COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Current Developments in Biotechnology and Bioengineering - 1st Edition - ISBN: 9780444640857, 9780444640864

Current Developments in Biotechnology and Bioengineering

1st Edition

Synthetic Biology, Cell Engineering and Bioprocessing Technologies

Editors: Sudhir Singh Ashok Pandey Guocheng Du Sudesh Kumar
Paperback ISBN: 9780444640857
eBook ISBN: 9780444640864
Imprint: Elsevier
Published Date: 20th November 2018
Page Count: 442
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Current Developments in Biotechnology and Bioengineering: Synthetic Biology, Cell Engineering and Bioprocessing Technologies covers the current perspectives and outlook of synthetic biology in the agriculture, food and health sectors. This book begins with the basics about synthetic biology and cell engineering, and then explores this in more detail, focusing on topics like applications of synthetic biology, industrial bioprocesses, and future perspectives. Information on cell engineering is also presented, and manipulation in endogenous metabolic network is studied alongside advanced topics such as fine tuning of metabolic pathways, de novo biosynthetic pathway design, enzyme engineering targeted to improved kinetics and stability, and potential applications of the novel biological systems in bioprocess technology to achieve the production of value-added compounds with specific biological activities.

Key Features

  • Assists in developing a conceptual understanding of synthetic biology and cellular and metabolic engineering.
  • Includes comprehensive information on new developments and advancements.
  • Lists applications of synthetic biology in agriculture, food, and health


Graduate and post-graduate students, doctoral fellows, researchers, mentors, teachers, and specific trainees in the area of biochemical engineering /biotechnology

Table of Contents

Section 1: Synthetic biological systems; Concepts and molecular toolkits
1. Basics and roots of synthetic biology
2. Advances in cell-free biosynthetic technology
3. Genome engineering tools in plant synthetic biology

Section 2: Genome engineering and biosynthetic repertoires
4. Constructing synthetic pathways in plants: Strategies and tools
5. Synthetic regulatory tools to engineer microbial cell factories for chemical production
6. A CRISPR technology and biomolecule production by synthetic biology approach

Section 3: Biocatalyst engineering and industrial bioprocesses
7. Enzyme engineering and industrial bioprocess
8. Synthetic biology for production of commercially important natural product small molecules
9. Biosynthetic technology and bioprocess engineering

Section 4: Applications of Synthetic Biology
10. Regulated gene expression by synthetic modulation of the promoter architecture in plants
11. Biosynthesis of high-value amino acids by synthetic biology
12. Synthetic biology approaches for the production of 2-butanol
13. Synthetic biology approaches for the production of isoprenoids in Escherichia coli
14. System metabolic engineering applications in Corynebacterium crenatum for L-Arginine production

Section 5: Future perspectives of synthetic metabolism
15. Synthetic metabolism and its significance in agriculture
16. Applications and future perspectives of synthetic biological systems


No. of pages:
© Elsevier 2018
20th November 2018
Paperback ISBN:
eBook ISBN:

About the Editors

Sudhir Singh

Dr. Sudhir P. Singh obtained his Ph.D. in the year 2011 from University of Lucknow, India. Subsequently, he worked as research associate and then as Project Scientist at National Agri-Food Biotechnology Institute, Mohali, India. He joined Center of Innovative and Applied Bioprocessing, Mohali, India in 2015, as Scientist-C. He has been working in the area of molecular biology, and synthetic biology. In the area of plant molecular biology his some of the significant contribution are: development stringently regulated expression systems for inducing male sterility and male sterility-fertility restoration system in plants, investigation of tissue and cell-type specific distribution pattern of mineral nutrients in wheat grains and its possible impacts on bioavailability, the first transcriptome analysis and molecular insights into seed development biology in the fruit crops, Custard apple and Litchi, and secondary metabolite pathways in Rose-scented geranium, development of approaches based on Rootstock-scion or modified viral genome based long distance signalling as possible strategies for inducing trait modification such as seedlessness. His current research focus is towards development of synthetic biocatalysts for biotransformation of agro-industrial by-products and residues into value added biomolecules. In the area of biosynthetic technology his some of the significant contribution are: development of novel approaches for transformation of agro-industrial residues and bioresources into functional and prebiotic biomolecules, development of a novel strategy for the improvement of operational stability of D-psiose 3-epimerase enzyme. He has been interested in employing the basic knowledge for translational research. He has published 33 research papers in peer reviewed journals, 4 review articles/book chapters, and 4 patents to his credit.

