Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528164, 9781483217154

Current Topics in Cellular Regulation, Volume 16

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217154
Imprint: Academic Press
Published Date: 28th June 1980
Page Count: 332
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Table of Contents

List of Contributors

Brain Hexokinase, the Prototype Ambiquitous Enzyme

I. Introduction

II. Subcellular Distribution of Hexokinase in Brain Homogenates

III. Cytoplasmic and Mitochondrial Forms of Brain Hexokinase

IV. Mitochondrial Hexokinase

V. Ambiquitous Behavior of Brain Hexokinase

VI. The Molecular Basis for the Specific Binding of Brain Hexokinase by the Outer Mitochondrial Membrane

VII. Hexokinase Activity as a Reflection of Glycolytic Capacity

VIII. Concluding Comments


Appendix: Ambiquitous Behavior—A Biological Phenomenon of General Significance?

Appendix References

Compartmentation of Hexokinase and Creatine Phosphokinase, Cellular Regulation, and Insulin Action

I. Introduction

II. Experimental Evidence for Bound Hexokinase as a Compartmental Control Point

III. Bound Creatine Phosphokinase: Experimental Evidence for Compartmentation

IV. The Hexokinase-Mitochondrial Theory of Insulin Action and Hormonal Metabolic Control


Cytochrome c Methylation: Enzymology and Biologic Significance

I. Opening Remarks on Protein Methylation

II. Cytochrome c Methylation

III. Closing Remarks


Enzyme Organization in the Polyaromatic-Biosynthetic Pathway: The Arom Conjugate and Other Multienzyme Systems

I. Introduction

II. The Polyaromatic-Biosynthetic Multienzyme System

III. Phylogenetic Aspects of Enzyme Organization in the Polyaromatic Pathway

IV. Concluding Remarks

Appendix: Enzyme Organization in Vivo: Some Thermodynamic-Kinetic Perspectives


Proteolysis in Bacterial Sporulation

I. Introduction



Current Topics in Cellular Regulation, Volume 16 considers the advances in the general area of cellular regulation.

This book discusses the subcellular distribution of hexokinase in brain homogenates and experimental evidence for bound hexokinase as a compartmental control point. The enzymology and biologic significance of cytochrome c methylation, polyaromatic-biosynthetic multienzyme system, and proteolytic modulation of gene expression in sporulation are also elaborated. This text likewise covers the occurrence of cyclic nucleotide-synthesizing and -degrading enzymes in the mammalian brain and calcium ion as a positive effector of oocyte maturation.

This volume is beneficial to biologists and researchers conducting work on the basic mechanisms involved in the regulation of diverse cellular activities.


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© Academic Press 1980
Academic Press
eBook ISBN:

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About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor