and synthesis in mammary or adipose tissues. Other papers explain the functional relationships of guanosine triphosphate binding proteins, the glycogen storage disease, the regulation of the pentose phosphate pathway in the brain, as well as the regulation of carotenoid biosynthesis. One paper discusses the dissociable enzyme complexes stabilized by weak interactions, particularly on the interaction of cytosolic enzymes with the contractile apparatus, with membranes, or with functionally related enzymes. Another paper investigates the mechanism of acute regulation, in mammary epithelial cells, of the processes which collaborate to supply fatty acids for esterification to form glycerolipids (which is predominantly triacylglycerol). Glycerolipids comprise mostly the total lipid content of the secretory product of those cells—mammalian milk. The paper notes that a counter-regulatory hormone collaborating with insulin in the regulation of lipid metabolism in the lactating mammary cell, does not act via cyclic AMP. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology or physiology.

Table of Contents

  • Control of Metabolism by Dynamic Macromolecular Interactions

    I. Introduction

    II. Control of Metabolic Pathways

    III. Dynamically Organized Enzyme Systems

    IV. Energetic Aspects

    V. Concluding Remarks


    Ligand Binding and Multienzyme Complex Formation Between Ornithine Carbamoyltransferase and Arginase from Saccharomyces cerevisiae

    I. Introduction

    II. Regulation of Arginine Metabolism in Saccharomyces cerevisiae

    III. Quaternary Structure of Yeast OTCase and Arginase

    IV. Quaternary Structure of the OTCase-Arginase Multienzyme Complex

    V. Test for an Ornithine Isosteric Effector Site

    VI. Intrinsic and Extrinsic Effects


    Regulation of Fatty Acid Uptake and Synthesis in Mammary and Adipose Tissues: Contrasting Roles for Cyclic AMP

    I. Introduction

    II. The Cyclic AMP Economy of Mammary Tissue During Lactation

    III. Acute Regulation of Fatty Acid Uptake and Biosynthesis Processes in Lactating Mammary Tissue

    IV. Regulation of Acetyl-CoA Carboxylase

    V. Cyclic AMP-Dependent Protein Phosphorylation in Mammary Epithelial Cells

    VI. Concluding Remarks


    Structural and Functional Relationships of Guanosine Triphosphate Binding Proteins

    I. Introduction

    II. The Role of Guanine Nucleotide Binding Proteins in Hormonal Regulation of Adenylate Cyclase Activity

    III. The Role of Guanine Nucleotide Binding Proteins in Visual Signal Transmission

    IV. Novel Guanine Nucleotide Binding Proteins with Other Functions, and Known Guanine Nucleotide Binding Proteins with Novel Functions

    V. G Protein Structures

    VI. Summary


    The Glycogen Storage Disease (gsd/gsd) Rat

    I. Introduction

    II. The gsd/gsd Rat

    III. Perinatal Development in the gsd/gsd Rat

    IV. Ultrastructure and Morphometry

    V. Metabolism in Aged gsd/gsd Rats

    VI. Concluding Remarks



    Function and Regulation of the Pentose Phosphate Pathway in Brain

    I. Introduction

    II. Measurement of the Pentose Phosphate Pathway

    III. Contribution of the Pentose Phosphate Pathway to Glucose Metabolism

    IV. Effects of Activators and Inhibitors on the Pentose Phosphate Pathway in Brain Preparations

    V. Developmental Changes in the Activity of the Pentose Phosphate Pathway

    VI. Functional Significance of the Pentose Phosphate Pathway in Brain

    VII. Summary


    Regulation of Carotenoid Biosynthesis

    I. Introduction

    II. Structure and Nomenclature

    III. Biosynthetic Pathways and Carotenogenic Enzymes

    IV. Genes Involved in Carotenoid Biosynthesis

    V. Regulation of Carotenoid Biosynthesis

    VI. Regulatory Genes

    VII. Conclusions and Future Studies



Product details

  • No. of pages: 364
  • Language: English
  • Copyright: © Academic Press 1988
  • Published: May 28, 1988
  • Imprint: Academic Press
  • eBook ISBN: 9781483217284

About the Editors

Bernard L. Horecker

Earl R. Stadtman

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