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Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528195, 9781483217185

Current Topics in Cellular Regulation, Volume 19

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217185
Imprint: Academic Press
Published Date: 28th October 1981
Page Count: 334
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Table of Contents

List of Contributors

Regulation of the Histidine Operon: Translation-Controlled Transcription Termination (A Mechanism Common to Several Biosynthetic Operons)

I. Introduction

II. Histidine Biosynthesis: The Reaction, the Enzymes

III. Genetics

IV. Evidence Indicating That Synthesis of the Histidine Enzymes Is Regulated

V. Regulation

VI. Conclusions


Regulation of Ribonucleotide Reductase

I. Introduction

II. Structure of Enzymes

III. Hydrogen Transport Mechanism

IV. Allosteric Control

V. Regulation of Enzyme Synthesis

VI. Ribonucleotide Reductase and Regulation of DNA Synthesis

VII. Drugs Affecting Ribonucleotide Reductase

VIII. Ribonucleotide Reductase and Immune Dysfunction


Multimodulation of Enzyme Activity

I. Introduction

II. Mechanisms of Modulation of Enzyme Activity

III. Prototypes of Multimodulated Enzymes

IV. Multimodulated Enzymes with Three or More Regulatory Mechanisms

V. Analogy Principle in Comparative Biochemistry of Allosteric Regulation of Metabolism

VI. Extension of the Classification of Enzymes to Include Regulatory Mechanisms

VII. Evolutionary Origin of the Modulation of Enzyme Activity

VIII. Concluding Remarks


Kinetic Models of Metabolism in Intact Cells, Tissues, and Organisms

I. Introduction

II. Analysis of Systems in Steady State

III. Steady-State Model of the Citric Acid Cycle in Rat Liver

IV. Steady-State Model of Glucose Metabolism in Adipose Tissue

V. Analysis of Systems in Transition State

VI. Transition Models of Carbohydrate Metabolism in Dictyostelium

VII. Summary and Conclusions

VIII. Appendix: Comparison of Model Values and Data from Dictyostelium


In Vivo Functioning of the Na+, K+-Activated ATPase

I. Introduction

II. General Operative Considerations

III. Intrinsic Events: Properties of Binding Loci

IV. Significance of Intrinsic Parameters

V. Sensitivity of Enzyme Activity to Changing Ion Concentrations

VI. Extrinsic Events

VII. Processes Altering Enzyme Kinetics

VIII. Periodic Alterations

IX. Aperiodic Alterations

X. Activation Profile


Cyclic AMP-Dependent and Cyclic GMP-Dependent Protein Kinases of Nervous Tissue

I. Introduction

II. Structure and Properties of cAMP-Dependent and cGMP-Dependent Protein Kinases

III. cAMP-Dependent Protein Kinases of Nervous Tissue

IV. cGMP-Dependent Protein Kinase of Nervous Tissue

V. Concluding Remarks


The Insulin-Like Growth Factors (IGF) of Human Serum: Chemical and Biological Characterization and Aspects of Their Possible Physiological Role

I. Introduction: From Nonsuppressible Insulin-Like Activity (NSILA) to the Insulin-Like Growth Factors (IGF)

II. Purification of IGF I and II

III. Amino Acid Sequences of IGF I and II

IV. Phylogenetic Implications of the Sequence Homologies Between IGF, Proinsulin, and Insulin

V. Model of Three-Dimensional Structure of IGF

VI. Biological Effects of IGFs and Their Relationship to Receptor Binding

VII. The IGF Carrier Complex and Large-Molecular-Weight NSILA, the Native Forms of NSILA in Blood: Chemical and Biological Properties and Speculations on the Physiology of Native IGF

VIII. Relationship Between IGF and the Somatomedins

IX. Assays for the Determination of IGF in Biological Fluids and Cross-Reactions with Somatomedins

X. Site of Production of IGF

XI. Questions and Outlook



Contents of Previous Volumes


Current Topics in Cellular Regulation, Volume 19 analyzes the advances in the general area of cellular regulation.

This book discusses the evidence indicating that synthesis of the histidine enzymes is regulated and drugs affecting ribonucleotide reductase. The analogy principle in comparative biochemistry of allosteric regulation of metabolism, steady-state model of glucose metabolism in adipose tissue, and sensitivity of enzyme activity to changing ion concentrations are also elaborated. This publication likewise covers the cAMP-dependent protein kinases of nervous tissue and amino acid sequences of IGF I and II.

This volume is a good reference for biologists and researchers conducting work on the basic mechanisms involved in the regulation of diverse cellular activities.


No. of pages:
© Academic Press 1981
28th October 1981
Academic Press
eBook ISBN:

Ratings and Reviews

About the Editors

Bernard L. Horecker

Earl R. Stadtman