Description

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Key Features

  • Explores the current concepts in drug metabolism and toxicology
  • Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity
  • An essential resource for pharmacologists, immunologists and biochemists alike
  • Readership

    Pharmacologists, immunologists, and biochemists

    Table of Contents

    1. Membrane Transporters in Drug Development
    2. J.P.  Keogh

    3. The Keap1-Nrf2 Cell Defence Pathway - A Promising Therapeutic Target?
    4. Ian M. Copple

    5. Animal Models of Idiosyncratic Drug Reactions
    6. Winnie Ng, Alexandra R.M. Lobach, Xu Zhu, Xin Chen, Feng Liu, Imir G. Metushi, Amy Sharma, Jinze Li, Ping Cai, Julia Ip, Maria Novalen, Marija Popovic, Xiaochu Zhang, Tadatoshi Tanino, Tetsuya Nakagawa and Jack Uetrecht.

    7. Genetic Polymorphisms Affecting Drug Metabolism: Recent Advances and Clinical Aspects
    8. Ann K. Daly

    9. Arylamine N-Acetyltransferases - from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention
    10. Oliver J. Rando

    11. Human Pluripotent Stem Cells for Modelling Toxicity
    12. R.L.C. Sison , R. Kia, J. Heslop, L. Kelly, C. Rowe, M. J. Cross, N. R. Kitteringham, N. Hanley, B. K.Park and C.E.P. Goldring

    13. Disposition of Biologics

    Kevin Brady and Rob Webster

    Details

    No. of pages:
    304
    Language:
    English
    Copyright:
    © 2012
    Published:
    Imprint:
    Academic Press
    Print ISBN:
    9780123983398
    Electronic ISBN:
    9780123983596