Current Topics in Cellular Regulation

List of Contributors

Preface

Preface to Volume 8

Contents of Previous Volumes

A Molecular Model for Morphogenesis: The Primary Septum of Yeast

I. The Biological Problem

II. The Model

III. The Enzymatic Mechanism of Chitin Synthesis

IV. Intracellular Distribution of the Components of the Chitin Synthetase System

V. A Working Hypothesis for Septum Initiation

VI. Some Final Comments

References

Metabolic Regulation by Multifunctional Glucose-6-Phosphatase

I. Introduction

II. Multifunctionality and Other Characteristics of the Enzyme

III. Is Phosphotransferase Activity of Glucose-6-Phosphatase of Physiological Significance?

IV. Control of Hydrolytic and Synthetic Activities of Glucose-6-phosphatase-Phosphotransferase

V. Some Proposed Physiological Regulatory Roles for Synthetic and Hydrolytic Activities of Glucose-6-phosphatase-Phosphotransferase

VI. A Concluding Statement

Appendix

References

Glutamine Synthetase as a Regulator of Enzyme Synthesis

I. Introduction

II. Genetics of Glutamine Synthetase

III. Glutamine Synthetase as Repressor of Glutamate Dehydrogenase

IV. Glutamine Synthetase as Activator of the Synthesis of Enzymes Forming Glutamate from Amino Acids

V. Conclusions

References

Acetyl Coenzyme A Carboxylase

I. Background

II. Molecular Properties

III. Mechanism of the Reaction and Prosthetic Group Translocation

IV. Regulation of Catalytic Activity

V. Concluding Remarks

References

Regulation of Lipogenesis in Animal Tissues

I. Introduction

II. Regulation of the Enzymes Involved in Fatty Acid Synthesis

III. Regulation of Fatty Acid Esterification

References

Deamidation of Glutaminyl and Asparaginyl Residues in Peptides and Proteins

I. Introduction

II. Deamidation Half-Times of Glutaminyl and Asparaginyl Residues in Peptides

III. Deamidation of Glutaminyl and Asparaginyl Residues in Proteins

IV. Special Intramolecular and Intermolecular Effects

V. Molecular Clocks

VI. Summary

References

Pasteur Effect and Phosphofructokinase

I. Introduction

II. Definition and Physiological Importance

III. Methods for Demonstrating the Pasteur Effect

IV. Inhibitors of the Pasteur Effect

V. Mechanism of the Pasteur Effect

VI. Phosphofructokinase as the Site of the Pasteur Effect

VII. Properties of Phosphofructokinase and Their Relation to the Pasteur Effect in the Cell

VIII. Analysis of the Multiplicity of Effectors of Phosphofructokinase

IX. Systems in Which the Pasteur Effect Is Absent

X. Molecular Properties of Phosphofructokinase and the Mechanism of Action of Effectors

XI. Specificity of Effectors and Substrates of Phosphofructokinase

XII. Sedoheptulose 7-Phosphate Kinase Activity of Phosphofructokinase

XIII. Conclusions

References

Subject Index