Current Concepts in Cardiovascular Physiology

Current Concepts in Cardiovascular Physiology

1st Edition - June 28, 1990

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  • Editor: Oscar Garfein
  • eBook ISBN: 9780323145961

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Current Concepts in Cardiovascular Physiology examines seven different areas related to the field of cardiac physiology. In addition to the biochemistry and receptor pharmacology of the heart, this book explores coronary physiology, cardiovascular function, and neural and reflex control of the circulation. The electrophysiology and biophysics of cardiac excitation are also considered, along with humoral control of the circulation. This monograph consists of seven chapters and opens with an overview of the biochemistry of the heart, with emphasis on cardiac energy metabolism and the ways in which metabolism and the biochemical pathways are controlled. The mechanisms whereby physiological events influence biochemical activities and vice versa are also discussed. The following chapters look at the chemistry and physiology of myocardial receptors; the complex interplay between the nervous and cardiovascular systems; and the chemical and hormonal factors that regulate, modify, and modulate the cardiovascular system. The influence of humoral, neural, intrinsic, vascular, and myocardial factors on coronary blood flow is also examined, along with muscle mechanics; the biochemical basis of contraction; cardiac function; and the factors determining the heart's electrophysiologic behavior. This text is directed primarily at clinical cardiologists, cardiovascular surgeons, and trainees in their disciplines, as well as internists, medical students, and house officers.

Table of Contents

  • Preface

    1. Biochemistry of the Heart

    I. Cardiac Metabolism

    II. Concepts of Metabolic Regulation

    III. Metabolism of Energy-Providing Substrates

    IV. Fatty Acids

    V. Ketone Bodies

    VI. Amino Acids

    VII. Competition of Substrates for the Supply of Acetyl-CoA

    VIII. Control of the Tricarboxylic Acid Cycle

    IX. Physiological Implications

    X. Pathophysiological Implications: Metabolic Alterations in Myocardial Ischemia

    XI. Energy Metabolism in Cardiac Hypertrophy

    XII. Concluding Remarks


    2. Receptor Pharmacology of the Human Heart

    I. What is a Receptor

    II. Receptor Identification

    III. Receptor Mechanisms in Cardiac Tissue

    IV. Summary

    V. Appendix


    3. Neural and Reflex Control of the Circulation

    I. Introduction

    II. Central Nervous System

    III. Neural Control of the Blood Vessels

    IV. Neural Control of the Heart

    V. Reflex Control of the Circulation


    4. Humoral Control of the Circulation

    I. Historical Introduction

    II. Pressor Systems

    III. Depressor Systems


    5. Coronary Physiology

    I. Basic Anatomy

    II. Myocardial Oxygen Demand

    III. Myocardial Oxygen Supply

    IV. Transmural Flow

    V. Neurohumoral Control of Coronary Blood Flow

    VI. Ventricular Hypertrophy

    VII. Right Ventricular Coronary Flow

    VIII. Pathophysiology of Coronary Artery Disease

    References 334

    6. Cardiovascular Function

    I. Introduction

    II. Cardiac Muscle and Cell Properties

    III. Global Ventricular Function


    7. A Matrical Approach to the Electrophysiology and Biophysics of Cardiac Excitation

    I. Introduction

    II. Structure and Bioelectricity

    III. Ionic Concentrations, Activities, and Pumps

    IV. Passive Cellular and Cable Properties: The Sink

    V. Excitation and Active Cellular Properties: The Source

    VI. Propagation of the Action Potential

    VII. Automaticity

    VIII. Electrophysiologic Matrix and Cardiac Excitability Revisited



Product details

  • No. of pages: 564
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: June 28, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9780323145961

About the Editor

Oscar Garfein

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