Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528102, 9781483217093

Current Topics in Cellular Regulation, Volume 10

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217093
Imprint: Academic Press
Published Date: 28th March 1976
Page Count: 312
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Table of Contents


List of Contributors


Preface


Preface to Volume 10


Contents of Previous Volumes


The Role of Negative Cooperativity and Half-of-the-Sites Reactivity in Enzyme Regulation


I. Introduction


II. Theoretical


III. Negatively Cooperative Enzymes—Examples


IV. Mixed Negative-Positive Cooperativity


V. Half-of-the-Sites Reactivity


VI. Enzymes with Half-of-the-Sites Reactivity


VII. Evaluation of Negative Cooperativity and Half-of-the-Sites Reactivity


VIII. The Biological Significance of Negative Cooperativity


References


Signal Transfer from Hormone Receptor to Adenylate Cyclase


I. Introduction


II. Hormone-Receptor Interactions


III. Adenylate Cyclase


IV. Coupling Between Receptor and Adenylate Cyclase


V. Concluding Remarks


References


Addendum


References for Addendum


Regulation of the Glycogen Phosphorylase System—From Physical Measurements to Biological Speculations


I. Introduction


II. The Phosphorylase Cascade System


III. The Individual Components of the Cascade System


IV. The Methods


V. Effects of Ligands on Phosphorylase


VI. Heterotropic Interactions of Phosphorylase b


VII. The Relation Between Ligand and Probe Binding Sites


VIII. The Phosphorylase b to a Conversion


IX. Protein-Glycogen Complexes—An Approach to the in Vivo Situation


X. The Control of Phosphorylase Activity in Vivo


XI. Conclusion


References


Citrate Synthase


I. Introduction


II. Molecular Properties


III. Ionic Effects


IV. Regulation of Activity—The in Vitro Behavior


V. Regulation of


Description

Current Topics in Cellular Regulation, Volume 10 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.

Organized into six chapters, this volume begins with an overview of the enzymes that exhibit half-of-the-sites activity. This text then examines the two different aspects of cyclic AMP-mediated systems. Other chapters consider the possible role of citrate synthase in the regulation of the citric acid cycle. This book discusses as well the regulation of the pentose phosphate pathway. The final chapter reviews the evidence for the occurrence of futile cycles at three control points in the metabolism of glucose, namely, at the level of glucose phosphorylation, at the interconversion of fructose mono- and biophosphates, and between pyruvate and phosphenol pyruvate.

This book is a valuable resource for biochemists, biologists, and research workers.


Details

No. of pages:
312
Language:
English
Copyright:
© Academic Press 1976
Published:
Imprint:
Academic Press
eBook ISBN:
9781483217093

Ratings and Reviews


About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor