Crash Course Evidence-Based Medicine: Reading and Writing Medical Papers - 1st Edition

Crash Course Evidence-Based Medicine: Reading and Writing Medical Papers

1st Edition

Authors: Amit Kaura
Imprint: Mosby Ltd.

Table of Contents

1 Evidence-based medicine

What is evidence-based medicine?

Formulating clinical questions

Identifying relevant evidence

Critically appraising the evidence

Assessing the results

Implementing the results

Evaluating performance

Creating guideline recommendations

2 Handling data

Types of variables

Displaying the distribution of a single variable

Displaying the distribution of two variables

Describing the frequency distribution: central tendency

Describing the frequency distribution: variability

Theoretical distributions


Choosing the correct summary measure

3 Investigating hypotheses

Hypothesis testing

Choosing a sample

Extrapolating from ‘sample’ to ‘population’

Comparing means and proportions: confidence intervals

The P-value

Statistical significance and clinical significance

Statistical power

4 Systematic review and meta-analysis

Why do we need systematic reviews?

Evidence synthesis


Presenting meta-analyses

Evaluating meta-analyses

Advantages and disadvantages

Key example of a meta-analysis

Reporting a systematic review

5 Research design

Obtaining data

Interventional studies

Observational studies

Clinical trials

Bradford-Hill criteria for causality

Choosing the right study design

Writing up a research study

6 Randomised controlled trials

Why choose an interventional study design?

Parallel randomised controlled trials

Confounding, causality and bias

Interpreting the results

Types of randomised controlled trials

Advantages and disadvantag


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This essential new addition to the series clearly brings together the related disciplines of evidence-based medicine, statistics, critical appraisal and clinical audit – all so central to current study and to modern clinical practice. It starts with the basics that every student needs to know and continues into sufficient detail to satisfy anyone contemplating their own research studies. Excel in Student Selected Component (SSC) assessments and that dreaded evidence-based medicine and statistics exam! Ensure you know how to prepare the highest quality reports and maximize your chances of getting published.

If you are not sure:

  • why you need to know the standard deviation of a sample
  • when to use a case-control study and when a cohort study
  • what to say to your patient who asks about the benefits and harms of a drug
  • how to argue the case for the inclusion of a drug on the hospital formulary
  • how to make audit and quality improvement work for you,

…then this groundbreaking book is for you! Answer these and hundreds of other questions and lay a foundation for your clinical practice that will inform every consultation over a lifetime in medicine.


Mosby Ltd.
eBook ISBN:

About the Authors

Amit Kaura Author

Affiliations and Expertise

Core Medical Trainee, King's College Hospital, London, UK