Current Developments in Biotechnology and Bioengineering

Current Developments in Biotechnology and Bioengineering

Bioprocesses, Bioreactors and Controls

1st Edition - September 15, 2016

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  • Editors: Christian Larroche, M. Sanroman, Guocheng Du, Ashok Pandey
  • Hardcover ISBN: 9780444636638
  • eBook ISBN: 9780444636744

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Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, reviewing industrial biotechnology and bioengineering practices that facilitate and enhance the transition of processes from lab to plant scale, which is becoming increasingly important as such transitions continue to grow in frequency. Focusing on industrial bioprocesses, bioreactors for bioprocesses, and controls for bioprocesses, this title reviews industrial practice to identify bottlenecks and propose solutions, highlighting that the optimal control of a bioprocess involves not only maximization of product yield, but also taking into account parameters such as quality assurance and environmental aspects.

Key Features

  • Describes industrial bioprocesses based on the reaction media
  • Lists the type of bioreactors used for a specific bioprocess/application
  • Outlines the principles of control systems in various bioprocesses


Postgraduate and PhD students and researchers in academia, government and corporate research in the area of bioengineering/biochemical engineering, biomedical/biological engineering and industrial biotechnology

Table of Contents

  • Industrial Bioprocesses

    1. Industrial bioprocesses and the biorefinery concept

    2. Omics tools for bioprocess development

    3. Cell factories for industrial bioprocesses

    4. Enzyme systems for industrial bioprocesses

    5. Design and types of bioprocesses

    6. Bioprocess engineering and process optimization

    7. Microbial bioprocesses

    8. Plant cell bioprocesses

    9. Animal cell bioprocesses

    10. Biofilm bioprocesses

    Bioreactors for Industrial Bioprocesses

    11. Basics of Bioreactor Design

    12. Stirred-Tank Bioreactors

    13. Nonmechanically Agitated Bioreactors

    14. Packed-bed Bioreactors

    15. Membrane Bioreactors

    16. Photobioreactors

    17. Solid-State Fermentation Bioreactor Fundamentals

    18. Bioreactor Development for the Cultivation of Extremophilic Microorganisms

    19. Application of Microbioreactors for Bioprocesses

    20. Modeling and Control of Bioreactors

    21. Scale-up strategies of Bioreactors

    Controls of Industrial Bioprocesses

    22. Principles of bioprocess control

    23. Characterization of industrial bioreactors (mixing, mass and heat transfer)

    24. Present status of standard instruments for bioprocess analysis and control

    25. Biosensors

    26. Real-time Knowledge-Based Systems

Product details

  • No. of pages: 850
  • Language: English
  • Copyright: © Elsevier 2016
  • Published: September 15, 2016
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444636638
  • eBook ISBN: 9780444636744

About the Editors

Christian Larroche

Professor Christian Larroche is a graduate in Biochemical Engineering from the INSA, Toulouse, (1979), Docteur-Ingénieur in Organic Chemistry from Paul Sabatier Toulouse 3 University (1982), and Docteur ès Sciences (Ph D) in Biochemical Engineering from Blaise Pascal University (1990). He has strong research interest in the area of applied microbiology and biochemical engineering. His skills are related to biochemical engineering, especially the study and development of special processes for the use of microorganisms. This includes fungal spores production by solid state cultivation and their use as protein (enzyme) reservoir in biotransformations. A special interest in phase transfer phenomena coupled to metabolic engineering has to be noticed. It is applied to the design and optimisation of biotransformations involving hydrophobic compounds and carried out in biphasic liquid-liquid media. These processes are related both to the food and environment (bioremediation) areas. His interests have recently be extended to bioenergy, and he is presently co-ordinator of two French research programs on biohydrogen production by non photosynthetic anaerobic microorganisms grown on complex media.

He is author of about 170 documents, including 75 articles, two patents, 12 book chapters and 18 co-edition of books or journal special issues. He has supervised 10 PhD students and 20 MSc lab works. He is member of SFGP (French Society for Process Engineering) and vice chairman & administrator of IFIBiop, an international network entitled "International Forum on Industrial Bioprocesses". He is head of the department of "Study and Development of Processes involving Microorganisms" of the platform for technological development Biotechnology – Material Engineering of Blaise Pascal University and belongs to the team GePEB (Process engineering, Energetics and Biosystems) of the Institut Pascal in the same university. He has been vice-president of the university in charge of research valorization and technology transfer (2008-2012) and is currently director of Polytech Clermont-Ferrand, a graduate school of engineering of Blaise Pascal University.

Affiliations and Expertise

Head of the department for the Study and Development of Processes involving Microorganisms, School of Material Engineering, Blaise Pascal University, France

M. Sanroman

Professor M. Angeles Sanroman is a graduate in Chemical Engineering from the University of Santiago de Compostela, Spain (1987). She did her PhD degree in Biotechnology (1991), focusing on development of bioreactor and cell immobilization techniques. She joined the staff at University of Vigo in the Department of Chemical Engineering. She is the Head of the Bioengineering & Sustainable Processes Group at University of Vigo. This is a multidisciplinary research group that joins knowledge and efforts in the development of technologies to be applied in several industrial sectors. Nowadays, the main research lines carried out are Biodegradation of recalcitrant organic compounds, Solid state fermentation, Enzymatic technology, Bioreactors design and Advanced Oxidation Technologies. The results of these research works have been published in more than 220 papers, 5 patents, 18 chapters of books and more than 350 research communications. She has collaborated in more than 50 research and innovation projects at national and international calls and various contracts and actions in relation to the transference of technology to business administration and companies. In this context, her activity as a researcher is remarkable, being director of the Research Results Transfer Office of the University of Vigo, member of ANEP - Spanish Ministry of Economy and Competitiveness in the Chemical Technology Area (2007- 2011) and Technology Transfer Area (2015-now), regular evaluator of research projects in competitive calls for various national and international programs and member of the editorial board of several journals, including Bioresource Technology as Associate Editor.

