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Current Topics in Cellular Regulation
1st Edition, Volume 2 - December 28, 1970
Editors: Bernard L. Horecker, Earl R. Stadtman
Language: English
eBook ISBN:9781483217017
9 7 8 - 1 - 4 8 3 2 - 1 7 0 1 - 7
Current Topics in Cellular Regulation, Volume 2 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation,…Read more
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Current Topics in Cellular Regulation, Volume 2 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into eight chapters, this volume begins with an overview of the occurrence of the enzyme in plants and microorganisms. This text then examines the biosynthesis of aromatic amino acids and vitamins, which is proving an interesting model system for the study of regulation. Other chapters consider the control of cholesterol biosynthesis in normal tissues, with emphasis on the pathologic implications of derangements of cholesterol feedback control. This book discusses as well the aspects of the biogenesis of yeast mitochondria. The final chapter deals with regulation in the pyrimidine biosynthetic pathway at the level of enzyme activity. This book is a valuable resource for biochemists, biologists, and research workers.
List of Contributors
Preface
Contents of Volume 1
DPN-Linked Isocitrate Dehydrogenase of Animal Tissues
I. Introduction
II. Properties
III. Effect of Nucleotides
IV. Other Activators, Stabilizers, and Inhibitors
V. Control of Mitochondrial Isocitrate Oxidation
References
The Regulation of Biosynthesis of Aromatic Amino Acids and Vitamins
I. Introduction
II. Regulation of the Common Pathway
III. Regulation of the Tryptophan Pathway
IV. Regulation of Phenylalanine and Tyrosine Biosynthesis
V. Regulation of Vitamin Biosynthesis
VI. Conclusion
References
Regulation of Cholesterol Biosynthesis in Normal and Malignant Tissues
I. Introduction
II. Feedback Control of Cholesterol Synthesis
III. Feedback Inhibition of Cholesterol Synthesis in the Intestine
IV. The Effect of Fasting upon Cholesterol Synthesis
V. Other Factors Affecting Cholesterol Synthesis
VI. Cancer and the Control of Cholesterol Synthesis
VII. Summary
References
The Biogenesis of Yeast Mitochondria
I. General Physiology and Biochemistry of Saccharomyces cerevisiae
II. Genetic Systems
III. Mitochondrial DNA
IV. Protein Synthesis
References
Note Added in Proof
Fructose 1,6-Diphosphatase from Rabbit Liver
I. Introduction
II. Properties of Purified Liver FDPase
III. Desensitization against Inhibition by AMP
IV. Subunit Structure
V. Number of Binding Sites for Substrate, AMP, and Divalent Cation
VI. Modification of Catalytic Activity at Neutral pH
VII. Discussion
References
The Role of Phosphoribosyltransferases in Purine Metabolism
I. Introduction
II. Properties of Phosphoribosyltransferases
III. Role of Phosphoribosyltransferases in Purine Metabolism
IV. Conclusions
References
Concentrations of Metabolites and Binding Sites. Implications in Metabolic Regulation
I. Introduction
II. Some Metabolic Consequences of Cellular, Subcellular, and Intercellular Compartmentation
III. Metabolites and Binding Sites
IV. Other Factors That Can Affect the Active Concentration of Metabolites
V. Kinetic Problems When [Enzyme] > [Substrate]
VI. Particular Problems When the Substrate Is about as Large or Much Larger than the Enzyme
VII. Final Remarks
References
A Discussion of the Regulatory Properties of Asportate Transcarbamylase from Escherichia coli
I. Introduction
II. Properties of the Catalytic Subunit
III. Properties of the Regulatory Subunit
IV. Arrangement and Interaction of Polypeptide Chains in ATCase
References
Author Index
Subject Index
No. of pages: 364
Language: English
Edition: 1
Volume: 2
Published: December 28, 1970
Imprint: Academic Press
eBook ISBN: 9781483217017
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