Current Biochemical Research in China

Current Biochemical Research in China

1st Edition - January 28, 1989

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  • Editor: C Tsou
  • eBook ISBN: 9780323157872

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Current Biochemical Research in China presents the Chinese contributions to the biochemical sciences. This book aims to make the situation of biochemical research in China better known to the rest of the world. Organized into 21 chapters, this book begins with an overview of some of the fundamental research of Chinese biochemists, which may be found interesting by colleagues in the western world. This text then presents the investigations of the relationship between structure and function of proteins by synthetic methods. Other chapters provide the comprehensive and scientific compilation of the herb medicines used in China since ancient times. This book discusses as well the correlation of molecular structures of proteins with their biological functions. The final chapter deals with the importance of hemostasis and thrombosis wherein platelets adhere to injured vascular wall and aggregate to form the white hemostatic plug. This book is a valuable resource for biochemists, biophysicists, scientists, and research workers.

Table of Contents

  • Contributors


    1. Development of Biochemical Research in China

    I. Introduction

    II. General Situation, 1949-1966

    III. Research Activities, 1949-1966

    IV. 1966 and after


    2. Chemical Synthesis and Structure-Function Studies of Bioactive Peptides

    I. Improvements in Peptide Synthesis

    II. Structure-Function Studies


    3. Trichosanthin: From Chinese Herb Medicine to Ribosome Inactivating Protein

    I. Introduction

    II. Structure Investigation

    III. Relationship of Structure and Function

    IV. Prospects


    4. Structure, Function, and Evolution of Certain Proteins

    I. Introduction

    II. Active Products of Porcine Trypsin after Autolysis

    III. Comparative Study of Primary Structures of Lactate Dehydrogenase Isozymes M4 from Giant Panda and Other Related Mammals

    IV. Perspective


    5. Kinetics of Substrate Reaction during Modification of Enzyme Activity: Theory and Applications

    I. Introduction

    II. Kinetics of Substrate Reactions during Enzyme Modification

    III. Experimental Studies

    IV. Discussion


    6. Mechanism of Snake Muscle Fructose 1,6-Bisphosphatase

    I. Introduction

    II. Phosphorylated Intermediate of Fructose 1,6-Bisphosphatase

    III. Kinetics

    IV. Regulation of Snake Muscle Fructose 1,6-Bisphosphatase


    7. Urokinase and Its Related Proteases in Human Urine

    I. Introduction

    II. Benzamidine-Zinc Biaffinity Chromatography of Multiple Forms of Urokinase

    III. Identification and Properties of Different Molecular Forms of Urokinase

    IV. Prediction of Conformation of the Two Urokinase Fragments Involved in Inhibitor Binding


    8. The Precise Structure of Insulin and Despentapeptide Insulin at High Resolution

    I. Introduction

    II. The Precise Structure of Insulin

    III. Structure of Despentapeptide (B26-30) Insulin

    IV. What Have We Learned from the Studies of Structure at High Resolution?


    9. Correct Pairing of Insulin A and Β Chains in Solution and the Formation of the Native from the Scrambled Hormone

    I. Introduction

    II. Interaction of the Chains

    III. Formation of Native Insulin by Protein Disulfide Isomerase

    IV. Discussion


    10. Modern Aspects of Insulin and C Peptide Synthesis

    I. Introduction

    II. Insulin A and Β Chains

    III. Proinsulin C Peptide


    11. Structure-Function Studies of Insulin

    I. Semisynthetic Analogs

    II. Analogs Prepared by Enzymatic Synthesis

    III. Insulins from Different Species

    IV. Analogs through Site-Directed Mutagenesis


    12. Coupling Problems of Photophosphorylation

    I. Coupling Mechanism of Photophosphorylation

    II. The Stoichiometry between Phosphorylation and Electron Transport

    III. The Degree of Coupling in Vivo and Its Regulation


    13. Study on the Lipid-Protein Interactions in Η+-ATPase of Mitochondria

    I. Lipid Structure Related to the Reactivation of Phospholipid-Deficient Η+ - ATPase

    II. Mg2+-Mediated Change in the Physical State of Phospholipid Modulates Η+-ATPase Activity


    14. A New Function of Proton Pumps in Membrane Fusion

    I. Introduction

    II. Proton Pumping Induces Membrane Fusion between Liposomes and Native Membranes Bearing Proton-Pumping Systems

    III. Proton Pumping Induces Membrane Fusion of Reconstituted Cytochrome C Oxidase Phospholipid Vesicles with Liposomes

    IV. Is Proton Pumping Induced Membrane Fusion an Energy-Dependent or H+-Consuming Process?

    V. A New Hypothetical Model for Proton Pumping Induced Membrane Fusion


    15. The Interaction of Anisodamine with Biological Membranes

    I. Introduction

    II. The Interaction of Anisodamine with Model Membranes

    III. The Interaction of Anisodamine with Biological Membranes

    IV. Effect of Anisodamine on the Phase Behavior of Phospholipid Liposomes

    V. The Possible Mechanism of Action of Anisodamine on Biological Membranes

    VI. Conclusions


    16. Thirty Years of Study of Ribonucleic Acids

    I. Work on tRNA before 1966

    II. Total Synthesis of Yeast tRNAAla

    III. Structure and Function Relationships of Yeast tRNAAla

    IV. Other tRNA Research

    V. RNA Sequencing

    VI. 5 S rRNA Structure

    VII. Molecular Evolution of Eukaryotic 5 S rRNAs

    VIII. Biologically Active Oligonucleotides and Others

    IX. Concluding Remarks


    17. Cloning and Expression of Hepatitis B Virus Genes

    I. Introduction

    II. Cloning and Restriction Mapping of HBV Genomic DNA

    III. Sequence Analysis of Cloned HBV Genomic DNA Subtype adr

    IV. The Expression of the HBsAg Genes

    V. Vaccinia Virus Vector System

    VI. Expression of HBsAg with PreS—The Possible HBV Vaccine of a New Generation

    VII. The Expression of the HBcAg Gene

    VIII. Concluding Remarks


    18. The Mechanism of the Replication of Cytoplasmic Polyhedrosis Virus of the Silkworm Bombyx mori

    I. Introduction

    II. Preparation of Cytoplasmic Polyhedrosis Virus

    III. Relationship between the RNA Polymerase Activity and Infectivity

    IV. Location and Replication of RNA Polymerase

    V. Isolation and Reconstitution of RNA Polymerase and Methyltransferase

    VI. Transcription and Translation in Vitro

    VII. Conclusion


    19. Molecular Aspects of Heat Shock Response in Human T Lymphocytes

    I. The Heat Shock Response—A Mystery of Living Organisms

    II. The Expression of HSP Genes in T Lymphocytes

    III. The Effect of Heat Shock on T-Lymphocyte Activation

    IV. The Transcription of Cellular Genes in Heat-Shocked T Lymphocytes


    20. Phenotypes of Alpha-1-Proteinase Inhibitor and Their Racial Specificity and Geographical Variability in Mainland China

    I. Introduction

    II. Phenotypes and Allelic Frequencies of PI in Normal Chinese Populations

    III. Is Variant Etokyo Pathogenic?

    IV. The Genetic Types of Alpha-1-Proteinase Inhibitor in Chinese Patients with Pulmonary Emphysema


    21. Studies of Platelet Membrane Glycoproteins Using Monoclonal Antibodies

    I. Glycoprotein Ib-IX Complex and Platelet Adhesion

    II. Glycoprotein IIb-IIIa Complex and Platelet Aggregation

    III. Approach to Clinical Application



Product details

  • No. of pages: 282
  • Language: English
  • Copyright: © Academic Press 1989
  • Published: January 28, 1989
  • Imprint: Academic Press
  • eBook ISBN: 9780323157872

About the Editor

C Tsou

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