Affiliations and Expertise

Head of the Bioengineering and Sustainable Processes Group, University of Vigo, Spain

Guocheng Du

Professor Guocheng Du works in School of Biotechnology, Jiangnan University, China. He is the distinguished professor of Changjiang Scholars, Ministry of Education, China. His current main research focus is on bioprocess engineering and metabolic engineering. He has about 230 publications/communications, which include 60 patents, 8 books, 210 original and review papers, etc. He won two Second Prizes of State Science and Technology Award in 2006 and 2012, respectively. He has been conferred Honorary Doctorate degree from Jiangnan University, China. Professor Guocheng Du is deputy director in the committee of biochemical engineering modelling and control, Chinese Society for Microbiology, and deputy director of Beer Branch, China Alcoholic Drinks Industry Association. He is the associate editors of Journal of the Science of Food and Agriculture and Microbial cell Factories, and the editorial board member of Bioresource Technology.

Affiliations and Expertise

Professor, School of Biotechnology, Jiangnan University, China

Ashok Pandey

Ashok Pandey
Professor Ashok Pandey is currently Distinguished Scientist at the Centre for Innovation and Translational Research, CSIR-Indian Institute of Toxicology Research, Lucknow, India and Executive Director (Honorary) at the Centre for Energy and Environmental Sustainability – India. Formerly, he was Eminent Scientist at the Center of Innovative and Applied Bioprocessing, Mohali and Chief Scientist & Head of Biotechnology Division and Centre for Biofuels at CSIR’s National Institute for Interdisciplinary Science and Technology, Trivandrum. His major research and technological development interests are industrial & environmental biotechnology and energy biosciences, focusing on biomass to biofuels & chemicals, waste to wealth & energy, industrial enzymes, etc. Professor Pandey is Adjunct/Visiting Professor/Scientist in universities in France, Brazil, Canada, China, Korea, South Africa, and Switzerland and also in several universities several in India. He has ~1425 publications/communications, which include 16 patents, 90 books, >700 papers and book chapters, etc with h index of 105 and ~48,800 citations (Goggle scholar). He has transferred several technologies to industries and has done industrial consultancy for about a dozen projects for Indian/international industries. Professor Pandey is the recipient of many national and international awards and honours, which include Highest Cited Researcher (Top 1% in the world), Clarivate Analytics, Web of Science (2020, 2019 & 2018); Top scientist in Biotechnology (#1 in India and #8 in the world), Stanford University world ranking (2020); Fellow, World Society of Sustainable Energy Technologies (2020); Fellow, Indian Chemical Society (2020); Distinguished Scientist, VDGOOD Professional Association, India (2020); Distinguished Professor of Eminence with global impact in the area of Biotechnology, Precious Cornerstone University, Nigeria (2020); IconSWM Life-time Achievement Award 2019, International Society for Solid Waste Management, KIIT, Bhubaneshwar, India (2019); Yonsei Outstanding Scholar, Yonsei University, Seoul, Korea (2019); Life-Time Achievement Award from the Biotech Research Society, India (2018); Life-Time Achievement Award from Venus International Research Awards (2018), Most Outstanding Researcher Award from Career360 (2018), Life-Time Achievement Award from the International Society for Energy, Environment and Sustainability (2017); Fellow, Royal Society of Biology, UK (2016); Felow, International Society for Energy, Environment and Sustainability (2016); Academician of European Academy of Sciences and Arts, Austria (2015); Fellow, National Academy of Sciences, India (2012); Fellow, Association of Microbiologists of India (2008); Honorary Doctorate degree from Univesite Blaise Pascal, France (2007); Fellow, International Organization of Biotechnology and Bioengineering (2007); Thomson Scientific India Citation Laureate Award, USA (2006); Fellow, the Biotech Research Society, India (2005); UNESCO Professor (2000); Raman Research Fellowship Award, CSIR (1995); GBF, Germany and CNRS, France Fellowships (1992) and Young Scientist Award (1989), etc. Professor Pandey is Founder President of the Biotech Research Society, India (; Founder & International Coordinator of International Forum on Industrial Bioprocesses, France (, Chairman of the International Society for Energy, Environment & Sustainability (, Editor-in-chief of Bioresource Technology (, Honorary Executive Advisor of Journal of Energy and Environmental Sustainability (, Journal of Systems Microbiology and Biomanufacturing (, Journal of Environmental Sciences and Engineering (, Subject Editor, Proceedings of National Academy of Sciences, India ( and Associate Editor, Biologia – Section Cellular and Molecular Biology ( and editorial board member of several international and Indian journals.

Affiliations and Expertise

Distinguished Scientist, Centre for Innovation and Translational Research, CSIR-Indian Institute of Toxicology Research, Lucknow, India

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