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Enzyme-Enzyme Interactions and the Regulation of Metabolic Reaction Pathways
I. The Existence of Enzyme-Enzyme Interactions in Supermolecular Cellular Structures
II. The Concentration of Enzymes and Metabolites in Cellular Compartments and Their Influence on Metabolic Regulation
III. Evidence for the Direct Transfer of Metabolite Among Enzymes via Enzyme-Enzyme Interactions
IV. Molecular Inferences Regarding the Mechanism of Direct Transfer of Metabolites via Enzyme-Enzyme Interactions
V. Further Consequences of the Direct Transfer Mechanism on Metabolic Pathways
The Central Metabolic Pathways of Escherichia coli: Relationship Between Flux and Control at a Branch Point, Efficiency of Conversion to Biomass, and Excretion of Acetate
II. Flux of Carbon through the Central Metabolic Pathways
III. Control of Flux at the Junction Created During Growth on Acetate
IV. Excretion of Acetate and Conversion of Primary Carbon Source to Biomass
The Concept of the Intracellular Amino Acid Pool and Its Relevance in the Regulation of Protein Metabolism, with Particular Reference to Mammalian Cells
II. Intracellular Amino Acid Pools
III. Uptake Features of Amino Acids into the Intracellular Pools
IV. Pool Size and Composition
V. A General Perspective of Intracellular Amino Acid Pool
VI. Concluding Comments
Production of Superoxide by Phagocytic Leukocytes: A Paradigm for Stimulus-Response Phenomena
II. Overview of the Situation in Leukocytes
III. Reduction of Oxygen by Phagocytic Leukocytes
IV. Transmembrane Signaling
V. Conclusions and Future Considerations
Regulation of Adrenergic Receptor Function by Phosphorylation
II. Purification of Adrenergic Receptors
III. Regulation of Responsiveness: The Model of Desensitization
IV. Summary and Conclusions
Control of 5-Aminolevulinate Synthase in Animals
II. ALV-Synthase and Heme Biosynthesis
III. Mitochondrial and Cytosolic Forms of ALV-Synthase
IV. Control of the Catalytic Activity of ALV-Synthase
V. Transport of ALV-Synthase into Mitochondria
VI. Control of the Level of Hepatic ALV-Synthase
VII. Mechanism of Heme Depletion by Xenobiotics
VIII. Erythroid ALV-Synthase and Its Control
IX. ALV-Synthase Control in Other Tissues
X. Porphyrias and ALV-Synthase
Meprin: A Membrane-Bound Metallo-Endopeptidase
II. Molecular Properties and Cellular/Subcellular Distribution
III. Heritable Deficiency of Meprin Activity in Mice
IV. Physiological Significance of Meprin
Regulation of Intracellular Protein Turnover: Covalent Modification as a Mechanism of Marking Proteins for Degradation
III. Covalent Modification of Proteins as a First Step in the Degradation Process
IV. Mixed-Function Oxidation of Proteins
V. Characterization of a Nonlysosomal High-Molecular-Weight Cysteine Proteinase
VI. Basis for Susceptibility to Proteolysis
VII. Metabolic Control of Intracellular Protein Breakdown
VIII. Is ATP Required for the Degradation of All Proteins?
IX. Concluding Remarks
Current Topics in Cellular Regulation: Volume 28 is a collection of papers that deals with enzyme-enzyme interactions, regulation of metabolic reaction pathways, the relevance of intracellular amino acid pool in the regulation of protein metabolism, and the production of superoxide by phagocytic leukocytes. Other papers discuss the regulation of adrenergic receptor function by phosphyrylation, a membrane-bound metallo-endopeptidase (meprin), as well as the covalent modification as a mechanism of marking proteins for degradation. One paper notes that the transfer pathway involving enzyme-enzyme recognition is associated with molecular specificity features over those demanded by the molecular structural constraints of the individual enzyme sites. The Albery and Knowles principle, under certain conditions, shows that intermediary metabolites within a particular pathway exist in states of nearly equal free energy. One paper describes that the amino acid pool size and content are governed by the conditioning of intracellular proteins and the metabolic activity of the cell. The paper also suggests that intracellular pools do not regulate protein metabolism. The collection can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology or physiology.
- No. of pages:
- © Academic Press 1986
- 11th December 1986
- Academic Press
- eBook ISBN:
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