Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528126, 9781483217116

Current Topics in Cellular Regulation, Volume 12

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217116
Imprint: Academic Press
Published Date: 28th May 1977
Page Count: 292
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Table of Contents


Contents


List of Contributors


Preface


Preface to Volume 12


Hormone Receptors as Regulators of Hormone Action


I. Introduction


II. The Elements of the Hormonal Response


III. Regulation of the Hormonal Response


IV. Mechanism of the Hormonal Response


V. Summary


References


Soluble Cyclic AMP-Dependent Protein Kinases: Review of the Enzyme Isolated from Bovine Cardiac Muscle


I. Introduction


II. Protein Kinases


III. Bovine Cardiac Muscle Protein Kinase


IV. Speculation


References


Metabolic Control and the Microenvironment


I. Introduction


II. Classical Concepts of Control


III. Realities of the Microenvironment


IV. A Case for New Concepts and Considerations


V. Areas of Metabolism Influenced by Fructose Diphosphate


VI. Concluding Remarks


List of Abbreviations


References


The Role of Compartmentation in the Control of Glycolysis


I. Introduction


II. Indirect Evidence of Localization


III. Theoretical Considerations


IV. Studies on Individual Enzymes of Glycolysis


V. Compartmentation of Metabolites


VI. Pyruvate


VII. Compartmentation Between Organs in Complex Animals


VIII. The Uncontrollability of Glycolysis


List of Abbreviations


References


The Evolution of Induction Mechanisms in Bacteria: Insights Derived from the Study of the β-Ketoadipate Pathway


I. Introduction


II. Induction Mechanisms


III. Origins of Regulatory Genes


IV. The β-Ketoadipate Pathway


V. Economy of Enzyme Synthesis


VI. Unified Induction


VII. Genet


Description

Current Topics in Cellular Regulation, Volume 12 focuses on the binding of polypeptide hormones to the specific receptor sites on the cellular membrane.

This book consists of six chapters. Chapter 1 describes how several polypeptide regulators, hormones, and growth factors act through very similar mechanisms. The second messenger roles of cAMP and cGMP in the regulation of various protein kinases are dealt with in Chapter 2. Chapter 3 discusses the experimental conditions employed in studying the characteristics of regulatory enzymes in vitro and in vivo, while Chapter 4 elaborates the intracellular compartmentation of enzymes, cofactors, and metabolic intermediates of glycolysis in various tissues from different organisms. The biochemical mechanisms that underlie the induction of enzymes in catabolic pathways are considered in Chapter 5. The last chapter is devoted to the role of T4 phage-induced covalent modification reactions in the transcriptional control of DNA-dependent RNA-polymerase in E. coli.

This volume is suitable for biologists and researchers concerned with the basic mechanisms involved in the regulation of diverse cellular activities.


Details

No. of pages:
292
Language:
English
Copyright:
© Academic Press 1977
Published:
Imprint:
Academic Press
eBook ISBN:
9781483217116

Ratings and Reviews


About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor