Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528058, 9781483217048

Current Topics in Cellular Regulation, Volume 5

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217048
Imprint: Academic Press
Published Date: 28th July 1972
Page Count: 348
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Table of Contents

List of Contributors


Contents of Previous Volumes


I. Introduction—The Discovery of the Regulatory Role of Phosphofructokinase

II. Molecular Structure and Association-Dissociation Systems

III. Allosteric Kinetics

IV. Nature of Allosteric Control

V. Identification of Functional Groups in the Enzyme

VI. Mechanism of the Reaction

VII. Physiological Interpretation of Phosphofructokinase Regulation

VIII. Complementarity in Enzyme Regulation

IX. Conclusion


A Theoretical Background to the Use of Measured Concentrations of Intermediates in Study of the Control of Intermediary Metabolism

I. Introduction

II. Theoretical Background to the Study of Intermediary Metabolism and a General Approach

III. The Crossover Theorem

IV. Application of the Principles Developed


Memory Molecules

I. Introduction

II. Historical Review: Approaches Used by Chemists, Anatomists, Pharmacologists, and Neurophysiologists

III. In Search of the Engram

IV. Nucleoproteins Increased with Brain Activity

V. RNA as the Memory Molecule

VI. Short-Term and Long-Term Memory: Proteins for Coding?

VII. Interanimal Transfer of Acquired Information

VIII. Scotophobin: First Deciphered Word of a New Biological Code?

IX. A Theory for the Mode of Action of Memory Peptides

X. Conclusion


Protein Kinases

I. Introduction

II. General Aspects

III. Protein Kinases and the Regulation of Glycogen Metabolism

IV. Cyclic AMP-Dependent Protein Kinases

V. Protein Kinases and the Regulation of Lipid Metabolism

VI. Protein Kinases and the Regulation of Nuclear Activity

VII. The Regulation of Adrenal Steroid Production

VIII. Protein Kinases and the Regulation of Pyruvic Dehydrogenase

IX. Protein Kinases and the Regulation of Other Systems


Glutamine Phosphoribosylpyrophosphate Amidotransferase

I. Introduction

II. Kinetics and Mechanism of Action

III. Structure

IV. Regulation of Activity

V. Enzyme Induction, Derepression, and Repression

VI. Summary


The Regulatory Influence of Allosteric Effectors on Deoxycytidylate Deaminases

I. Introduction

II. Feedback Regulation of Deoxycytidylate Deaminase

III. Allosteric Transitions Effected by the Regulatory Ligands

IV. Active and Inactive States Associated with Deoxycytidylate Deaminase

V. Use of Inhibitors to Define the Physiological Significance of Deoxycytidylate Deaminase

VI. Distribution and Role Deoxycytidylate Deaminase in Bacterial Systems

VII. Regulatory Responses of the Bacteriophage-Induced Deoxycytidylate Deaminases to Its Metabolic End Products

VIII. Physical and Chemical Properties of the T2r* Bacteriophage-Induced Deoxycytidylate Deaminase

IX. The Effect of pH on the Allosteric Response of Deoxycytidylate Deaminase

X. Studies on the in Vitro Synthesis of Bacteriophage-Induced Deoxycytidylate Deaminase

IX . Conclusion


The Citrate Enzymes: Their Structures. Mechanisms. and Biological Functions

I. Introduction

II. Citrate Lyase (Citritase)

III. Citrate Synthase

IV. ATP Citrate Lyase (Citrate Cleavage Enzyme)

V. Overview


Regulation of Histidine Biosynthesis in Salmonella typhimurium

I. Introduction

II. The Enzymes of Histidine Biosynthesis

III. The Operon

IV. Feedback Inhibition

V. Repression

VI. Other Possible Mechanisms of Regulation


Author Index

Subject Index


Current Topics in Cellular Regulation, Volume 5 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.

Organized into eight chapters, this volume begins with an overview of the role of phosphofructokinase in the regulation of glycolysis. This text then outlines the structural aspects of phosphofructokinase, its main kinetic properties, and the various mechanisms that have been proposed for its regulation. Other chapters consider the four-stage approach to analysis of control mechanisms. This book discusses as well the regulation of cellular function through the mechanism of protein phosphorylation. The final chapter deals with the pathway for histidine biosynthesis in Salmonella typhimurium, which consists of a series of reactions, each catalyzed by a specific enzyme.

This book is a valuable resource for biologists and biochemists.


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© Academic Press 1972
Academic Press
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About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor