Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice

Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice

8th Edition - August 7, 2018

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  • Authors: Charles Lockwood, Thomas Moore, Joshua Copel, Robert Silver, Robert Resnik
  • eBook ISBN: 9780323568913

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Description

Long recognized as the authoritative leader in the field, Creasy and Resnik's Maternal-Fetal Medicine, 8th Edition, continues to provide the latest evidence-based guidelines for obstetric and neonatal management, helping you minimize complications and offer patients the best possible care. Written by renowned experts in obstetrics, gynecology, and perinatology, this comprehensive resource has been thoroughly updated and reflects new information in every area, including recent tremendous advances in genetics, imaging, and more.

Table of Contents

  • Cover image
  • Title Page
  • Table of Contents
  • Copyright
  • Dedication
  • Contributors
  • Preface
  • Part 1 Scientific Basis of Perinatal Biology
  • 1 Human Genetics and Patterns of Inheritance
  • DNA Structure
  • Cell Division
  • Errors in Meiosis
  • Errors in Mitosis
  • Mendelian Inheritance
  • Mitochondrial Inheritance
  • Trinucleotide Repeats
  • Key Points
  • References
  • 2 Molecular Genetic Technology
  • Detecting the Genetic Basis of Disease
  • Sources of Parental Genetic Material
  • Sources of Fetal Genetic Material
  • Cytogenetic Testing: Detection of Chromosomal or Subchromosomal Abnormalities
  • Genotyping/Sequencing
  • Special Applications
  • Conclusion
  • Key Points
  • References
  • 3 Normal Early Development
  • Preimplantation Development
  • Implantation
  • Postimplantation Placental Development
  • Imprinting and Placental Development
  • Embryonic Development: From the Primitive Streak Through Gastrulation
  • Early Embryonic Development Postgastrulation
  • Organogenesis
  • Conclusion
  • Key Points
  • References
  • 4 Amniotic Fluid Dynamics
  • Volume of Amniotic Fluid
  • Production and Composition of Amniotic Fluid
  • Resorption of Amniotic Fluid
  • Possible Mechanisms to Regulate Amniotic Fluid Volume via Intramembranous Flow
  • Possible Regulation of Intramembranous Flow
  • Key Points
  • References
  • 5 Multiple Gestation
  • Zygosity and Chorionicity
  • Mechanisms Underlying Dizygotic and Monozygotic Twinning
  • Twin Placentation Types
  • Complications of Monochorionic Twinning and Their Associated Placental Characteristics
  • Complications of Dichorionic Twinning
  • Key Points
  • References
  • 6 Physiology of Parturition
  • Morphologic Changes in the Reproductive Tract During Pregnancy
  • Diagnosis of Labor
  • Timing of Labor
  • Genetic Influences on the Timing of Labor
  • Hormonal Control of Labor
  • Myometrial Contractility
  • Role of the Cervix in Labor
  • Abnormal Timing of Labor
  • Achieving a Successful Vaginal Delivery
  • Conclusions
  • Key Points
  • References
  • 7 Pathogenesis of Spontaneous Preterm Birth
  • Preterm Birth Syndrome: Phenotypic Classification
  • Mechanisms of Spontaneous Preterm Birth
  • Phenotypic Components of the Preterm Birth Syndrome
  • Key Points
  • References
  • 8 Immunology of Pregnancy
  • Pregnancy as an Allograft
  • Defining the Immunology of Pregnancy
  • General Concepts of Immunology
  • Maternal Immune Responses to the Trophoblast: The Pregnant Uterus as an Immune Privileged Site
  • Role of Immune Cells During Pregnancy
  • Infection and Pregnancy
  • How a Viral Infection Affects the Fetus and Pregnancy Outcome
  • Mother-Placenta-Fetus: A Complex Response to Infection
  • Are Prophylaxis and Treatment Appropriate and Beneficial for Pregnant Women?
  • Key Points
  • References
  • 9 Maternal Cardiovascular, Respiratory, and Renal Adaptation to Pregnancy
  • Cardiovascular System
  • Respiratory System
  • Kidneys and Lower Urinary Tract
  • Key Points
  • References
  • 10 Endocrinology of Pregnancy
  • Implantation
  • Concept of Immunotolerance in the Uterus
  • Human Chorionic Gonadotropin Production
  • Maintenance of Early Pregnancy: Human Chorionic Gonadotropin and Corpus Luteum of Pregnancy
  • Timing of the Luteal-Placental Shift
  • Fetoplacental Unit as an Endocrine Organ
  • Pregnancy-Specific Glycoproteins
  • Endocrine-Metabolic Changes in Pregnancy
  • Key Points
  • References
  • 11 The Breast and the Physiology of Lactation
  • Benefits of Breastfeeding
  • The Breast
  • Physiology of Lactation
  • Initiating Breastfeeding
  • Issues in the Postpartum Period
  • Contraception
  • Maternal Infections During Breastfeeding
  • Complications of the Breast
  • Ongoing Breastfeeding Support
  • Medications While Breastfeeding
  • Key Points
  • Suggested Readings
  • References
  • 12 Maternal Nutrition
  • What Is Healthy Eating During Pregnancy?
  • Foods to Avoid or Limit During Pregnancy
  • Weight Gain During Pregnancy
  • Interventions to Optimize Gestational Weight Gain
  • Considerations for Special Populations
  • Key Points
  • References
  • 13 Fetal Cardiovascular Physiology
  • Blood Flow Patterns and Oxygen Delivery
  • Control of the Cardiovascular System
  • Ductus Arteriosus
  • Key Points
  • References
  • 14 Behavioral States in the Fetus
  • Fetal Behavioral State Activity
  • Developmental Changes
  • Assessment of Fetal Health
  • Fetal Growth and Development
  • Key Points
  • References
  • 15 Placental Respiratory Gas Exchange and Fetal Oxygenation
  • Transport of Atmospheric Oxygen to Fetal Tissues
  • Measurement of Uterine and Umbilical Oxygen Uptakes
  • Umbilical Oxygen Uptake
  • Normal Fetal Oxygenation
  • Fetal Response to Acute Hypoxia
  • Oxygen Therapy
  • Placental Carbon Dioxide Transfer
  • Acknowledgments
  • Key Points
  • References
  • 16 Fetal Lung Development and Surfactant
  • Overview of Lung Development
  • Normal Lung Development
  • Pulmonary Hypoplasia
  • Fetal Lung Fluid
  • Surfactant
  • Induced Lung Maturation and Pulmonary Outcomes
  • Overview of Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, and Mediators
  • Key Points
  • References
  • 17 Evidence-Based Practice in Perinatal Medicine
  • Evidence-Based Medicine in Perspective
  • Types of Clinical Research Studies
  • Types of Data for Clinical Research
  • Error in Clinical Research
  • Assessing Research on Screening and Diagnosis
  • Other Prediction Analysis
  • Summary
  • Key Points
  • References
  • Part 2 Obstetric Imaging
  • Section I Principles of Fetal Imaging
  • 18 Performing and Documenting the Fetal Anatomy Ultrasound Examination
  • Categorizing Types of Obstetric Ultrasound Examinations
  • The Basic Midtrimester Fetal Anatomy Scan (CPT 76805)
  • Documentation of the Obstetric Ultrasound Examination
  • The Detailed Maternal and Fetal Evaluation Study (CPT 76811)
  • Typical Images Obtained in a CPT 76811 Detailed Obstetric Ultrasound Examination
  • Key Points
  • References
  • 19 Doppler Ultrasound
  • Umbilical Artery
  • Middle Cerebral Artery
  • Ductus Venosus
  • Uterine Artery
  • Key Points
  • References
  • 20 Clinical Applications of Three-Dimensional Sonography in Obstetrics
  • Basics of Volume Sonography
  • Imaging Tools in Volume Sonography
  • Use of Three-Dimensional Ultrasonography in First Trimester
  • Use of Three-Dimensional Ultrasound in Second Trimester
  • Parental Bonding and Fetal Behavior
  • Medicolegal Issues
  • Future of Volume Sonography in Obstetrics
  • Key Points
  • References
  • 21 Role of Magnetic Resonance Imaging in Obstetric Imaging
  • Safety
  • Examination Technique and Fundamentals
  • Brain
  • Body Anomalies
  • Complications of Twinning
  • Tumors
  • Conclusion
  • Key Points
  • References
  • Section II Lesions
  • 22 Central Nervous System Imaging
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • 23 Imaging of the Face and Neck
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • References
  • 24 Thoracic Imaging
  • Diagnosis
  • Imaging
  • Management
  • Key Points
  • References
  • Diagnosis
  • Imaging
  • Management
  • Key Points
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • 25 Fetal Cardiac Malformations and Arrhythmias
  • Incidence of Congenital Heart Disease in the Fetus
  • Risk Factors for Congenital Heart Disease in the Fetus
  • Screening for Congenital Heart Disease in the Fetus
  • Technique of Fetal Echocardiography
  • Fetal Cardiac Malformations: Diagnosis, Management, and Prognosis
  • Fetal Arrhythmias: Diagnosis, Management, and Prognosis
  • Conclusions
  • Key Points
  • References
  • 26 Abdominal Imaging
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • 27 Urogenital Imaging
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence/Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • 28 Skeletal Imaging
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology and Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • Definition
  • Incidence and Epidemiology
  • Etiology/Pathogenesis
  • Diagnostic Features
  • Differential Diagnosis
  • Associated Anomalies
  • Prognosis
  • Antenatal Management
  • Neonatal Management
  • Key Points
  • References
  • 29 Placenta and Umbilical Cord Imaging
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • 30 Uterus and Adnexae Imaging
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • Diagnosis
  • Imaging
  • Management
  • Suggested Readings
  • 31 First-Trimester Imaging
  • Diagnosis
  • Imaging
  • Management
  • Key Point
  • References
  • Imaging
  • Management
  • Key Points
  • References
  • Diagnosis
  • Imaging
  • Management
  • References
  • Part 3 Fetal Disorders: Diagnosis and Therapy
  • 32 Prenatal Diagnosis of Congenital Disorders
  • Screening for Fetal Genetic Disorders
  • Abnormal Screening Markers in Pregnancies With a Normal Karyotype
  • Maternal Serum Alpha Fetoprotein Screening for Neural Tube Defects and Other Structural Defects
  • Screening for Gene Mutations That Lead to Fetal Disease
  • Diagnostic Tests
  • Key Points
  • References
  • 33 Teratogenesis and Environmental Exposure
  • Historical Perspective
  • Principles of Teratology
  • Sources of Data on Safety and Risks of Exposures in Pregnancy
  • Risk Assessments and Resources
  • Selected Human Teratogenic Exposures
  • Acknowledgment
  • Key Points
  • References
  • 34 Assessment of Fetal Health
  • Principles of Ideal Fetal Monitoring
  • Assessment of Normal Fetal Physiology
  • Methods of Monitoring Fetal Health
  • Practical Aspects of Fetal Testing
  • Summary
  • Acknowledgment
  • Key Points
  • References
  • 35 Intrapartum Fetal Surveillance
  • Factors Controlling Fetal Heart Rate
  • Monitoring Fetal Heart Rate
  • Fetal Responses to Hypoxia or Acidemia
  • Fetal Acid-Base Balance
  • Characteristics of Fetal Heart Rate Patterns
  • Efficacy, Risks, and Recommendations for Monitoring
  • Key Points
  • Acknowledgments
  • References
  • 36 Assessment and Induction of Fetal Pulmonary Maturity
  • Assessment of Fetal Pulmonary Maturity
  • Induction of Fetal Pulmonary Maturity
  • Summary
  • Key Points
  • References
  • 37 Invasive Fetal Therapy
  • Open Fetal Surgery
  • Complicated Monochorionic Twin Pregnancies
  • Twin-Twin Transfusion Syndrome
  • Selective Feticide for Other Complications
  • Isolated Congenital Diaphragmatic Hernia
  • Congenital Thoracic Malformations
  • Lower Urinary Tract Obstruction
  • Congenital Heart Defects
  • Myelomeningocele Repair
  • Sacrococcygeal Teratoma
  • Chorioangioma
  • Key Points
  • Acknowledgment
  • References
  • 38 Hemolytic Disease of the Fetus and Newborn
  • History
  • Red Cell Alloimmunization
  • Hemolytic Disease of the Fetus and Newborn Caused by Non-RhD Antibodies
  • Future Therapy
  • Key Points
  • References
  • 39 Nonimmune Hydrops
  • Diagnosis
  • Etiology
  • Experimental Management of Idiopathic Cases
  • Diagnostic Approach to the Fetus With Hydrops
  • Management
  • Prevention
  • Summary
  • Key Points
  • References
  • 40 Multiple Gestation
  • Perinatal Mortality and Morbidity
  • Maternal Mortality and Morbidity
  • Maternal Adaptations
  • Ultrasonography in Multiple Gestation
  • Prenatal Diagnosis
  • Antepartum Management
  • Intrapartum Management
  • Special Considerations in Management
  • Key Points
  • References
  • Part 4 Disorders at the Maternal-Fetal Interface
  • 41 Prevention and Management of Preterm Parturition
  • The Problem of Preterm Birth
  • Clinical Presentations of Preterm Birth
  • Consequences of Preterm Birth
  • Epidemiology and Risk Factors for Preterm Birth
  • Interventional Strategies for Preterm Labor
  • Prevention of Preterm Birth
  • References
  • 42 Premature Rupture of the Membranes
  • Physiology and Pathophysiology of Membrane Rupture
  • Prediction and Prevention
  • Epidemiology and Clinical Course
  • Complications After Premature Rupture of the Membranes
  • Diagnosis
  • Management of Premature Rupture of the Membranes
  • Key Points
  • References
  • 43 Clinical Aspects of Normal and Abnormal Labor
  • Normal Labor and Its Limits
  • Categorization of Labor Events
  • Characteristics of the Maternal Pelvis
  • Role of Maternal Obesity
  • Documentation of Labor Progression
  • Management of Labor Abnormalities
  • Induction of Labor
  • Abnormal Presentation
  • Operative Delivery
  • Analgesia and Anesthesia for Low-Risk Labor and Vaginal Delivery
  • Labor Monitoring
  • Acknowledgment
  • Key Points
  • References
  • 44 Recurrent Pregnancy Loss
  • Definitions
  • Genetic Factors
  • Uterine Factors
  • Hematologic Factors
  • Coagulopathy
  • Environment
  • Endocrine Factors
  • Male Factors
  • Immunologic Factors
  • Diagnosing and Managing Pregnancy Loss
  • Future Direction
  • References
  • 45 Stillbirth
  • Epidemiology
  • Risk Factors for Stillbirth
  • Classification of Stillbirth
  • Pathogenesis (Causes of Stillbirth)
  • Diagnosis and Evaluation
  • Management
  • Prediction of Stillbirth
  • Prevention of Stillbirth
  • Management of Subsequent Pregnancy
  • Key Points
  • References
  • 46 Placenta Previa and Accreta, Vasa Previa, Subchorionic Hemorrhage, and Abruptio Placentae
  • Placenta Previa
  • Vasa Previa
  • Subchorionic Hemorrhage
  • Abruptio Placentae
  • Key Points
  • References
  • 47 Intrauterine Growth Restriction
  • Definitions
  • Rate of Fetal Growth
  • Classification of Fetal Growth Restriction
  • Incidence of Fetal Growth Restriction
  • Perinatal Mortality and Morbidity
  • Etiology of Fetal Growth Restriction
  • Structural Abnormalities
  • Diagnosis of Fetal Growth Restriction
  • First-Trimester Serum Analytes
  • Management of Pregnancy
  • Neonatal Complications and Long-Term Sequelae
