Current Topics in Cellular Regulation

Current Topics in Cellular Regulation

A Practice Manual

1st Edition - December 11, 1986

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  • Editors: Bernard L. Horecker, Earl R. Stadtman
  • eBook ISBN: 9781483217277

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Current Topics in Cellular Regulation: Volume 28 is a collection of papers that deals with enzyme-enzyme interactions, regulation of metabolic reaction pathways, the relevance of intracellular amino acid pool in the regulation of protein metabolism, and the production of superoxide by phagocytic leukocytes. Other papers discuss the regulation of adrenergic receptor function by phosphyrylation, a membrane-bound metallo-endopeptidase (meprin), as well as the covalent modification as a mechanism of marking proteins for degradation. One paper notes that the transfer pathway involving enzyme-enzyme recognition is associated with molecular specificity features over those demanded by the molecular structural constraints of the individual enzyme sites. The Albery and Knowles principle, under certain conditions, shows that intermediary metabolites within a particular pathway exist in states of nearly equal free energy. One paper describes that the amino acid pool size and content are governed by the conditioning of intracellular proteins and the metabolic activity of the cell. The paper also suggests that intracellular pools do not regulate protein metabolism. The collection can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology or physiology.

Table of Contents

  • Enzyme-Enzyme Interactions and the Regulation of Metabolic Reaction Pathways

    I. The Existence of Enzyme-Enzyme Interactions in Supermolecular Cellular Structures

    II. The Concentration of Enzymes and Metabolites in Cellular Compartments and Their Influence on Metabolic Regulation

    III. Evidence for the Direct Transfer of Metabolite Among Enzymes via Enzyme-Enzyme Interactions

    IV. Molecular Inferences Regarding the Mechanism of Direct Transfer of Metabolites via Enzyme-Enzyme Interactions

    V. Further Consequences of the Direct Transfer Mechanism on Metabolic Pathways

    VI. Conclusions


    The Central Metabolic Pathways of Escherichia coli: Relationship Between Flux and Control at a Branch Point, Efficiency of Conversion to Biomass, and Excretion of Acetate

    I. Overview

    II. Flux of Carbon through the Central Metabolic Pathways

    III. Control of Flux at the Junction Created During Growth on Acetate

    IV. Excretion of Acetate and Conversion of Primary Carbon Source to Biomass


    The Concept of the Intracellular Amino Acid Pool and Its Relevance in the Regulation of Protein Metabolism, with Particular Reference to Mammalian Cells

    I. Introduction

    II. Intracellular Amino Acid Pools

    III. Uptake Features of Amino Acids into the Intracellular Pools

    IV. Pool Size and Composition

    V. A General Perspective of Intracellular Amino Acid Pool

    VI. Concluding Comments


    Production of Superoxide by Phagocytic Leukocytes: A Paradigm for Stimulus-Response Phenomena

    I. Introduction

    II. Overview of the Situation in Leukocytes

    III. Reduction of Oxygen by Phagocytic Leukocytes

    IV. Transmembrane Signaling

    V. Conclusions and Future Considerations


    Regulation of Adrenergic Receptor Function by Phosphorylation

    I. Introduction

    II. Purification of Adrenergic Receptors

    III. Regulation of Responsiveness: The Model of Desensitization

    IV. Summary and Conclusions


    Control of 5-Aminolevulinate Synthase in Animals

    I. Introduction

    II. ALV-Synthase and Heme Biosynthesis

    III. Mitochondrial and Cytosolic Forms of ALV-Synthase

    IV. Control of the Catalytic Activity of ALV-Synthase

    V. Transport of ALV-Synthase into Mitochondria

    VI. Control of the Level of Hepatic ALV-Synthase

    VII. Mechanism of Heme Depletion by Xenobiotics

    VIII. Erythroid ALV-Synthase and Its Control

    IX. ALV-Synthase Control in Other Tissues

    X. Porphyrias and ALV-Synthase

    XI. Summary


    Meprin: A Membrane-Bound Metallo-Endopeptidase

    I. Introduction

    II. Molecular Properties and Cellular/Subcellular Distribution

    III. Heritable Deficiency of Meprin Activity in Mice

    IV. Physiological Significance of Meprin

    V. Conclusions


    Regulation of Intracellular Protein Turnover: Covalent Modification as a Mechanism of Marking Proteins for Degradation

    I. Introduction

    II. Background

    III. Covalent Modification of Proteins as a First Step in the Degradation Process

    IV. Mixed-Function Oxidation of Proteins

    V. Characterization of a Nonlysosomal High-Molecular-Weight Cysteine Proteinase

    VI. Basis for Susceptibility to Proteolysis

    VII. Metabolic Control of Intracellular Protein Breakdown

    VIII. Is ATP Required for the Degradation of All Proteins?

    IX. Concluding Remarks



Product details

  • No. of pages: 358
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: December 11, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9781483217277

About the Editors

Bernard L. Horecker

Earl R. Stadtman

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