Current Topics in Cellular Regulation

List of Contributors

Preface

Contents of Previous Volumes

Phosphofructokinase

I. Introduction—The Discovery of the Regulatory Role of Phosphofructokinase

II. Molecular Structure and Association-Dissociation Systems

III. Allosteric Kinetics

IV. Nature of Allosteric Control

V. Identification of Functional Groups in the Enzyme

VI. Mechanism of the Reaction

VII. Physiological Interpretation of Phosphofructokinase Regulation

VIII. Complementarity in Enzyme Regulation

IX. Conclusion

References

A Theoretical Background to the Use of Measured Concentrations of Intermediates in Study of the Control of Intermediary Metabolism

I. Introduction

II. Theoretical Background to the Study of Intermediary Metabolism and a General Approach

III. The Crossover Theorem

IV. Application of the Principles Developed

References

Memory Molecules

I. Introduction

II. Historical Review: Approaches Used by Chemists, Anatomists, Pharmacologists, and Neurophysiologists

III. In Search of the Engram

IV. Nucleoproteins Increased with Brain Activity

V. RNA as the Memory Molecule

VI. Short-Term and Long-Term Memory: Proteins for Coding?

VII. Interanimal Transfer of Acquired Information

VIII. Scotophobin: First Deciphered Word of a New Biological Code?

IX. A Theory for the Mode of Action of Memory Peptides

X. Conclusion

References

Protein Kinases

I. Introduction

II. General Aspects

III. Protein Kinases and the Regulation of Glycogen Metabolism

IV. Cyclic AMP-Dependent Protein Kinases

V. Protein Kinases and the Regulation of Lipid Metabolism

VI. Protein Kinases and the Regulation of Nuclear Activity

VII. The Regulation of Adrenal Steroid Production

VIII. Protein Kinases and the Regulation of Pyruvic Dehydrogenase

IX. Protein Kinases and the Regulation of Other Systems

References

Glutamine Phosphoribosylpyrophosphate Amidotransferase

I. Introduction

II. Kinetics and Mechanism of Action

III. Structure

IV. Regulation of Activity

V. Enzyme Induction, Derepression, and Repression

VI. Summary

References

The Regulatory Influence of Allosteric Effectors on Deoxycytidylate Deaminases

I. Introduction

II. Feedback Regulation of Deoxycytidylate Deaminase

III. Allosteric Transitions Effected by the Regulatory Ligands

IV. Active and Inactive States Associated with Deoxycytidylate Deaminase

V. Use of Inhibitors to Define the Physiological Significance of Deoxycytidylate Deaminase

VI. Distribution and Role Deoxycytidylate Deaminase in Bacterial Systems

VII. Regulatory Responses of the Bacteriophage-Induced Deoxycytidylate Deaminases to Its Metabolic End Products

VIII. Physical and Chemical Properties of the T2r* Bacteriophage-Induced Deoxycytidylate Deaminase

IX. The Effect of pH on the Allosteric Response of Deoxycytidylate Deaminase

X. Studies on the in Vitro Synthesis of Bacteriophage-Induced Deoxycytidylate Deaminase

IX . Conclusion

References

The Citrate Enzymes: Their Structures. Mechanisms. and Biological Functions

I. Introduction

II. Citrate Lyase (Citritase)

III. Citrate Synthase

IV. ATP Citrate Lyase (Citrate Cleavage Enzyme)

V. Overview

References

Regulation of Histidine Biosynthesis in Salmonella typhimurium

I. Introduction

II. The Enzymes of Histidine Biosynthesis

III. The Operon

IV. Feedback Inhibition

V. Repression

VI. Other Possible Mechanisms of Regulation

References

Author Index

Subject Index