  • Key Points
  • Acknowledgment
  • References
  • 48 Pregnancy-Related Hypertension
  • Classification of Hypertensive Disorders
  • Preeclampsia-Eclampsia
  • Chronic Hypertension
  • Acknowledgments
  • Key Points
  • References
  • Part 5 Maternal Complications
  • 49 Patient Safety and Quality Improvement in Obstetrics
  • The Patient Safety Movement
  • Safety Challenges in Obstetrics
  • Potential Strategies to Improve Patient Safety
  • Evaluation of Progress: Outcomes and Measures
  • Economics of Patient Safety
  • Coping With the Aftermath of Adverse Events
  • Key Points
  • References
  • 50 Maternal Mortality
  • Measurement/Definitions
  • Epidemiology
  • Demographics
  • Role of State Maternal Mortality Review Committees
  • Causes and Preventability of Maternal Mortality
  • “Near Miss” or Severe Maternal Morbidity
  • Role of Obstetrics Leaders in Reducing Maternal Mortality
  • Key Points
  • Acknowledgment
  • References
  • 51 Maternal and Fetal Infections
  • Genital Infections
  • Urinary Tract Infections
  • Chorioamnionitis
  • Episiotomy Infections
  • Puerperal Endometritis
  • Wound Infection
  • Pelvic Abscess
  • Sepsis Syndrome and Septic Shock
  • Septic Pelvic Vein Thrombophlebitis
  • Mastitis
  • Cytomegalovirus Infection
  • Group B Streptococcal Infection
  • Herpes Simplex Virus Infection
  • Human Immunodeficiency Virus Infection
  • Listeriosis
  • Mumps
  • Parvovirus Infection
  • Rubella
  • Rubeola
  • Syphilis
  • Toxoplasmosis
  • Varicella-Zoster Virus Infection
  • Viral Influenza
  • Viral Hepatitis
  • Ebola Virus Disease
  • Zika Virus Infection
  • References
  • 52 Cardiac Diseases
  • Diagnosis of Heart Disease in Pregnancy
  • Preconception Counseling
  • Cardiovascular Adaptations to Pregnancy
  • General Guidelines for Management
  • Congenital Heart Disease
  • Congenital Obstructive Lesions
  • Other Congenital Cardiac Malformations
  • Rheumatic Heart Disease
  • Mitral Valve Prolapse
  • Aortic Valve Disease
  • Drug-Induced Valvular Heart Disease
  • Cardiomyopathy
  • Coronary Artery Disease
  • Heart Failure
  • Disturbances of Cardiac Rhythm
  • Marfan Syndrome
  • Pregnancy in Patients With Artificial Heart Valves
  • Cardiac Surgery During Pregnancy
  • Use of Prophylactic Antibiotics to Prevent Infective Endocarditis in Pregnant Women With Heart Disease
  • Cardiovascular Sequelae of Kawasaki Disease
  • Key Points
  • References
  • 53 Coagulation Disorders in Pregnancy
  • Hemostatic System
  • Disorders Promoting Thrombosis in Pregnancy
  • Bleeding Disorders
  • References
  • 54 Thromboembolic Disease in Pregnancy
  • Risk Factors
  • Diagnosis and Evaluation of Venous Thromboembolism in Pregnancy
  • Acute Pulmonary Embolism
  • Treatment of Venous Thromboembolism in Pregnancy
  • Prevention of Venous Thromboembolism in Pregnancy
  • Summary
  • References
  • 55 Anemia and Pregnancy
  • Clinical Presentation
  • Evaluation of Anemia
  • Normal Hematologic Events Associated With Pregnancy
  • Morphologic Classification of Anemia
  • Effects of Maternal Anemia on the Fetus
  • Specific Anemias
  • Hemoglobinopathies
  • Anemias Associated With Systemic Disease
  • Key Points
  • References
  • 56 Malignancy and Pregnancy
  • Epidemiologic Overview of Cancer in Pregnancy
  • Ovarian and Cervical Malignancies
  • Treatment of Cancer During Pregnancy
  • Gestational Trophoblastic Disease
  • Genetic Syndromes Associated With Gynecologic Malignancies
  • Pregnancy and Solid Tumors
  • Hematologic Malignancies During Pregnancy
  • Key Points
  • References
  • 57 Renal Disorders
  • Urinary Tract Infection
  • Acute Renal Failure in Pregnancy
