Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528287, 9781483217277

Current Topics in Cellular Regulation, Volume 28

1st Edition

A Practice Manual

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217277
Imprint: Academic Press
Published Date: 11th December 1986
Page Count: 358
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Table of Contents

Enzyme-Enzyme Interactions and the Regulation of Metabolic Reaction Pathways

I. The Existence of Enzyme-Enzyme Interactions in Supermolecular Cellular Structures

II. The Concentration of Enzymes and Metabolites in Cellular Compartments and Their Influence on Metabolic Regulation

III. Evidence for the Direct Transfer of Metabolite Among Enzymes via Enzyme-Enzyme Interactions

IV. Molecular Inferences Regarding the Mechanism of Direct Transfer of Metabolites via Enzyme-Enzyme Interactions

V. Further Consequences of the Direct Transfer Mechanism on Metabolic Pathways

VI. Conclusions


The Central Metabolic Pathways of Escherichia coli: Relationship Between Flux and Control at a Branch Point, Efficiency of Conversion to Biomass, and Excretion of Acetate

I. Overview

II. Flux of Carbon through the Central Metabolic Pathways

III. Control of Flux at the Junction Created During Growth on Acetate

IV. Excretion of Acetate and Conversion of Primary Carbon Source to Biomass


The Concept of the Intracellular Amino Acid Pool and Its Relevance in the Regulation of Protein Metabolism, with Particular Reference to Mammalian Cells

I. Introduction

II. Intracellular Amino Acid Pools

III. Uptake Features of Amino Acids into the Intracellular Pools

IV. Pool Size and Composition

V. A General Perspective of Intracellular Amino Acid Pool

VI. Concluding Comments


Production of Superoxide by Phagocytic Leukocytes: A Paradigm for Stimulus-Response Phenomena

I. Introduction

II. Overview of the Situation in Leukocytes

III. Reduction of Oxygen by Phagocytic Leukocytes

IV. Transmembrane Signaling

V. Conclusions and Future Considerations


Regulation of Adrenergic Receptor Function by Phosphorylation

I. Introduction

II. Purification of Adrenergic Receptors

III. Regulation of Responsiveness: The Model of Desensitization

IV. Summary and Conclusions


Control of 5-Aminolevulinate Synthase in Animals

I. Introduction

II. ALV-Synthase and Heme Biosynthesis

III. Mitochondrial and Cytosolic Forms of ALV-Synthase

IV. Control of the Catalytic Activity of ALV-Synthase

V. Transport of ALV-Synthase into Mitochondria

VI. Control of the Level of Hepatic ALV-Synthase

VII. Mechanism of Heme Depletion by Xenobiotics

VIII. Erythroid ALV-Synthase and Its Control

IX. ALV-Synthase Control in Other Tissues

X. Porphyrias and ALV-Synthase

XI. Summary


Meprin: A Membrane-Bound Metallo-Endopeptidase

I. Introduction

II. Molecular Properties and Cellular/Subcellular Distribution

III. Heritable Deficiency of Meprin Activity in Mice

IV. Physiological Significance of Meprin

V. Conclusions


Regulation of Intracellular Protein Turnover: Covalent Modification as a Mechanism of Marking Proteins for Degradation

I. Introduction

II. Background

III. Covalent Modification of Proteins as a First Step in the Degradation Process

IV. Mixed-Function Oxidation of Proteins

V. Characterization of a Nonlysosomal High-Molecular-Weight Cysteine Proteinase

VI. Basis for Susceptibility to Proteolysis

VII. Metabolic Control of Intracellular Protein Breakdown

VIII. Is ATP Required for the Degradation of All Proteins?

IX. Concluding Remarks




Current Topics in Cellular Regulation: Volume 28 is a collection of papers that deals with enzyme-enzyme interactions, regulation of metabolic reaction pathways, the relevance of intracellular amino acid pool in the regulation of protein metabolism, and the production of superoxide by phagocytic leukocytes. Other papers discuss the regulation of adrenergic receptor function by phosphyrylation, a membrane-bound metallo-endopeptidase (meprin), as well as the covalent modification as a mechanism of marking proteins for degradation. One paper notes that the transfer pathway involving enzyme-enzyme recognition is associated with molecular specificity features over those demanded by the molecular structural constraints of the individual enzyme sites. The Albery and Knowles principle, under certain conditions, shows that intermediary metabolites within a particular pathway exist in states of nearly equal free energy. One paper describes that the amino acid pool size and content are governed by the conditioning of intracellular proteins and the metabolic activity of the cell. The paper also suggests that intracellular pools do not regulate protein metabolism. The collection can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology or physiology.


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© Academic Press 1986
Academic Press
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About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor