Description

This new volume of Advances in Pharmacology explores the Current State of Alzheimer's Disease Research and Therapeutics. Chapters cover such topics as the The role heat shock proteins play in the Alzheimer's Theater, Gamma-Secretase as a Target for Alzheimer's Disease, and Identification of protein kinase C for the treatment of dementias. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Key Features

  • Explores the current state of Alzheimer's disease research and therapeutics
  • Chapters cover a variety of topics such as the role heat shock proteins play in the Alzheimer's theater, gamma-secretase as a target for Alzheimer's disease, and identification of protein kinase C for the treatment of dementias
  • With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

Readership

Pharmacologists, immunologists, and biochemists

Table of Contents

Contributors

Hsp90 Modulation for the Treatment of Alzheimer’s Disease

I Introduction

II Hsp90 Complexes in Alzheimer’s Disease

III Potential Therapeutic Effects of Hsp90 Inhibitors in Alzheimer’s Disease

IV Conclusion

Using Pittsburgh Compound B for In Vivo PET Imaging of Fibrillar Amyloid-Beta

I Introduction

II Rationale for Studying Amyloid Deposition

III General Properties of the Aβ Imaging Tracer, PiB

IV Early Human PiB Studies

V Amyloid Imaging and Apolipoprotein-E Genotype

VI Amyloid Imaging in Normal Controls

VII Amyloid Imaging in MCI

VIII Amyloid Deposition in Early-Onset, Autosomal Dominant, Familial AD

IX Frontotemporal Dementia

X Dementia with Lewy Bodies and Parkinson’s Disease

XI Cerebral Amyloid Angiopathy (CAA)

XII Atypical Presentations of AD

XIII Postmortem Validation of PiB-PET Imaging

XIV Amyloid Imaging Compared to Other Biomarkers

XV Amyloid Imaging in AD Drug Development

XVI F-18 Compounds

XVII Detection of the Earliest Signs of Amyloid Deposition

XVIII Limitations, Validity, and Unresolved Questions

XIX Conclusion

List of Abbreviations

Mitochondrial Abnormalities in Alzheimer’s Disease

I Introduction

II Mitochondrial Function in AD

III Mitochondria as a Therapeutic Target in AD

IV Conclusion

Abbreviations

γ-Secretase as a Target for Alzheimer’s Disease

I Introduction

II γ-Secretase in Alzheimer’s Disease

III γ-Secretase in Biology

IV Biochemistry of the γ-Secretase Complex

V Inhibitors

VI Modulators

VII Conclusion

Abbreviations

Altering Mitochondrial Dysfunction as an Approach to Treating Alzheimer’s Disease

I Introduction

II Theories of Pathogenesis and the Natural History of Alzheimer’s Dise

Details

No. of pages:
400
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
Print ISBN:
9780123948168
Electronic ISBN:
9780123948458