  • Chronic Kidney Disease and Pregnancy
  • Problems Associated With Specific Diseases of the Kidney
  • Dialysis Patients and Pregnancy
  • Renal Transplant and Pregnancy
  • Acknowledgments
  • Key Points
  • References
  • 58 Respiratory Diseases in Pregnancy
  • Physiologic Changes of the Respiratory System
  • Anatomic Changes of the Respiratory System
  • Oxygen Delivery and Consumption
  • Pneumonia in Pregnancy
  • Tuberculosis in Pregnancy
  • Asthma in Pregnancy
  • Restrictive Lung Disease in Pregnancy
  • Cystic Fibrosis in Pregnancy
  • Key Points
  • References
  • 59 Diabetes in Pregnancy
  • Global Prevalence of Diabetes
  • Classification of Diabetes Mellitus
  • Maternal-Fetal Metabolism in Normal and Diabetic Pregnancy
  • Complications of Diabetes During Pregnancy
  • Management
  • Pregnancy Management in the Diabetic Patient and Fetus
  • Management of the Neonate
  • Key Points
  • References
  • 60 Obesity in Pregnancy
  • Epidemiology
  • Anthropometric Measures in Pregnancy
  • Pathophysiologic Effects of Maternal Obesity
  • Weight Management in Pregnancy
  • Managing Risks During Pregnancy
  • Intrapartum Management
  • Venous Thromboembolism and Postoperative Thromboprophylaxis
  • Bariatric Surgery
  • Stigma and the Environment
  • Patient Management Across Pregnancy
  • Key Points
  • References
  • 61 Thyroid Disease and Pregnancy
  • Maternal-Fetal Thyroid Physiology
  • Placental-Fetal Thyroid Physiology
  • Pregnancy, the Immune System, and Thyroid Disease
  • Laboratory Evaluation of Thyroid Function During Pregnancy
  • Thyroid Dysfunction and Reproductive Disorders
  • Hyperthyroidism
  • Iodine Deficiency, Thyroid Dysfunction, and Mental Retardation
  • Hypothyroidism
  • Thyroid Nodules, Malignant Tumors, and Nontoxic Goiter in Pregnancy
  • Postpartum Thyroid Disease
  • Key Points
  • References
  • 62 Other Endocrine Disorders of Pregnancy
  • Hypothalamus and Pituitary
  • Adrenal Glands
  • Hirsutism and Virilization in Pregnancy
  • Parathyroid Glands and Calcium Metabolism
  • Key Points
  • References
  • 63 Gastrointestinal Disease in Pregnancy
  • Alterations in Normal Gastrointestinal Function in Pregnancy
  • Nausea and Vomiting
  • Hyperemesis Gravidarum
  • Gastroesophageal Reflux Disease
  • Peptic Ulcer Disease
  • Appendicitis
  • Inflammatory Bowel Disease
  • Irritable Bowel Syndrome
  • Celiac Disease
  • Constipation
  • Hemorrhoids
  • Gastrointestinal Endoscopy in Pregnancy
  • Summary and Recommendations
  • Key Points
  • References
  • 64 Diseases of the Liver, Biliary System, and Pancreas
  • Liver Function in Normal Pregnancy
  • Clinical Diagnosis of Liver Disease
  • Liver Disorders Unique to Pregnancy
  • Maternal Disorders Coincidental to Pregnancy
  • Chronic Liver Disease in Pregnancy
  • Acute Liver Failure During Pregnancy
  • Liver Transplantation and Pregnancy
  • Nonalcoholic Fatty Liver Disease
  • Gallbladder Disease
  • Pancreatitis
  • Key Points
  • Acknowledgment
  • References
  • 65 Pregnancy and Rheumatic Diseases
  • Systemic Lupus Erythematosus
  • Antiphospholipid Syndrome
  • Rheumatoid Arthritis
  • Sjögren Syndrome
  • Systemic Sclerosis
  • Systemic Vasculitis
  • Key Points
  • References
  • 66 Neurologic Disorders
  • Epilepsy
  • Key Points
  • Headache
  • Key Points
  • Tumors
  • Pseudotumor Cerebri
  • Occlusive Cerebrovascular Disease
  • Key Points
  • Intracranial Hemorrhage
  • Vascular Anomalies and the Nervous System
  • Infections
  • Poliomyelitis
  • Metabolic Disorders
  • Movement Disorders
  • Optic Neuritis
  • Traumatic Paraplegia
  • Root Lesions
  • Plexus Lesions and Peripheral Mononeuropathies
  • Key Points