Affiliations and Expertise

Center of Innovative and Applied Bioprocessing, Mohali, India

Ashok Pandey

Ashok Pandey

Professor Ashok Pandey is currently Distinguished Scientist at the Centre for Innovation and Translational Research, CSIR-Indian Institute of Toxicology Research, Lucknow, India and Executive Director (Honorary) at the Centre for Energy and Environmental Sustainability – India. Formerly, he was Eminent Scientist at the Center of Innovative and Applied Bioprocessing, Mohali and Chief Scientist & Head of Biotechnology Division and Centre for Biofuels at CSIR’s National Institute for Interdisciplinary Science and Technology, Trivandrum. His major research and technological development interests are industrial & environmental biotechnology and energy biosciences, focusing on biomass to biofuels & chemicals, waste to wealth & energy, industrial enzymes, etc. Professor Pandey is Adjunct/Visiting Professor/Scientist in universities in France, Brazil, Canada, China, Korea, South Africa, and Switzerland and also in several universities several in India. He has ~1425 publications/communications, which include 16 patents, 90 books, >700 papers and book chapters, etc with h index of 105 and ~48,800 citations (Goggle scholar). He has transferred several technologies to industries and has done industrial consultancy for about a dozen projects for Indian/international industries. Professor Pandey is the recipient of many national and international awards and honours, which include Highest Cited Researcher (Top 1% in the world), Clarivate Analytics, Web of Science (2020, 2019 & 2018); Top scientist in Biotechnology (#1 in India and #8 in the world), Stanford University world ranking (2020); Fellow, World Society of Sustainable Energy Technologies (2020); Fellow, Indian Chemical Society (2020); Distinguished Scientist, VDGOOD Professional Association, India (2020); Distinguished Professor of Eminence with global impact in the area of Biotechnology, Precious Cornerstone University, Nigeria (2020); IconSWM Life-time Achievement Award 2019, International Society for Solid Waste Management, KIIT, Bhubaneshwar, India (2019); Yonsei Outstanding Scholar, Yonsei University, Seoul, Korea (2019); Life-Time Achievement Award from the Biotech Research Society, India (2018); Life-Time Achievement Award from Venus International Research Awards (2018), Most Outstanding Researcher Award from Career360 (2018), Life-Time Achievement Award from the International Society for Energy, Environment and Sustainability (2017); Fellow, Royal Society of Biology, UK (2016); Felow, International Society for Energy, Environment and Sustainability (2016); Academician of European Academy of Sciences and Arts, Austria (2015); Fellow, National Academy of Sciences, India (2012); Fellow, Association of Microbiologists of India (2008); Honorary Doctorate degree from Univesite Blaise Pascal, France (2007); Fellow, International Organization of Biotechnology and Bioengineering (2007); Thomson Scientific India Citation Laureate Award, USA (2006); Fellow, the Biotech Research Society, India (2005); UNESCO Professor (2000); Raman Research Fellowship Award, CSIR (1995); GBF, Germany and CNRS, France Fellowships (1992) and Young Scientist Award (1989), etc. Professor Pandey is Founder President of the Biotech Research Society, India (; Founder & International Coordinator of International Forum on Industrial Bioprocesses, France (, Chairman of the International Society for Energy, Environment & Sustainability (, Editor-in-chief of Bioresource Technology (, Honorary Executive Advisor of Journal of Energy and Environmental Sustainability (, Journal of Systems Microbiology and Biomanufacturing (, Journal of Environmental Sciences and Engineering (, Subject Editor, Proceedings of National Academy of Sciences, India ( and Associate Editor, Biologia – Section Cellular and Molecular Biology ( and editorial board member of several international and Indian journals.

Affiliations and Expertise

Distinguished Scientist, Centre for Innovation and Translational Research, CSIR-Indian Institute of Toxicology Research, Lucknow, India

Guocheng Du

Professor Guocheng Du is the Dean of School of Biotechnology, Jiangnan University, China. He is the distinguished professor of Changjiang Scholars, Ministry of Education, China. His current main research focus is on bioprocess engineering and metabolic engineering. He has about 200 publications/communications, which include 52 patents, 8 books, 160 original and review papers, etc. He won two Second Prizes of State Science and Technology Award in 2006 and 2012, respectively. He has been conferred Honorary Doctorate degree from Jiangnan University, China. Professor Guocheng Du is deputy director in the committee of biochemical engineering modelling and control, Chinese Society for Microbiology, and deputy director of Beer Branch, China Alcoholic Drinks Industry Association. He is the associate editor of Journal of the Science of Food and Agriculture and the editorial board member of Bioresource Technology.

Affiliations and Expertise

Dean of the School of Biotechnology, Jiangnan University, China

Sudesh Kumar

Dr Sudesh Kumar obtained his PhD in 2002 from the Department of Biochemistry, CCS Haryana Agricultural University, Hisar. Subsequently, he worked as post-doctoral fellow at ICGEB, New Delhi (2002-2004). He joined CSIR-Institute of Himalayan Bioresource Technology, Palampur in 2004 as Scientist. In April, 2016, he joined as Scientist-F at Center of Innovative and Applied Bioprocessing (CIAB). He has been working in the area of plant metabolic engineering and nanobiology and current research focus is towards improving the efficacy of hydrolytic enzymes through synthetic biology and nanobiology approaches for developing the efficient transformation process for biomass into value added products. Dr Kumar has published 110 research articles in peer reviewed journals, one book and 12 book chapters. His work has been cited 5000 times and has an h-index of 35. For his outstanding research contributions in the area of plant sciences, he has been honoured with many prestigious awards such as Indian National Science Academy (INSA)-Young Scientist Award- 2008, The National Academy of Science, India (NASI)-Platinum Jubilee Young Scientist Award-2009, Council of Scientific and Industrial Research (CSIR)-Young Scientist Award-2010. He has been awarded BOYSCAST Fellowship during 2008 by DST, GOI for conducting advanced research at UCR, Riverside, USA for one year. He has been also selected “NAAS-Associate” by the National Academy of Agricultural Sciences from 2013 and conferred “Prof. Hira Lal Chakravarty Memorial Award” of Indian Science Congress Association (ISCA) for the year 2012-2013. He has been honoured with “Haryana Yuva Vigyan Ratna Award” 2011-12 for his excellent research contributions.

Affiliations and Expertise

Center of Innovative and Applied Bioprocessing, Knowledge City, Mohali, Punjab, India

Ratings and Reviews