1 Evidence-based medicine
What is evidence-based medicine?
Formulating clinical questions
Identifying relevant evidence
Critically appraising the evidence
Assessing the results
Implementing the results
Creating guideline recommendations
2 Handling data
Types of variables
Displaying the distribution of a single variable
Displaying the distribution of two variables
Describing the frequency distribution: central tendency
Describing the frequency distribution: variability
Choosing the correct summary measure
3 Investigating hypotheses
Choosing a sample
Extrapolating from ‘sample’ to ‘population’
Comparing means and proportions: confidence intervals
Statistical significance and clinical significance
4 Systematic review and meta-analysis
Why do we need systematic reviews?
Advantages and disadvantages
Key example of a meta-analysis
Reporting a systematic review
5 Research design
Bradford-Hill criteria for causality
Choosing the right study design
Writing up a research study
6 Randomised controlled trials
Why choose an interventional study design?
Parallel randomised controlled trials
Confounding, causality and bias
Interpreting the results
Types of randomised controlled trials
Advantages and disadvantag
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- Mosby Ltd.
- eBook ISBN:
Core Medical Trainee, King's College Hospital, London, UK