Current State of Alzheimer's Disease Research and Therapeutics - 1st Edition - ISBN: 9780123948168, 9780123948458

Current State of Alzheimer's Disease Research and Therapeutics, Volume 64

1st Edition

Serial Volume Editors: Mary Lou Michaelis Elias K. Michaelis
Hardcover ISBN: 9780123948168
eBook ISBN: 9780123948458
Imprint: Academic Press
Published Date: 2nd August 2012
Page Count: 400
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Table of Contents


Hsp90 Modulation for the Treatment of Alzheimer’s Disease

I Introduction

II Hsp90 Complexes in Alzheimer’s Disease

III Potential Therapeutic Effects of Hsp90 Inhibitors in Alzheimer’s Disease

IV Conclusion

Using Pittsburgh Compound B for In Vivo PET Imaging of Fibrillar Amyloid-Beta

I Introduction

II Rationale for Studying Amyloid Deposition

III General Properties of the Aβ Imaging Tracer, PiB

IV Early Human PiB Studies

V Amyloid Imaging and Apolipoprotein-E Genotype

VI Amyloid Imaging in Normal Controls

VII Amyloid Imaging in MCI

VIII Amyloid Deposition in Early-Onset, Autosomal Dominant, Familial AD

IX Frontotemporal Dementia

X Dementia with Lewy Bodies and Parkinson’s Disease

XI Cerebral Amyloid Angiopathy (CAA)

XII Atypical Presentations of AD

XIII Postmortem Validation of PiB-PET Imaging

XIV Amyloid Imaging Compared to Other Biomarkers

XV Amyloid Imaging in AD Drug Development

XVI F-18 Compounds

XVII Detection of the Earliest Signs of Amyloid Deposition

XVIII Limitations, Validity, and Unresolved Questions

XIX Conclusion

List of Abbreviations

Mitochondrial Abnormalities in Alzheimer’s Disease

I Introduction

II Mitochondrial Function in AD

III Mitochondria as a Therapeutic Target in AD

IV Conclusion


γ-Secretase as a Target for Alzheimer’s Disease

I Introduction

II γ-Secretase in Alzheimer’s Disease

III γ-Secretase in Biology

IV Biochemistry of the γ-Secretase Complex

V Inhibitors

VI Modulators

VII Conclusion


Altering Mitochondrial Dysfunction as an Approach to Treating Alzheimer’s Disease

I Introduction

II Theories of Pathogenesis and the Natural History of Alzheimer’s Disease

III Other Pathologies Can Affect Mitochondrial Function

IV Mitochondrial Function Can Exacerbate Other Pathology

V Therapeutic Approaches Being Taken and Opportunities Suggested

VI Conclusion


scyllo-Inositol, Preclinical, and Clinical Data for Alzheimer’s Disease

I Introduction

II Preclinical Development of scyllo-Inositol

III Sources of scyllo-Inositol

IV Bioavailability and Metabolism

V Human Clinical Trials of scyllo-Inositol as an AD Therapeutic

VI Structure–Function Analysis of scyllo-Inositol

VII Inositol for the Treatment of Other Disorders

VIII Conclusion


Beyond Amyloid

I Introduction

II Current Therapeutic Targets

III Conclusion


Activation of Protein Kinase C Isozymes for the Treatment of Dementias

I Introduction

II PKC Signaling System

III Memory and Alzheimer’s Dementia

IV Ischemic Dementia

V Conclusion


Striatal-Enriched Protein Tyrosine Phosphatase in Alzheimer’s Disease

I Introduction

II Striatal-Enriched Protein Tyrosine Phosphatase (STEP)

III STEP Inhibitors

IV Conclusion


Estrogen Regulation of Mitochondrial Bioenergetics

I Introduction: Alzheimer’s Disease—Unlimited Cost/Limited Windows of Therapeutic Opportunity

II Role of Mitochondrial Bioenergetics in Alzheimer’s Pathogenesis

III Estrogen Action in the Brain-Convergence upon Mitochondrial Bioenergetics and Brain Metabolism

IV Healthy Cell Bias of Estrogen Action: Consolidation of Clinical Observations and Basic Mechanistic Discoveries

V Clinical Implications for Biomarker Identification and Therapeutic Development for Alzheimer’s Disease

VI Conclusion



Recent Volumes in the Serial


This new volume of Advances in Pharmacology explores the Current State of Alzheimer's Disease Research and Therapeutics. Chapters cover such topics as the The role heat shock proteins play in the Alzheimer's Theater, Gamma-Secretase as a Target for Alzheimer's Disease, and Identification of protein kinase C for the treatment of dementias. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Key Features

  • Explores the current state of Alzheimer's disease research and therapeutics
  • Chapters cover a variety of topics such as the role heat shock proteins play in the Alzheimer's theater, gamma-secretase as a target for Alzheimer's disease, and identification of protein kinase C for the treatment of dementias
  • With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike


Pharmacologists, immunologists, and biochemists


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© Academic Press 2012
Academic Press
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About the Serial Volume Editors

Mary Lou Michaelis Serial Volume Editor

Elias K. Michaelis Serial Volume Editor