  • Polyneuropathies
  • Myasthenia Gravis
  • Key Points
  • Disorders of Muscle
  • Psychiatric Disorders
  • References
  • 67 Management of Depression and Psychoses in Pregnancy and in the Puerperium
  • Epidemiology
  • Pathogenesis of Mood Disorders and Psychotic Disorders, and the Effects of Pregnancy and Delivery
  • Diagnosis of Mood or Psychotic Disorders
  • Management
  • Risks of Psychopharmacologic Treatment During Pregnancy
  • Clinical Approach to Treatment of Depression and Psychoses in Pregnancy
  • Peripartum Complications
  • Postpartum Prevention
  • Summary
  • Key Points
  • References
  • 68 Substance Abuse in Pregnancy
  • Extent of Drug Abuse and Dependence in the United States
  • Screening of Pregnant Patients
  • Tobacco
  • Alcohol
  • Marijuana
  • Opioids
  • Cocaine
  • Methamphetamine
  • Benzodiazepines
  • Conclusions
  • Key Points
  • References
  • 69 The Skin and Pregnancy
  • Common Skin Changes Induced by Pregnancy
  • Skin Conditions Specific to Pregnancy
  • Skin Disorders Affected by Pregnancy
  • Key Points
  • References
  • 70 Anesthesia Considerations for Complicated Pregnancies
  • Maternal Morbidity and Mortality Trends
  • Improving Patient Safety
  • Management of Individual Conditions
  • Sepsis
  • Substance Abuse
  • Trauma Management in Pregnancy
  • Key Points
  • References
  • 71 Intensive Care Considerations for the Critically Ill Parturient
  • Guidelines for Intensive Care Unit Admission and Triage
  • Epidemiology of Critical Care in Obstetrics
  • Tools, Techniques, and Competencies in Critical Care
  • Monitoring
  • Critical Care Syndromes
  • Role of the Obstetrician or Maternal-Fetal Medicine Physician in the Intensive Care Unit
  • After Discharge From the Intensive Care Unit
  • Key Points
  • References
  • 72 Pregnancy as a Window to Future Health
  • Accumulation of Cardiovascular Disease Risk Across the Life Course
  • Hypertension
  • Hypertensive Disorders of Pregnancy
  • Gestational Diabetes Mellitus
  • Preterm Birth
  • Fetal Growth Abnormalities
  • Parity, First Birth, and Last Birth
  • How to Leverage Pregnancy to Improve the Health of Women and Infants
  • Adapting Recommendations for Detection of Risk
  • Prevention in Premenopausal and Postmenopausal Women
  • Diagnosis and Treatment in Women With Prior Adverse Pregnancy Outcomes
  • Next Steps
  • Key Points
  • References
  • Part 6 The Neonate
  • 73 Neonatal Morbidities of Prenatal and Perinatal Origin
  • Obstetric Decisions and Neonatal Outcomes
  • Prematurity
  • Prenatal and Perinatal Morbidities
  • Key Points
  • References
  • Index

Product details

  • No. of pages: 1408
  • Language: English
  • Copyright: © Elsevier 2018
  • Published: August 7, 2018
  • Imprint: Elsevier
  • eBook ISBN: 9780323568913

About the Authors

Charles Lockwood

Affiliations and Expertise

Dean, College of Medicine, Professor of Obstetrics and Gynecology, Leslie H. and Abigail S. Wexner Dean's Chair in Medicine, Vice President for Health Science, The Ohio State University, Columbus, Ohio

Thomas Moore

Affiliations and Expertise

Professor and Chairman, Department of Reproductive Medicine, University of California San Diego School of Medicine, La Jolla, CA

Joshua Copel

Affiliations and Expertise

Professor and Vice Chair, Obstetrics, Obstetrics, Gynecology, and Reproductive Sciences, Professor, Pediatrics, Yale University School of Medicine, New Haven, CT

Robert Silver

Robert Resnik

Affiliations and Expertise

Professor and Chair Emeritus, Department of Reproductive Medicine, University of California San Diego School of Medicine, La Jolla, CA

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