Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528089, 9781483217079

Current Topics in Cellular Regulation, Volume 8

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217079
Imprint: Academic Press
Published Date: 28th September 1974
Page Count: 370
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Table of Contents

List of Contributors


Preface to Volume 8

Contents of Previous Volumes

A Molecular Model for Morphogenesis: The Primary Septum of Yeast

I. The Biological Problem

II. The Model

III. The Enzymatic Mechanism of Chitin Synthesis

IV. Intracellular Distribution of the Components of the Chitin Synthetase System

V. A Working Hypothesis for Septum Initiation

VI. Some Final Comments


Metabolic Regulation by Multifunctional Glucose-6-Phosphatase

I. Introduction

II. Multifunctionality and Other Characteristics of the Enzyme

III. Is Phosphotransferase Activity of Glucose-6-Phosphatase of Physiological Significance?

IV. Control of Hydrolytic and Synthetic Activities of Glucose-6-phosphatase-Phosphotransferase

V. Some Proposed Physiological Regulatory Roles for Synthetic and Hydrolytic Activities of Glucose-6-phosphatase-Phosphotransferase

VI. A Concluding Statement



Glutamine Synthetase as a Regulator of Enzyme Synthesis

I. Introduction

II. Genetics of Glutamine Synthetase

III. Glutamine Synthetase as Repressor of Glutamate Dehydrogenase

IV. Glutamine Synthetase as Activator of the Synthesis of Enzymes Forming Glutamate from Amino Acids

V. Conclusions


Acetyl Coenzyme A Carboxylase

I. Background

II. Molecular Properties

III. Mechanism of the Reaction and Prosthetic Group Translocation

IV. Regulation of Catalytic Activity

V. Concluding Remarks


Regulation of Lipogenesis in Animal Tissues

I. Introduction

II. Regulation of the Enzymes Involved in Fatty Acid Synthesis

III. Regulation of Fatty Acid Esterification


Deamidation of Glutaminyl and Asparaginyl Residues in Peptides and Proteins

I. Introduction

II. Deamidation Half-Times of Glutaminyl and Asparaginyl Residues in Peptides

III. Deamidation of Glutaminyl and Asparaginyl Residues in Proteins

IV. Special Intramolecular and Intermolecular Effects

V. Molecular Clocks

VI. Summary


Pasteur Effect and Phosphofructokinase

I. Introduction

II. Definition and Physiological Importance

III. Methods for Demonstrating the Pasteur Effect

IV. Inhibitors of the Pasteur Effect

V. Mechanism of the Pasteur Effect

VI. Phosphofructokinase as the Site of the Pasteur Effect

VII. Properties of Phosphofructokinase and Their Relation to the Pasteur Effect in the Cell

VIII. Analysis of the Multiplicity of Effectors of Phosphofructokinase

IX. Systems in Which the Pasteur Effect Is Absent

X. Molecular Properties of Phosphofructokinase and the Mechanism of Action of Effectors

XI. Specificity of Effectors and Substrates of Phosphofructokinase

XII. Sedoheptulose 7-Phosphate Kinase Activity of Phosphofructokinase

XIII. Conclusions


Subject Index


Current Topics in Cellular Regulation, Volume 8 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.

Organized into seven chapters, this volume begins with an overview of the roles of multiple protein factors in the conversion of chitin synthetase zymogen to its catalytically active form. This text then examines the mechanisms that underlie differential metabolic control of the diverse functions of glucose-6-phosphatase. Other chapters consider the results of studies in Klebsiella aerogenes. This book discusses as well the physical–chemical properties of the enzymes from animals and bacteria. The final chapter deals with the mechanisms of regulating lipogenesis in animal tissues, the deamidation of glutamyl and asparaginyl residues in peptides and proteins.

This book is a valuable resource for biochemists, biologists, and research workers.


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© Academic Press 1974
Academic Press
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About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor