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List of Contributors
Roles of Eukaryotic Initiation Factor 2 Ancillary Factors in the Regulation of Eukaryotic Protein Synthesis Initiation
VI. eIF-2 Kinases
VIII. A Proposed Mechanism for Regulation of the Early Steps in Peptide Chain Initiation in Reticulocyte Lysates by eIF-2 Ancillary Factors
IX. Concluding Remarks
The Role of Phosphorylation in the Regulation of Eukaryotic Initiation Factor 2 Activity
II. Translational Control in Rabbit Reticulocyte Lysate
III. Phosphorylation State of eIF-2
IV. Is Ternary Complex Formation the Only Initiation Step Affected in Hemin-Deficient Lysate?
V. Other Modifications of eIF-2 Which Provide Insights into the Regulation of Its Activity
VI. Role of Phosphorylation in the Regulation of eIF-2 Activity
Probing the Function of the Eukaryotic 5′-Cap Structure Using Monoclonal Antibodies to Cap-Binding Proteins
II. Monoclonal Antibodies to Cap-Binding Proteins
III. Reaction of Monoclonal Antibodies with High-Molecular-Weight Proteins Antigenically Related to the 24-Cap-Binding Protein
IV. ATP-Mg2+-Dependent Cross-Linking of Cap-Binding Proteins to mRNA
V. Effect of Anti-Cap-Binding Protein Monoclonal Antibodies on Protein Synthesis
VI. Cap-Binding Proteins and the Cytoskeleton
Criteria for Establishment of the Biological Significance of Ribosomal Protein Phosphorylation
III. Changes in Vivo
IV. Signaling Systems
V. Reconstruction in Vitro
Casein Kinases—Multipotential Protein Kinases
II. Physicochemical Characterization
III. Substrate Specificity
IV. Comparison with Casein Kinases from Mammary Gland
VI. Phosphorylation of Endogenous Proteins
VII. Criteria for Classification of Casein Kinases
II. Multiple Forms and Substrate Specificity of Phosphoprotein Phosphatases
III. Purification and Properties of the Mr = 35,000 Phosphoprotein Phosphatases
IV. Relationship Between Phosphoprotein Phosphatases and Alkaline Phosphatases
V. Heat-Stable Protein Effectors
VI. High-Molecular-Weight Forms of Type I Phosphoprotein Phosphatase
VII. Regulation of Phosphoprotein Phosphatases
Note Added in Proof
I. Mono(ADP-Ribosyl)ation and Poly(ADP-Ribosyl)ation
II. Poly(ADP-Ribosyl)ation Reactions in Vitro
III. Poly(ADP-Ribosyl)ation and DNA Repair
Commitment to Terminal Differentiation and the Cell Cycle
II. Induced Commitment to Terminal Erythroid Differentiation
III. Characteristics of the Commitment Process
IV. Inducer Effects in Relation to the Cell Division Cycle
V. Relation of the Cell Cycle to the Replication of α- and β-Globin DNA Sequences in Erythroleukemia Cells
The Turnover Characteristics of Lactate Dehydrogenase
II. Methodological Considerations
III. Isozyme Turnover
IV. Physiological Variations
V. Biodegradation and Its Regulation
VI. Concluding Comments
The Role of Urea Synthesis in the Removal of Metabolic Bicarbonate and the Regulation of Blood pH
II. The Problem: Need for Disposal of HCO3-
III. The Solution: Acquisition of Proton from NH4+
IV. The Role of the Kidney
VIII. Appendix A: Equations for Relevant Catabolic Reactions or Processes
IX. Appendix B: Necessity for Disposal of HCO3-
Contents of Previous Volumes
Current Topics in Cellular Regulation, Volume 21 examines the advances in the general area of cellular regulation.
This book discusses the roles of eukaryotic initiation factor 2 ancillary factors in the regulation of eukaryotic protein synthesis initiation and phosphorylation state of eIF-2. The monoclonal antibodies to cap-binding proteins, criteria for establishment of the biological significance of ribosomal protein phosphorylation, and comparison with casein kinases from mammary gland are also elaborated. This text likewise covers the regulation of phosphoprotein phosphatases, poly(ADP-ribosyl)ation reactions in vitro, and induced commitment to terminal erythroid differentiation. Other topics include the turnover characteristics of lactate dehydrogenase and role of urea synthesis in the removal of metabolic bicarbonate and regulation of blood pH.
This volume is useful to biologists and researchers interested in basic mechanisms involved in the regulation of diverse cellular activities.
- No. of pages:
- © Academic Press 1982
- 28th July 1982
- Academic Press
- eBook ISBN:
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